Maytansine

immunoglobulin heavy diversity 1-7 ; Homo sapiens







28 Article(s)
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Title
Pub. Year
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1 32495214 The role of autophagy in the cytotoxicity induced by trastuzumab emtansine (T-DM1) in HER2-positive breast cancer cells. 2020 Jun 3 4
2 31416167 Incorporation of a Hydrophilic Spacer Reduces Hepatic Uptake of HER2-Targeting Affibody-DM1 Drug Conjugates. 2019 Aug 14 1
3 31484985 Real-world data on T-DM1 efficacy - results of a single-center retrospective study of HER2-positive breast cancer patients. 2019 Sep 4 1
4 29214842 Trastuzumab emtansine: determining its role in management of HER2+ breast cancer. 2018 Mar 1
5 28377489 Preclinical Activity of the Novel Anti-Prolactin Receptor (PRLR) Antibody-Drug Conjugate REGN2878-DM1 in PRLR-Positive Breast Cancers. 2017 Jul 1
6 28552047 T-DM1 in the Neo-Adjuvant Treatment of HER2-Positive Breast Cancer: Impact of the KRISTINE (TRIO-021) Trial. 2017 2
7 28648785 LC-MS bioanalysis of Trastuzumab and released emtansine using nano-surface and molecular-orientation limited (nSMOL) proteolysis and liquid-liquid partition in plasma of Trastuzumab emtansine-treated breast cancer patients. 2017 Oct 25 1
8 28894364 EpCAM aptamer-functionalized polydopamine-coated mesoporous silica nanoparticles loaded with DM1 for targeted therapy in colorectal cancer. 2017 1
9 25756468 Acute Pancreatitis Associated With Ado-Trastuzumab Emtansine. 2016 Mar-Apr 1
10 26318092 Treatment of HER2 positive advanced breast cancer with T-DM1: A review of the literature. 2016 Jan 3
11 26938945 Trastuzumab-deBouganin Conjugate Overcomes Multiple Mechanisms of T-DM1 Drug Resistance. 2016 Apr 3
12 27274311 Novel approaches to target HER2-positive breast cancer: trastuzumab emtansine. 2016 2
13 25398397 T-DM1, a novel antibody-drug conjugate, is highly effective against uterine and ovarian carcinosarcomas overexpressing HER2. 2015 Jan 1
14 25790739 [Trastuzumab emtansine (Kadcyla(®)) approval in HER2-positive metastatic breast cancers]. 2015 Apr 1
15 25865453 Trastuzumab emtansine in advanced human epidermal growth factor receptor 2-positive breast cancer. 2015 May 2
16 26031461 Non-Clinical Disposition and Metabolism of DM1, a Component of Trastuzumab Emtansine (T-DM1), in Sprague Dawley Rats. 2015 2
17 26240273 Preclinical Efficacy and Safety Assessment of an Antibody-Drug Conjugate Targeting the c-RET Proto-Oncogene for Breast Carcinoma. 2015 Dec 15 1
18 26254411 T-DM1 as a New Treatment Option for Patients with Metastatic HER2-positive Breast Cancer in Clinical Practice. 2015 Sep 1
19 25191794 Site-specific trastuzumab maytansinoid antibody-drug conjugates with improved therapeutic activity through linker and antibody engineering. 2014 Oct 9 1
20 25339854 Enhanced anticancer activity of DM1-loaded star-shaped folate-core PLA-TPGS nanoparticles. 2014 3
21 23402224 Trastuzumab emtansine (T-DM1) for HER2-positive breast cancer. 2013 Apr 3
22 22942906 The potential for trastuzumab emtansine in human epidermal growth factor receptor 2 positive metastatic breast cancer: latest evidence and ongoing studies. 2012 Sep 1
23 23247898 [Antibody-drug conjugates in oncology: from the concept to trastuzumab emtansine (T-DM1)]. 2012 Dec 2
24 24451727 Trastuzumab Emtansine (T-DM1): Hitching a Ride on a Therapeutic Antibody. 2012 1
25 20730488 Trastuzumab-DM1 (T-DM1) retains all the mechanisms of action of trastuzumab and efficiently inhibits growth of lapatinib insensitive breast cancer. 2011 Jul 1
26 21391620 Design of antibody-maytansinoid conjugates allows for efficient detoxification via liver metabolism. 2011 Apr 20 2
27 21481526 Antibody-DM1 conjugates as cancer therapeutics. 2011 Aug 28 1
28 21506905 Trastuzumab emtansine: a novel antibody-drug conjugate for HER2-positive breast cancer. 2011 Jun 2