| 1 |
34564830 | Biological functions and potential therapeutic applications of huntingtin-associated protein 1: progress and prospects. | 2022 Feb |
2 |
| 2 |
35013554 | Extreme conservation of the poly-glutamine tract in huntingtin is related to neurodevelopmental functions: the "better" may become the "enemy of the good" in the course of evolution. | 2022 Feb |
1 |
| 3 |
35046408 | SUPT4H1-edited stem cell therapy rescues neuronal dysfunction in a mouse model for Huntington's disease. | 2022 Jan 19 |
3 |
| 4 |
35051614 | Passive immunization against phosphorylated tau improves features of Huntington's disease pathology. | 2022 Apr 6 |
1 |
| 5 |
35058188 | Time-resolved FRET screening identifies small molecular modifiers of mutant Huntingtin conformational inflexibility in patient-derived cells. | 2022 Jun |
2 |
| 6 |
35108063 | Development of a ligand for in vivo imaging of mutant huntingtin in Huntington's disease. | 2022 Feb 2 |
6 |
| 7 |
35169703 | The long and the short of Huntington's disease: how the sphingolipid profile is shifted in the caudate of advanced clinical cases. | 2022 |
2 |
| 8 |
35200138 | Targeting DNA topoisomerases or checkpoint kinases results in an overload of chaperone systems, triggering aggregation of a metastable subproteome. | 2022 Feb 24 |
1 |
| 9 |
35367225 | Metformin to treat Huntington disease: A pleiotropic drug against a multi-system disorder. | 2022 Jun |
2 |
| 10 |
35395060 | Development of mAb-based polyglutamine-dependent and polyglutamine length-independent huntingtin quantification assays with cross-site validation. | 2022 |
2 |
| 11 |
35427742 | Environmental stimulation in Huntington disease patients and animal models. | 2022 Apr 12 |
1 |
| 12 |
35439000 | Physicochemical Properties Altered by the Tail Group of Lipid Membranes Influence Huntingtin Aggregation and Lipid Binding. | 2022 Apr 28 |
4 |
| 13 |
35444517 | Polyglutamine Expansion in Huntingtin and Mechanism of DNA Damage Repair Defects in Huntington's Disease. | 2022 |
5 |
| 14 |
35447076 | Group dynamics goes awry: PolyQ-expanded huntingtin gains unwanted partners. | 2022 Apr 20 |
3 |
| 15 |
35550919 | Cysteine metabolism and hydrogen sulfide signaling in Huntington's disease. | 2022 Jun |
1 |
| 16 |
35563194 | Fighting the Huntington's Disease with a G-Quadruplex-Forming Aptamer Specifically Binding to Mutant Huntingtin Protein: Biophysical Characterization, In Vitro and In Vivo Studies. | 2022 Apr 27 |
1 |
| 17 |
35628660 | Analysis of Huntington's Disease Modifiers Using the Hyperbolic Mapping of the Protein Interaction Network. | 2022 May 23 |
4 |
| 18 |
35631226 | Phospholipid Profiles Are Selectively Altered in the Putamen and White Frontal Cortex of Huntington's Disease. | 2022 May 16 |
8 |
| 19 |
32235053 | The phasor FLIM method reveals a link between a change in energy metabolism and mHtt protein spread in healthy Mammalian cells when co-cultured with Huntington diseased cells. | 2021 Jan 11 |
2 |
| 20 |
33130095 | Lipid headgroups alter huntingtin aggregation on membranes. | 2021 Jan 1 |
1 |
| 21 |
33285261 | Mitochondrial SIRT3 confers neuroprotection in Huntington's disease by regulation of oxidative challenges and mitochondrial dynamics. | 2021 Feb 1 |
2 |
| 22 |
33517535 | Developmental malformations in Huntington disease: neuropathologic evidence of focal neuronal migration defects in a subset of adult brains. | 2021 Mar |
3 |
| 23 |
33576152 | SEL1L degradation intermediates stimulate cytosolic aggregation of polyglutamine-expanded protein. | 2021 Aug |
1 |
| 24 |
33644966 | Probing the Interaction of Huntingtin Exon-1 Polypeptides with the Chaperonin Nanomachine GroEL. | 2021 Jun 2 |
1 |
| 25 |
33659724 | In silico designing of putative peptides for targeting pathological protein Htt in Huntington's disease. | 2021 Feb |
3 |
| 26 |
33712450 | The p97-UBXN1 complex regulates aggresome formation. | 2021 Apr 1 |
1 |
| 27 |
33730050 | Reduction of WDR81 impairs autophagic clearance of aggregated proteins and cell viability in neurodegenerative phenotypes. | 2021 Mar |
3 |
| 28 |
33753744 | A modular tool to query and inducibly disrupt biomolecular condensates. | 2021 Mar 22 |
1 |
| 29 |
33767215 | The difficulty to model Huntington's disease in vitro using striatal medium spiny neurons differentiated from human induced pluripotent stem cells. | 2021 Mar 25 |
1 |
| 30 |
33809220 | The Novel Alpha-2 Adrenoceptor Inhibitor Beditin Reduces Cytotoxicity and Huntingtin Aggregates in Cell Models of Huntington's Disease. | 2021 Mar 12 |
1 |
| 31 |
33809947 | In Silico Analysis of Huntingtin Homologs in Lower Eukaryotes. | 2021 Mar 22 |
2 |
| 32 |
33869222 | Molecular Components of Store-Operated Calcium Channels in the Regulation of Neural Stem Cell Physiology, Neurogenesis, and the Pathology of Huntington's Disease. | 2021 |
2 |
| 33 |
33874957 | Human Huntington's disease pluripotent stem cell-derived microglia develop normally but are abnormally hyper-reactive and release elevated levels of reactive oxygen species. | 2021 Apr 19 |
1 |
| 34 |
33907289 | The heat shock response, determined by QuantiGene multiplex, is impaired in HD mouse models and not caused by HSF1 reduction. | 2021 Apr 27 |
1 |
| 35 |
33909994 | Pathological polyQ expansion does not alter the conformation of the Huntingtin-HAP40 complex. | 2021 Aug 5 |
5 |
| 36 |
33941067 | Normalization of Calcium Balance in Striatal Neurons in Huntington's Disease: Sigma 1 Receptor as a Potential Target for Therapy. | 2021 Apr |
1 |
| 37 |
34089719 | Mitochondrial membranes modify mutant huntingtin aggregation. | 2021 Oct 1 |
4 |
| 38 |
34161085 | A New Chemoenzymatic Semisynthetic Approach Provides Insight into the Role of Phosphorylation beyond Exon1 of Huntingtin and Reveals N-Terminal Fragment Length-Dependent Distinct Mechanisms of Aggregation. | 2021 Jul 7 |
2 |
| 39 |
34191328 | Increased levels of mitochondrial import factor Mia40 prevent the aggregation of polyQ proteins in the cytosol. | 2021 Aug 16 |
1 |
| 40 |
34201610 | Membrane Interactions Accelerate the Self-Aggregation of Huntingtin Exon 1 Fragments in a Polyglutamine Length-Dependent Manner. | 2021 Jun 23 |
1 |
| 41 |
34207177 | Purine Nucleotides Metabolism and Signaling in Huntington's Disease: Search for a Target for Novel Therapies. | 2021 Jun 18 |
3 |
| 42 |
34239038 | Cryo-electron tomography provides topological insights into mutant huntingtin exon 1 and polyQ aggregates. | 2021 Jul 8 |
2 |
| 43 |
34246856 | Macromolecular crowding in solution alters huntingtin interaction and aggregation at interfaces. | 2021 Oct |
5 |
| 44 |
34406601 | Glyceraldehyde-3-Phosphate Dehydrogenase Facilitates Macroautophagic Degradation of Mutant Huntingtin Protein Aggregates. | 2021 Nov |
2 |
| 45 |
34563643 | Amplification of neurotoxic HTTex1 assemblies in human neurons. | 2021 Nov |
4 |
| 46 |
34573100 | Signaling Overlap between the Golgi Stress Response and Cysteine Metabolism in Huntington's Disease. | 2021 Sep 15 |
2 |
| 47 |
34659371 | The MID1 Protein: A Promising Therapeutic Target in Huntington's Disease. | 2021 |
4 |
| 48 |
34718744 | Formation and persistence of polyglutamine aggregates in mistranslating cells. | 2021 Nov 18 |
2 |
| 49 |
34721539 | A Systematic Review of Transcriptional Dysregulation in Huntington's Disease Studied by RNA Sequencing. | 2021 |
1 |
| 50 |
34732320 | N-alpha-acetylation of Huntingtin protein increases its propensity to aggregate. | 2021 Dec |
6 |