polyglutamine

cag ; Drosophila melanogaster







24 Article(s)
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1 33744321 The S6k/4E-BP mediated growth promoting sub-pathway of insulin signalling cascade is essential to restrict pathogenesis of poly(Q) disorders in Drosophila. 2021 Jun 15 2
2 34077532 Toxicity of pathogenic ataxin-2 in Drosophila shows dependence on a pure CAG repeat sequence. 2021 Sep 15 3
3 34563642 Targeting the VCP-binding motif of ataxin-3 improves phenotypes in Drosophila models of Spinocerebellar Ataxia Type 3. 2021 Dec 1
4 30593503 AQAMAN, a bisamidine-based inhibitor of toxic protein inclusions in neurons, ameliorates cytotoxicity in polyglutamine disease models. 2019 Feb 22 2
5 30711541 Deregulated Splicing Is a Major Mechanism of RNA-Induced Toxicity in Huntington's Disease. 2019 Apr 19 1
6 31310802 Differential toxicity of ataxin-3 isoforms in Drosophila models of Spinocerebellar Ataxia Type 3. 2019 Dec 2
7 29476013 Karyopherin α-3 is a key protein in the pathogenesis of spinocerebellar ataxia type 3 controlling the nuclear localization of ataxin-3. 2018 Mar 13 1
8 26517966 Expression of polyQ aggregates in Malpighian tubules leads to degeneration in Drosophila melanogaster. 2016 Jan 1 2
9 26962150 A small-molecule Nrf1 and Nrf2 activator mitigates polyglutamine toxicity in spinal and bulbar muscular atrophy. 2016 May 15 1
10 25954029 DnaJ-1 and karyopherin α3 suppress degeneration in a new Drosophila model of Spinocerebellar Ataxia Type 6. 2015 Aug 1 2
11 24179173 Systems biology analysis of Drosophila in vivo screen data elucidates core networks for DNA damage repair in SCA1. 2014 Mar 1 1
12 26331033 Alleviating neurodegeneration in Drosophila models of PolyQ diseases. 2014 2
13 23382971 Sodium valproate alleviates neurodegeneration in SCA3/MJD via suppressing apoptosis and rescuing the hypoacetylation levels of histone H3 and H4. 2013 2
14 23719906 Morphometric analysis of Huntington's disease neurodegeneration in Drosophila. 2013 1
15 23812869 Lithium chloride alleviates neurodegeneration partly by inhibiting activity of GSK3β in a SCA3 Drosophila model. 2013 Dec 2
16 21949352 Protein interacting with C kinase (PICK1) is a suppressor of spinocerebellar ataxia 3-associated neurodegeneration in Drosophila. 2012 Jan 1 2
17 22021427 Comparative toxicity of polyglutamine, polyalanine and polyleucine tracts in Drosophila models of expanded repeat disease. 2012 Feb 1 1
18 22337953 Expanded ATXN3 frameshifting events are toxic in Drosophila and mammalian neuron models. 2012 May 15 1
19 23171848 Dysregulation of core components of SCF complex in poly-glutamine disorders. 2012 Nov 22 2
20 21041558 Defining genetic factors that modulate intergenerational CAG repeat instability in Drosophila melanogaster. 2011 Jan 2
21 21933837 Genes and pathways affected by CAG-repeat RNA-based toxicity in Drosophila. 2011 Dec 15 2
22 19667761 RNAi for the large non-coding hsromega transcripts suppresses polyglutamine pathogenesis in Drosophila models. 2009 Sep-Oct 1
23 18449188 RNA toxicity is a component of ataxin-3 degeneration in Drosophila. 2008 Jun 19 3
24 15757976 The pathogenic agent in Drosophila models of 'polyglutamine' diseases. 2005 Apr 15 1