Paroxetine

G protein-coupled receptor kinase 2 ; Homo sapiens







20 Article(s)
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1 33158816 Inhibition of G Protein-Coupled Receptor Kinase 2 Promotes Unbiased Downregulation of IGF1 Receptor and Restrains Malignant Cell Growth. 2021 Jan 15 4
2 33372534 Paroxetine Attenuates Cardiac Hypertrophy Via Blocking GRK2 and ADRB1 Interaction in Hypertension. 2021 Jan 5 3
3 33568523 Paroxetine-mediated GRK2 inhibition is a disease-modifying treatment for osteoarthritis. 2021 Feb 10 1
4 34259826 Effect of Paroxetine-Mediated G-Protein Receptor Kinase 2 Inhibition vs Placebo in Patients With Anterior Myocardial Infarction: A Randomized Clinical Trial. 2021 Oct 1 1
5 34386323 Targeted inhibition of GRK2 kinase domain by CP-25 to reverse fibroblast-like synoviocytes dysfunction and improve collagen-induced arthritis in rats. 2021 Jul 1
6 35155607 Paroxetine and Mortality in Heart Failure: A Retrospective Cohort Study. 2021 1
7 32234810 A New Paroxetine-Based GRK2 Inhibitor Reduces Internalization of the μ-Opioid Receptor. 2020 Jun 1
8 31506468 Computational study of paroxetine-like inhibitors reveals new molecular insight to inhibit GRK2 with selectivity over ROCK1. 2019 Sep 10 2
9 29980659 Small-Molecule G Protein-Coupled Receptor Kinase Inhibitors Attenuate G Protein-Coupled Receptor Kinase 2-Mediated Desensitization of Vasoconstrictor-Induced Arterial Contractions. 2018 Sep 2
10 30018141 GRK2 mediates TCR-induced transactivation of CXCR4 and TCR-CXCR4 complex formation that drives PI3Kγ/PREX1 signaling and T cell cytokine secretion. 2018 Sep 7 1
11 30366961 S1P1 receptor phosphorylation, internalization, and interaction with Rab proteins: effects of sphingosine 1-phosphate, FTY720-P, phorbol esters, and paroxetine. 2018 Dec 21 1
12 30463058 Development of Inflammatory Immune Response-Related Drugs Based on G Protein-Coupled Receptor Kinase 2. 2018 1
13 27222484 Hypothesis: Paroxetine, a G Protein-Coupled Receptor Kinase 2 (GRK2) Inhibitor Reduces Morbidity and Mortality in Patients With Heart Failure. 2017 Jan 4
14 28323425 Structure-Based Design of Highly Selective and Potent G Protein-Coupled Receptor Kinase 2 Inhibitors Based on Paroxetine. 2017 Apr 13 1
15 28349925 Paroxetine alleviates T lymphocyte activation and infiltration to joints of collagen-induced arthritis. 2017 Mar 28 1
16 29070696 Structural Determinants Influencing the Potency and Selectivity of Indazole-Paroxetine Hybrid G Protein-Coupled Receptor Kinase 2 Inhibitors. 2017 Dec 3
17 27695334 Effects of paroxetine-mediated inhibition of GRK2 expression on depression and cardiovascular function in patients with myocardial infarction. 2016 5
18 27999776 "Freeze, Don't Move": How to Arrest a Suspect in Heart Failure - A Review on Available GRK2 Inhibitors. 2016 1
19 24220010 Structural and functional analysis of g protein-coupled receptor kinase inhibition by paroxetine and a rationally designed analog. 2014 Feb 5
20 25340299 Identification and characterization of amlexanox as a G protein-coupled receptor kinase 5 inhibitor. 2014 Oct 22 1