dinaciclib

cyclin dependent kinase 2 ; Homo sapiens







22 Article(s)
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1 35053380 Phosphorylation-Induced Ubiquitination and Degradation of PXR through CDK2-TRIM21 Axis. 2022 Jan 13 1
2 34688130 Synthesis of a new series of pyrazolo[1,5-a]pyrimidines as CDK2 inhibitors and anti-leukemia. 2021 Dec 2
3 31529315 Accumulated cytotoxicity of CDK inhibitor dinaciclib with first-line chemotherapy drugs in salivary adenoid cystic carcinoma cells. 2020 Apr 1
4 32368395 Inhibition of CDK2 reduces EZH2 phosphorylation and reactivates ERα expression in high-grade serous ovarian carcinoma. 2020 2
5 32395375 Protein Phosphatase 1H, Cyclin-Dependent Kinase Inhibitor p27, and Cyclin-Dependent Kinase 2 in Paclitaxel Resistance for Triple Negative Breast Cancers. 2020 Apr 1
6 32433863 Cooperativity Between Orthosteric Inhibitors and Allosteric Inhibitor 8-Anilino-1-Naphthalene Sulfonic Acid (ANS) in Cyclin-Dependent Kinase 2. 2020 Jul 17 2
7 33050377 Significance of Targeting VEGFR-2 and Cyclin D1 in Luminal-A Breast Cancer. 2020 Oct 10 1
8 33116269 Dinaciclib, a cyclin-dependent kinase inhibitor, suppresses cholangiocarcinoma growth by targeting CDK2/5/9. 2020 Oct 28 1
9 31439587 PARP Inhibition Suppresses GR-MYCN-CDK5-RB1-E2F1 Signaling and Neuroendocrine Differentiation in Castration-Resistant Prostate Cancer. 2019 Nov 15 1
10 29507054 Targeting CDK2 overcomes melanoma resistance against BRAF and Hsp90 inhibitors. 2018 Mar 5 2
11 28107181 Cyclin E overexpression as a biomarker for combination treatment strategies in inflammatory breast cancer. 2017 Feb 28 1
12 28249908 Kinome-Wide RNA Interference Screen Reveals a Role for PDK1 in Acquired Resistance to CDK4/6 Inhibition in ER-Positive Breast Cancer. 2017 May 1 1
13 28947566 Cytoplasmic Cyclin E Mediates Resistance to Aromatase Inhibitors in Breast Cancer. 2017 Dec 1 2
14 29137354 ERpS294 is a biomarker of ligand or mutational ERα activation and a breast cancer target for CDK2 inhibition. 2017 Oct 13 1
15 27378523 Multiple CDK inhibitor dinaciclib suppresses neuroblastoma growth via inhibiting CDK2 and CDK9 activity. 2016 Jul 5 4
16 27550941 Dinaciclib Induces Anaphase Catastrophe in Lung Cancer Cells via Inhibition of Cyclin-Dependent Kinases 1 and 2. 2016 Nov 1
17 25395429 Dinaciclib, a novel CDK inhibitor, demonstrates encouraging single-agent activity in patients with relapsed multiple myeloma. 2015 Jan 15 1
18 25947565 A phase 1 study with dose expansion of the CDK inhibitor dinaciclib (SCH 727965) in combination with epirubicin in patients with metastatic triple negative breast cancer. 2015 Aug 1
19 25962959 Cyclin-dependent kinase inhibitor dinaciclib potently synergizes with cisplatin in preclinical models of ovarian cancer. 2015 Jun 20 1
20 25217392 Clinical study of the novel cyclin-dependent kinase inhibitor dinaciclib in combination with rituximab in relapsed/refractory chronic lymphocytic leukemia patients. 2014 Nov 1
21 24007471 Cyclin-dependent kinase inhibitor dinaciclib interacts with the acetyl-lysine recognition site of bromodomains. 2013 Nov 15 2
22 23053255 Effect of aprepitant on the pharmacokinetics of the cyclin-dependent kinase inhibitor dinaciclib in patients with advanced malignancies. 2012 Dec 1