sapropterin

nitric oxide synthase 2 ; Homo sapiens







113 Article(s)
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1 35431403 Marginal BH4 deficiencies, iNOS, and self-perpetuating oxidative stress in post-acute sequelae of Covid-19. 2022 Jun 2
2 34513700 The Critical Role of Tetrahydrobiopterin (BH4) Metabolism in Modulating Radiosensitivity: BH4/NOS Axis as an Angel or a Devil. 2021 2
3 31628042 PTPS Facilitates Compartmentalized LTBP1 S-Nitrosylation and Promotes Tumor Growth under Hypoxia. 2020 Jan 2 1
4 32112882 Correction of arginine metabolism with sepiapterin-the precursor of nitric oxide synthase cofactor BH4-induces immunostimulatory-shift of breast cancer. 2020 Jun 3
5 32574435 Nitric oxide in exhaled gas and tetrahydrobiopterin in plasma after exposure to hyperoxia. 2020 Second Quarter 2
6 31454684 Imbalance between nitric oxide and superoxide anion induced by uncoupled nitric oxide synthase contributes to human melanoma development. 2019 Oct 2
7 26778769 Genetic predisposition in patients with hypertension and normal ejection fraction to oxidative stress. 2016 Feb 1
8 25764397 Impaired systemic tetrahydrobiopterin bioavailability and increased dihydrobiopterin in adult falciparum malaria: association with disease severity, impaired microvascular function and increased endothelial activation. 2015 Mar 2
9 26669076 [Tetrahydrobiopterin Synthesis and Biological Function]. 2015 Aug 2
10 24180387 Tetrahydrobiopterin regulation of eNOS redox function. 2014 2
11 24491428 6R-l-erythro-5,6,7,8-tetrahydrobiopterin (BH4): a potential treatment for all symptom domains of schizophrenia. 2014 Mar 1
12 25139660 Recent developments in the effects of nitric oxide-donating statins on cardiovascular disease through regulation of tetrahydrobiopterin and nitric oxide. 2014 Nov 2
13 25548592 Tetrahydrobiopterin improves endothelial function in cardiovascular disease: a systematic review. 2014 2
14 23241881 Ascorbate in aqueous humor augments nitric oxide production by macrophages. 2013 Jan 15 3
15 23385656 Hyperoxia but not ambient pressure decreases tetrahydrobiopterin level without affecting the enzymatic capability of nitric oxide synthase in human endothelial cells. 2013 Jul 2
16 23441062 Tetrahydrobiopterin in nitric oxide synthase. 2013 Apr 1
17 23739137 Role of tetrahydrobiopterin in pulmonary vascular remodelling associated with pulmonary fibrosis. 2013 Oct 2
18 23743404 Oral sapropterin acutely augments reflex vasodilation in aged human skin through nitric oxide-dependent mechanisms. 2013 Oct 1 2
19 23774601 The intracellular environment of human macrophages that produce nitric oxide promotes growth of mycobacteria. 2013 Sep 1
20 24067187 Oxidative stress in hypobaric hypoxia and influence on vessel-tone modifying mediators. 2013 Sep 2
21 23052970 The role of tetrahydrobiopterin in inflammation and cardiovascular disease. 2012 Nov 3
22 21458460 Targeting endothelial and myocardial dysfunction with tetrahydrobiopterin. 2011 Oct 2
23 21867484 Tetrahydrobiopterin: biochemistry and pathophysiology. 2011 Sep 15 2
24 19932078 Reactive oxygen and nitrogen species regulate inducible nitric oxide synthase function shifting the balance of nitric oxide and superoxide production. 2010 Feb 15 2
25 20669954 Nitric oxide synthase stabilizes the tetrahydrobiopterin cofactor radical by controlling its protonation state. 2010 Aug 25 1
26 20846489 Maintenance of cellular tetrahydrobiopterin homeostasis. 2010 Sep 2
27 18582560 WITHDRAWN: Roles of tetrahydrobiopterin (BH4) cofactor in nitric oxide synthase (NOS) catalysis. 2009 Mar 27 2
28 19059356 The solution electrochemistry of tetrahydrobiopterin revisited. 2009 Mar 1
29 19294699 Proteomic analysis of GTP cyclohydrolase 1 multiprotein complexes in cultured normal adult human astrocytes under both basal and cytokine-activated conditions. 2009 Apr 1
30 19307452 Sepiapterin decreases acute rejection and apoptosis in cardiac transplants independently of changes in nitric oxide and inducible nitric-oxide synthase dimerization. 2009 Jun 2
31 19319842 Nitric oxide and vascular insulin resistance. 2009 Jan-Feb 1
32 18054268 Hydrogen peroxide stimulates tetrahydrobiopterin synthesis through activation of the Jak2 tyrosine kinase pathway in vascular endothelial cells. 2008 2
33 18283102 Catalytic reduction of a tetrahydrobiopterin radical within nitric-oxide synthase. 2008 Apr 25 1
34 18372436 Over-expression of GTP-cyclohydrolase 1 feedback regulatory protein attenuates LPS and cytokine-stimulated nitric oxide production. 2008 Feb 1
35 17191137 Tetrahydrobiopterin availability in Parkinson's and Alzheimer's disease; potential pathogenic mechanisms. 2007 Apr-May 1
36 17319660 Compound I of nitric oxide synthase: the active site protonation state. 2007 Mar 21 1
37 17448611 Nitric oxide synthase partial uncoupling as a key switching mechanism for the NO/ONOO- cycle. 2007 1
38 16641207 Developmental regulation of GTP-CH1 in the porcine lung and its relationship to pulmonary vascular relaxation. 2006 Jun 2
39 16702930 Cardioprotective effects of tetrahydrobiopterin in cold heart preservation after cardiac arrest. 2006 Apr 2
40 16946131 Tetrahydrobiopterin and cardiovascular disease. 2006 Nov 3
41 15290118 Tetrahydrobiopterin restores impaired coronary microvascular dysfunction in hypercholesterolaemia. 2005 Jan 1
42 15471981 Exogenous NO suppresses flow-induced endothelium-derived NO production because of depletion of tetrahydrobiopterin. 2005 Feb 2
43 15565652 BH(4) (tetrahydrobiopterin)-dependent activation, but not the expression, of inducible NOS (nitric oxide synthase)-2 in proinflammatory cytokine-stimulated, cultured normal human astrocytes is mediated by MEK-ERK kinases. 2005 Mar 1 3
44 15753231 Recent advances in the regulation of nitric oxide in the kidney. 2005 Jun 1
45 15933248 Mechanisms of inducible nitric oxide synthase-mediated vascular dysfunction. 2005 Aug 7
46 16052472 Roles of Ca2+ and the Ca2+-sensing receptor (CASR) in the expression of inducible NOS (nitric oxide synthase)-2 and its BH4 (tetrahydrobiopterin)-dependent activation in cytokine-stimulated adult human astrocytes. 2005 Oct 1 5
47 16172396 Monomeric inducible nitric oxide synthase localizes to peroxisomes in hepatocytes. 2005 Sep 27 2
48 16244500 Evidence for a tetrahydrobiopterin deficit in schizophrenia. 2005 1
49 16291253 Tetrahydrobiopterin as combined electron/proton donor in nitric oxide biosynthesis: cryogenic UV-Vis and EPR detection of reaction intermediates. 2005 2
50 14594819 Dynamic regulation of the inducible nitric-oxide synthase by NO: comparison with the endothelial isoform. 2004 Feb 6 1