Heme

nitric oxide synthase 2 ; Homo sapiens







83 Article(s)
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1 35326427 Hsp90 in Human Diseases: Molecular Mechanisms to Therapeutic Approaches. 2022 Mar 12 2
2 35513289 Hypochlorous acid facilitates inducible nitric oxide synthase subunit dissociation: The link between heme destruction, disturbance of the zinc-tetrathiolate center, and the prevention by melatonin. 2022 Jul 1 3
3 34313417 Endogenous Hemoprotein-Dependent Signaling Pathways of Nitric Oxide and Nitrite. 2021 Nov 1 1
4 33057871 An isoform-specific pivot modulates the electron transfer between the flavin mononucleotide and heme centers in inducible nitric oxide synthase. 2020 Dec 6
5 30244056 Physiological relevance of nitric oxide in ovarian functions: An overview. 2019 Aug 1 1
6 29751215 A docked state conformational dynamics model to explain the ionic strength dependence of FMN - heme electron transfer in nitric oxide synthase. 2018 Jul 3
7 29772550 Exploring the conformations of nitric oxide synthase with fluorescence. 2018 Jun 1 1
8 29904908 Role of an isoform-specific residue at the calmodulin-heme (NO synthase) interface in the FMN - heme electron transfer. 2018 Jul 4
9 28074650 Revisiting the Val/Ile Mutation in Mammalian and Bacterial Nitric Oxide Synthases: A Spectroscopic and Kinetic Study. 2017 Feb 7 1
10 27633182 Role of a Conserved Tyrosine Residue in the FMN-Heme Interdomain Electron Transfer in Inducible Nitric Oxide Synthase. 2016 Oct 6 1
11 26277414 Insight into structural rearrangements and interdomain interactions related to electron transfer between flavin mononucleotide and heme in nitric oxide synthase: A molecular dynamics study. 2015 Dec 4
12 26477677 Solving Kinetic Equations for the Laser Flash Photolysis Experiment on Nitric Oxide Synthases: Effect of Conformational Dynamics on the Interdomain Electron Transfer. 2015 Nov 12 1
13 25194416 Identification of redox partners and development of a novel chimeric bacterial nitric oxide synthase for structure activity analyses. 2014 Oct 17 1
14 25653844 Fourier transform infrared spectroscopy study of ligand photodissociation and migration in inducible nitric oxide synthase. 2014 4
15 23263357 Insights into the structural determinants for selective inhibition of nitric oxide synthase isoforms. 2013 Apr 1
16 23570607 Regulatory role of Glu546 in flavin mononucleotide-heme electron transfer in human inducible nitric oxide synthase. 2013 May 6 3
17 23696643 Mechanism of inducible nitric-oxide synthase dimerization inhibition by novel pyrimidine imidazoles. 2013 Jul 5 2
18 22407542 Role of an isoform-specific serine residue in FMN-heme electron transfer in inducible nitric oxide synthase. 2012 Jun 1
19 22457359 Thioredoxin-1 regulates cellular heme insertion by controlling S-nitrosation of glyceraldehyde-3-phosphate dehydrogenase. 2012 May 11 4
20 23123728 Synthesis, biological evaluation and molecular docking studies of 3-(triazolyl)-coumarin derivatives: effect on inducible nitric oxide synthase. 2012 Dec 1
21 21357526 Hsp90 interacts with inducible NO synthase client protein in its heme-free state and then drives heme insertion by an ATP-dependent process. 2011 Jun 8
22 21714930 Artesunate potentiates antibiotics by inactivating heme-harbouring bacterial nitric oxide synthase and catalase. 2011 Jun 30 1
23 21718007 Mutation in the flavin mononucleotide domain modulates magnetic circular dichroism spectra of the iNOS ferric cyano complex in a substrate-specific manner. 2011 Aug 1 1
24 21803041 Effect of solution viscosity on intraprotein electron transfer between the FMN and heme domains in inducible nitric oxide synthase. 2011 Aug 19 1
25 21834532 Pulsed ENDOR determination of relative orientation of g-frame and molecular frame of imidazole-coordinated heme center of iNOS. 2011 Sep 22 1
26 19790248 Visible light induces nitric oxide (NO) formation in sperm and endothelial cells. 2010 Apr 1
27 20006999 How does a valine residue that modulates heme-NO binding kinetics in inducible NO synthase regulate enzyme catalysis? 2010 Mar 1
28 20307068 Pterin-centered radical as a mechanistic probe of the second step of nitric oxide synthase. 2010 Apr 14 2
29 20501634 The effects of azole-based heme oxygenase inhibitors on rat cytochromes P450 2E1 and 3A1/2 and human cytochromes P450 3A4 and 2D6. 2010 Sep 1 1
30 20659888 Nitric-oxide synthase forms N-NO-pterin and S-NO-cys: implications for activity, allostery, and regulation. 2010 Oct 8 1
31 20695464 Pulsed EPR determination of the distance between heme iron and FMN centers in a human inducible nitric oxide synthase. 2010 Sep 1 2
32 20868689 Electron transfer in a human inducible nitric oxide synthase oxygenase/FMN construct co-expressed with the N-terminal globular domain of calmodulin. 2010 Oct 22 1
33 20921417 GAPDH regulates cellular heme insertion into inducible nitric oxide synthase. 2010 Oct 19 5
34 18830722 Intraprotein electron transfer in inducible nitric oxide synthase holoenzyme. 2009 Jan 1
35 19388666 Synthesis of nitric oxide by the NOS-like protein from deinococcus radiodurans: a direct role for tetrahydrofolate. 2009 Jun 16 1
36 19658411 Characterization of the proximal ligand in the P420 form of inducible nitric oxide synthase. 2009 Sep 2 2
37 19691141 Fast ferrous heme-NO oxidation in nitric oxide synthases. 2009 Aug 1
38 18178668 BYK191023 (2-[2-(4-methoxy-pyridin-2-yl)-ethyl]-3h-imidazo[4,5-b]pyridine) is an NADPH- and time-dependent irreversible inhibitor of inducible nitric-oxide synthase. 2008 Apr 1
39 18237198 Revisiting heme mechanisms. A perspective on the mechanisms of nitric oxide synthase (NOS), Heme oxygenase (HO), and cytochrome P450s (CYP450s). 2008 Feb 26 2
40 19759857 Probing the heme-thiolate oxygenase domain of inducible nitric oxide synthase with Ru(II) and Re(I) electron tunneling wires. 2008 Sep 1 1
41 17536854 Probing heme coordination states of inducible nitric oxide synthase with a ReI(imidazole-alkyl-nitroarginine) sensitizer-wire. 2007 Jun 21 2
42 17973404 Distal Val346Ile mutation in inducible NO synthase promotes substrate-dependent NO confinement. 2007 Nov 27 1
43 16431112 Design, synthesis, and biological testing of potential heme-coordinating nitric oxide synthase inhibitors. 2006 May 1 1
44 17173379 Inhibition of cytochrome P450 3A4 by a pyrimidineimidazole: Evidence for complex heme interactions. 2006 Dec 1
45 15656623 Mechanism of inactivation of inducible nitric oxide synthase by amidines. Irreversible enzyme inactivation without inactivator modification. 2005 Jan 26 5
46 16006534 Visualizing inducible nitric-oxide synthase in living cells with a heme-binding fluorescent inhibitor. 2005 Jul 19 1
47 15066989 Heme distortion modulated by ligand-protein interactions in inducible nitric-oxide synthase. 2004 Jun 18 2
48 15219988 CO exchange of the oxyferrous complexes of endothelial nitric-oxide synthase oxygenase domain in the presence of 4-amino-tetrahydrobiopterin. 2004 Jul 1
49 14514694 Single-turnover of nitric-oxide synthase in the presence of 4-amino-tetrahydrobiopterin: proposed role for tetrahydrobiopterin as a proton donor. 2003 Dec 5 1
50 14609340 Ability of tetrahydrobiopterin analogues to support catalysis by inducible nitric oxide synthase: formation of a pterin radical is required for enzyme activity. 2003 Nov 18 1