Adenosine Triphosphate

cyclin dependent kinase 5 ; Homo sapiens







28 Article(s)
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1 32660255 Cdk5-Mediated Phosphorylation of Sirt1 Contributes to Podocyte Mitochondrial Dysfunction in Diabetic Nephropathy. 2021 Jan 20 1
2 33931002 Exploring multi-target inhibitors using in silico approach targeting cell cycle dysregulator-CDK proteins. 2021 Apr 30 1
3 34182065 Pharmacological relevance of CDK inhibitors in Alzheimer's disease. 2021 Sep 1
4 32974274 Identification of Quinazolinone Analogs Targeting CDK5 Kinase Activity and Glioblastoma Cell Proliferation. 2020 3
5 31073393 Computational Simulations Identified Two Candidate Inhibitors of Cdk5/p25 to Abrogate Tau-associated Neurological Disorders. 2019 3
6 31137734 Computational Simulations Identify Pyrrolidine-2,3-Dione Derivatives as Novel Inhibitors of Cdk5/p25 Complex to Attenuate Alzheimer's Pathology. 2019 May 24 1
7 31163256 Myricetin prevents thapsigargin-induced CDK5-P66Shc signalosome mediated pancreatic β-cell dysfunction. 2019 Sep 1
8 30079618 Amino acid sequence conservation of the algesic fragment of myelin basic protein is required for its interaction with CDK5 and function in pain. 2018 Sep 1
9 28868329 Active Cdk5 Immunoprecipitation and Kinase Assay. 2017 Jul 5 1
10 29856575 [Progress in the study of new cancer target Cdk5 and its inhibitors]. 2016 Feb 1
11 24704205 Acetylation of cyclin-dependent kinase 5 is mediated by GCN5. 2014 Apr 25 2
12 24983862 Investigation of the flexibility of protein kinases implicated in the pathology of Alzheimer's disease. 2014 Jun 30 2
13 24998602 Synthesis and biological evaluation of tetrahydro[1,4]diazepino[1,2-a]indol-1-ones as cyclin-dependent kinase inhibitors. 2014 Aug 18 1
14 25438765 Discovery of thienoquinolone derivatives as selective and ATP non-competitive CDK5/p25 inhibitors by structure-based virtual screening. 2014 Nov 15 2
15 27481520 Binding Mechanism of Inhibitors to CDK5/p25 Complex: Free Energy Calculation and Ranking Aggregation Analysis. 2013 Mar 2
16 21641213 Novel purine-based fluoroaryl-1,2,3-triazoles as neuroprotecting agents: synthesis, neuronal cell culture investigations, and CDK5 docking studies. 2011 Jul 1 1
17 21681969 An in silico approach for the discovery of CDK5/p25 interaction inhibitors. 2011 Jul 2
18 20491486 Kinetic mechanistic studies of Cdk5/p25-catalyzed H1P phosphorylation: metal effect and solvent kinetic isotope effect. 2010 Jun 15 2
19 18636751 Kinetic studies of Cdk5/p25 kinase: phosphorylation of tau and complex inhibition by two prototype inhibitors. 2008 Aug 12 1
20 18220519 New approaches to the discovery of cdk5 inhibitors. 2007 Dec 2
21 14761195 Structural basis for the synthesis of indirubins as potent and selective inhibitors of glycogen synthase kinase-3 and cyclin-dependent kinases. 2004 Feb 12 1
22 12112670 Identification of the N-terminal functional domains of Cdk5 by molecular truncation and computer modeling. 2002 Aug 15 3
23 12372407 Molecular model of cyclin-dependent kinase 5 complexed with roscovitine. 2002 Oct 11 1
24 11604388 The cyclin-dependent kinases cdk2 and cdk5 act by a random, anticooperative kinetic mechanism. 2001 Dec 21 1
25 10998059 Paullones are potent inhibitors of glycogen synthase kinase-3beta and cyclin-dependent kinase 5/p25. 2000 Oct 1
26 11054815 Phosphorylation of human tau protein by microtubule-associated kinases: GSK3beta and cdk5 are key participants. 2000 Nov 1 1
27 10362524 A model of the complex between cyclin-dependent kinase 5 and the activation domain of neuronal Cdk5 activator. 1999 Jun 7 2
28 7592534 Evidence for cdk5 as a major activity phosphorylating tau protein in porcine brain extract. 1995 Apr 2