Nickel

hypoxia inducible factor 1 subunit alpha ; Homo sapiens







43 Article(s)
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1 33740985 Effects of metal nanoparticles on tight junction-associated proteins via HIF-1α/miR-29b/MMPs pathway in human epidermal keratinocytes. 2021 Mar 19 1
2 34571076 Nickel chloride regulates ANGPTL4 via the HIF-1α-mediated TET1 expression in lung cells. 2021 Nov 1 1
3 31804169 Nickel and Oxidative Stress: Cell Signaling Mechanisms and Protective Role of Vitamin C. 2020 1
4 31963541 Metformin Mitigates Nickel-Elicited Angiopoietin-Like Protein 4 Expression via HIF-1α for Lung Tumorigenesis. 2020 Jan 17 3
5 32566089 Melatonin Antagonizes Nickel-Induced Aerobic Glycolysis by Blocking ROS-Mediated HIF-1α/miR210/ISCU Axis Activation. 2020 5
6 29355601 Nickel ions bind to HSP90β and enhance HIF-1α-mediated IL-8 expression. 2018 Feb 15 1
7 28004401 Hypoxia-inducible factors as neuroprotective agent in Alzheimer's disease. 2017 Mar 1
8 28263966 LncRNA MEG3 downregulation mediated by DNMT3b contributes to nickel malignant transformation of human bronchial epithelial cells via modulating PHLPP1 transcription and HIF-1α translation. 2017 Jul 6 4
9 28552779 Nickel-induced HIF-1α promotes growth arrest and senescence in normal human cells but lacks toxic effects in transformed cells. 2017 Sep 15 1
10 25614230 A not cytotoxic nickel concentration alters the expression of neuronal differentiation markers in NT2 cells. 2015 Mar 2
11 26051273 Nickel inhibits mitochondrial fatty acid oxidation. 2015 Aug 7 4
12 24497960 Cobalt and nickel stabilize stem cell transcription factor OCT4 through modulating its sumoylation and ubiquitination. 2014 1
13 23526216 Role of hypoxia-inducible factor 1, α subunit and cAMP-response element binding protein 1 in synergistic release of interleukin 8 by prostaglandin E2 and nickel in lung fibroblasts. 2013 Jul 1
14 23828170 Identification of molecular candidates and interaction networks via integrative toxicogenomic analysis in a human cell line following low-dose exposure to the carcinogenic metals cadmium and nickel. 2013 Sep 1
15 32260803 Structural characterisation of hypoxia-mimicking bioactive glasses. 2013 Mar 7 1
16 22910906 The requirement of c-Jun N-terminal kinase 2 in regulation of hypoxia-inducing factor-1α mRNA stability. 2012 Oct 5 2
17 21401309 The role of hypoxia inducible factor-1α in the increased MMP-2 and MMP-9 production by human monocytes exposed to nickel nanoparticles. 2011 Dec 1
18 21828359 Bioavailability, intracellular mobilization of nickel, and HIF-1α activation in human lung epithelial cells exposed to metallic nickel and nickel oxide nanoparticles. 2011 Nov 1
19 22133446 Nickel ENMs activate HIF-1α. 2011 Dec 1
20 18832182 Nickel and the microbial toxin, MALP-2, stimulate proangiogenic mediators from human lung fibroblasts via a HIF-1alpha and COX-2-mediated pathway. 2009 Jan 1
21 19505905 Effects of nickel on cyclin expression, cell cycle progression and cell proliferation in human pulmonary cells. 2009 Jun 1
22 20046830 Mechanisms of c-myc degradation by nickel compounds and hypoxia. 2009 Dec 31 2
23 17312168 The contact allergen nickel triggers a unique inflammatory and proangiogenic gene expression pattern via activation of NF-kappaB and hypoxia-inducible factor-1alpha. 2007 Mar 1 4
24 17382205 The role of ascorbate in the modulation of HIF-1alpha protein and HIF-dependent transcription by chromium(VI) and nickel(II). 2007 Apr 15 2
25 16288478 Ascorbate depletion mediates up-regulation of hypoxia-associated proteins by cell density and nickel. 2006 Apr 1 1
26 16649251 Soluble nickel inhibits HIF-prolyl-hydroxylases creating persistent hypoxic signaling in A549 cells. 2006 Jul 4
27 16877034 Effect of metal ions on HIF-1alpha and Fe homeostasis in human A549 cells. 2006 Nov 7 1
28 15866766 Ascorbate depletion: a critical step in nickel carcinogenesis? 2005 May 1
29 16039939 Nickel decreases cellular iron level and converts cytosolic aconitase to iron-regulatory protein 1 in A549 cells. 2005 Aug 15 2
30 16283525 Soluble nickel interferes with cellular iron homeostasis. 2005 Nov 4
31 16705796 Down-regulation of the expression of the FIH-1 and ARD-1 genes at the transcriptional level by nickel and cobalt in the human lung adenocarcinoma A549 cell line. 2005 Apr 2
32 14726713 HIF-1: an oxygen and metal responsive transcription factor. 2004 Jan 1
33 14729612 Nickel compounds act through phosphatidylinositol-3-kinase/Akt-dependent, p70(S6k)-independent pathway to induce hypoxia inducible factor transactivation and Cap43 expression in mouse epidermal Cl41 cells. 2004 Jan 1 4
34 12729255 GeneChip analysis of signaling pathways effected by nickel. 2003 Apr 2
35 12839937 The involvement of hypoxia-inducible transcription factor-1-dependent pathway in nickel carcinogenesis. 2003 Jul 1 12
36 14645679 Hypoxia inducible factor-1 alpha-independent suppression of aryl hydrocarbon receptor-regulated genes by nickel. 2003 Dec 1
37 11779168 Cobalt- and nickel-binding property of cullin-2. 2002 Jan 11 2
38 12426141 The role of hypoxia-inducible signaling pathway in nickel carcinogenesis. 2002 Oct 8
39 11504687 Nickel requires hypoxia-inducible factor-1 alpha, not redox signaling, to induce plasminogen activator inhibitor-1. 2001 Sep 6
40 11739637 A new HIF-1 alpha variant induced by zinc ion suppresses HIF-1-mediated hypoxic responses. 2001 Nov 2
41 10646848 Carcinogenic nickel induces genes involved with hypoxic stress. 2000 Jan 1 6
42 10679259 Zinc induces the accumulation of hypoxia-inducible factor (HIF)-1alpha, but inhibits the nuclear translocation of HIF-1beta, causing HIF-1 inactivation. 2000 Feb 16 1
43 10469629 Nickel-induced transformation shifts the balance between HIF-1 and p53 transcription factors. 1999 Sep 1