| 51 |
18694926 | Identification of an alternative mechanism of degradation of the hypoxia-inducible factor-1alpha. | 2008 Oct 24 |
3 |
| 52 |
18980686 | Non-synonymous sequence variants within the oxygen-dependent degradation domain of the HIF1A gene are not associated with pre-eclampsia in the Finnish population. | 2008 Nov 3 |
1 |
| 53 |
19240858 | Effect of HIF1A gene polymorphism on human muscle performance. | 2008 Sep |
3 |
| 54 |
17189520 | Hypoxia-inducible factors in the first trimester human lung. | 2007 Apr |
1 |
| 55 |
17406354 | The p53 codon 72 proline allele is endowed with enhanced cell-death inducing potential in cancer cells exposed to hypoxia. | 2007 Apr 23 |
1 |
| 56 |
17412315 | Nitric oxide and superoxide: interference with hypoxic signaling. | 2007 Jul 15 |
1 |
| 57 |
17551816 | HIF-1 mediates the Warburg effect in clear cell renal carcinoma. | 2007 Jun |
2 |
| 58 |
16139409 | Differential responses of two degradation domains of HIF-1alpha to hypoxia and iron deficiency. | 2006 Feb |
3 |
| 59 |
16176182 | Analysis of the hypoxia-sensing pathway in Drosophila melanogaster. | 2006 Jan 15 |
1 |
| 60 |
16611863 | Dynamic HIF1A regulation during human placental development. | 2006 Jul |
1 |
| 61 |
16753841 | Peroxynitrite as an alternative donor of oxygen in HIF-1alpha proline hydroxylation under low oxygen availability. | 2006 Jun |
2 |
| 62 |
16837101 | C2028T polymorphism in exon 12 and dinucleotide repeat polymorphism in intron 13 of the HIF-1alpha gene define HIF-1alpha protein expression in non-small cell lung cancer. | 2006 Sep |
1 |
| 63 |
17002676 | Hypoxia-induced erythropoietin production: a paradigm for oxygen-regulated gene expression. | 2006 Oct |
1 |
| 64 |
17172857 | Degradation of the hypoxia-inducible factor 1alpha: where does it happen? | 2006 Dec |
1 |
| 65 |
15538748 | Identification of hypoxia-inducible factor-1alpha (HIF-1alpha) polymorphism as a mutation in prostate cancer that prevents normoxia-induced degradation. | 2005 May 15 |
1 |
| 66 |
15878343 | Activation of hypoxia-induced transcription in normoxia. | 2005 May 15 |
2 |
| 67 |
16024780 | Coordinate regulation of the oxygen-dependent degradation domains of hypoxia-inducible factor 1 alpha. | 2005 Aug |
5 |
| 68 |
16100168 | Hypoxia-inducible factor 1alpha polymorphism and coronary collaterals in patients with ischemic heart disease. | 2005 Aug |
1 |
| 69 |
16155211 | Inhibition of the catalytic activity of hypoxia-inducible factor-1alpha-prolyl-hydroxylase 2 by a MYND-type zinc finger. | 2005 Dec |
2 |
| 70 |
16182243 | A fluorescence polarization-based interaction assay for hypoxia-inducible factor prolyl hydroxylases. | 2005 Nov 11 |
1 |
| 71 |
14984367 | Endogenous 2-oxoacids differentially regulate expression of oxygen sensors. | 2004 Jun 1 |
1 |
| 72 |
15084514 | Leu-574 of human HIF-1alpha is a molecular determinant of prolyl hydroxylation. | 2004 Jun |
2 |
| 73 |
15104534 | Hypoxia-inducible factor-1 (HIF-1) promotes its degradation by induction of HIF-alpha-prolyl-4-hydroxylases. | 2004 Aug 1 |
1 |
| 74 |
15271983 | Depletion of intracellular ascorbate by the carcinogenic metals nickel and cobalt results in the induction of hypoxic stress. | 2004 Sep 24 |
1 |
| 75 |
15350301 | Polymorphisms in the hypoxia inducible factor-1alpha gene (HIF1A) are associated with the renal cell carcinoma phenotype. | 2004 Sep |
1 |
| 76 |
15485863 | Many amino acid substitutions in a hypoxia-inducible transcription factor (HIF)-1alpha-like peptide cause only minor changes in its hydroxylation by the HIF prolyl 4-hydroxylases: substitution of 3,4-dehydroproline or azetidine-2-carboxylic acid for the proline leads to a high rate of uncoupled 2-oxoglutarate decarboxylation. | 2004 Dec 31 |
1 |
| 77 |
12393546 | Mutations in the VHL gene in sporadic apparently congenital polycythemia. | 2003 Feb 15 |
2 |
| 78 |
12538644 | Multiple splice variants of the human HIF-3 alpha locus are targets of the von Hippel-Lindau E3 ubiquitin ligase complex. | 2003 Mar 28 |
1 |
| 79 |
12586829 | Cyclosporin A prevents the hypoxic adaptation by activating hypoxia-inducible factor-1alpha Pro-564 hydroxylation. | 2003 Apr 25 |
1 |
| 80 |
12649278 | Activation of the prolyl hydroxylase oxygen-sensor results in induction of GLUT1, heme oxygenase-1, and nitric-oxide synthase proteins and confers protection from metabolic inhibition to cardiomyocytes. | 2003 May 30 |
2 |
| 81 |
12670503 | Differential regulation of HIF-1 alpha prolyl-4-hydroxylase genes by hypoxia in human cardiovascular cells. | 2003 Apr 11 |
1 |
| 82 |
12873125 | Proline- and arginine-rich peptides constitute a novel class of allosteric inhibitors of proteasome activity. | 2003 Jul 29 |
1 |
| 83 |
14521712 | A common polymorphism in the oxygen-dependent degradation (ODD) domain of hypoxia inducible factor-1alpha (HIF-1alpha) does not impair Pro-564 hydroxylation. | 2003 Sep 9 |
1 |
| 84 |
12124396 | Two sequence motifs from HIF-1alpha bind to the DNA-binding site of p53. | 2002 Aug 6 |
2 |
| 85 |
12181324 | Sequence determinants in hypoxia-inducible factor-1alpha for hydroxylation by the prolyl hydroxylases PHD1, PHD2, and PHD3. | 2002 Oct 18 |
2 |
| 86 |
12186875 | Role of prolyl hydroxylation in oncogenically stabilized hypoxia-inducible factor-1alpha. | 2002 Oct 18 |
4 |
| 87 |
12195866 | Oxygen homeostasis and cancer: insights from a rare disease. | 2002 Jul-Aug |
1 |
| 88 |
12205091 | Leu-574 of HIF-1alpha is essential for the von Hippel-Lindau (VHL)-mediated degradation pathway. | 2002 Nov 1 |
1 |
| 89 |
11292861 | Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation. | 2001 Apr 20 |
2 |
| 90 |
11504942 | HIF-1alpha binding to VHL is regulated by stimulus-sensitive proline hydroxylation. | 2001 Aug 14 |
1 |