fasudil

Rho associated coiled-coil containing protein kinase 1 ; Homo sapiens







15 Article(s)
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1 33278350 Targeting ROCK1/2 blocks cell division and induces mitotic catastrophe in hepatocellular carcinoma. 2021 Feb 1
2 33779714 Fasudil alleviated insulin resistance through promotion of proliferation, attenuation of cell apoptosis and inflammation and regulation of RhoA/Rho kinase/insulin/nuclear factor-κB signalling pathway in HTR-8/SVneo cells. 2021 Jul 7 1
3 32619776 Computational systematic selectivity of the Fasalog inhibitors between ROCK-I and ROCK-II kinase isoforms in Alzheimer's disease. 2020 Jun 22 1
4 32829478 Design of novel ROCK inhibitors using fragment-based de novo drug design approach. 2020 Aug 22 1
5 33633690 Tissue-Specific Approaches Reveal Diverse Metabolic Functions of Rho-Kinase 1. 2020 1
6 30044647 Synthesis and pharmacological evaluation of novel isoquinoline N-sulphonylhydrazones designed as ROCK inhibitors. 2018 Dec 1
7 28225457 RhoA/ROCK pathway inhibition by fasudil suppresses the vasculogenic mimicry of U2OS osteosarcoma cells in vitro. 2017 Jun 3
8 28510599 Selective inhibition of brain endothelial Rho-kinase-2 provides optimal protection of an in vitro blood-brain barrier from tissue-type plasminogen activator and plasmin. 2017 1
9 28841710 Inhibition of ROCK1 kinase modulates both tumor cells and stromal fibroblasts in pancreatic cancer. 2017 1
10 25931586 RNAi profiling of primary human AML cells identifies ROCK1 as a therapeutic target and nominates fasudil as an antileukemic drug. 2015 Jun 11 1
11 26481340 Role of Rho Kinase and Fasudil on Synaptic Plasticity in Multiple Sclerosis. 2015 Dec 1
12 25400825 Involvement of RhoA/ROCK1 signaling pathway in hyperglycemia-induced microvascular endothelial dysfunction in diabetic retinopathy. 2014 1
13 23094262 Dexamethasone inhibits U937 cell adhesion via the down-regulation of ROCK1 activity. 2012 1
14 21917869 Fasudil inhibits the proliferation and contractility and induces cell cycle arrest and apoptosis of human endometriotic stromal cells: a promising agent for the treatment of endometriosis. 2011 Dec 2
15 22041269 [The effect of fasudil via Rho/ROCK signaling pathway on the inflammation and fibrosis in human mesangial cells in high glucose medium]. 2011 Jul 2