N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide

prostaglandin-endoperoxide synthase 2 ; Homo sapiens







360 Article(s)
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1 34864006 Fisetin suppresses cigarette smoke extract-induced epithelial to mesenchymal transition of airway epithelial cells through regulating COX-2/MMPs/β-catenin pathway. 2022 Jan 5 1
2 35103990 Photodynamic Therapy-Induced Cyclooxygenase 2 Expression in Tumor-Draining Lymph Nodes Regulates B-Cell Expression of Interleukin 17 and Neutrophil Infiltration. 2022 Feb 1 2
3 35163465 Up-Regulation of Cyclooxygenase-2 (COX-2) Expression by Temozolomide (TMZ) in Human Glioblastoma (GBM) Cell Lines. 2022 Jan 28 1
4 34122616 Ghrelin Regulates Cyclooxygenase-2 Expression and Promotes Gastric Cancer Cell Progression. 2021 2
5 32435158 Biological effects of selective COX-2 inhibitor NS398 on human glioblastoma cell lines. 2020 2
6 32456093 Valproic Acid Impacts the Growth of Growth Plate Chondrocytes. 2020 May 22 2
7 32753632 The prostaglandin synthases, COX-2 and L-PGDS, mediate prostate hyperplasia induced by low-dose bisphenol A. 2020 Aug 4 1
8 33240646 Deregulation of lysophosphatidic acid metabolism in oral cancer promotes cell migration via the up-regulation of COX-2. 2020 2
9 30862036 Cyclooxygenase-2-Mediated Up-Regulation of Mitochondrial Transcription Factor A Mitigates the Radio-Sensitivity of Cancer Cells. 2019 Mar 11 1
10 31115011 COX-2 potentiates cisplatin resistance of non-small cell lung cancer cells by promoting EMT in an AKT signaling pathway-dependent manner. 2019 May 1
11 31473257 JmjC domain-containing protein 8 (JMJD8) represses Ku70/Ku80 expression via attenuating AKT/NF-κB/COX-2 signaling. 2019 Dec 2
12 31485669 COX‑2 promotes epithelial‑mesenchymal transition and migration in osteosarcoma MG‑63 cells via PI3K/AKT/NF‑κB signaling. 2019 Oct 1
13 28987401 PM2.5 exposure stimulates COX-2-mediated excitatory synaptic transmission via ROS-NF-κB pathway. 2018 Jan 1
14 29700305 The therapeutic effect of miR-125b is enhanced by the prostaglandin endoperoxide synthase 2/cyclooxygenase 2 blockade and hampers ETS1 in the context of the microenvironment of bone metastasis. 2018 May 1 1
15 30085341 Cyclooxygenase‑2‑mediated upregulation of heme oxygenase 1 mitigates the toxicity of deuterium‑tritium fusion radiation. 2018 Oct 2
16 30420588 Expression and Molecular Regulation of the Cox2 Gene in Gastroenteropancreatic Neuroendocrine Tumors and Antiproliferation of Nonsteroidal Anti-Inflammatory Drugs (NSAIDs). 2018 Nov 13 1
17 28032559 Bradykinin stimulates protein kinase D-mediated colonic myofibroblast migration via cyclooxygenase-2 and heat shock protein 27. 2017 Mar 1
18 28179576 KIAA1199 is induced by inflammation and enhances malignant phenotype in pancreatic cancer. 2017 Mar 7 1
19 28223053 Diabetes Upregulation of Cyclooxygenase 2 Contributes to Altered Coronary Reactivity After Cardiac Surgery. 2017 Aug 1
20 28446249 Adipose-derived mesenchymal stem cells modulate CD14++CD16+ expression on monocytes from sepsis patients in vitro via prostaglandin E2. 2017 Apr 26 2
21 28628921 Activation of COX-2/mPGES-1/PGE2 Cascade via NLRP3 Inflammasome Contributes to Albumin-Induced Proximal Tubule Cell Injury. 2017 2
22 28638310 Analysis of Gene Expression in Human Dermal Fibroblasts Treated with Senescence-Modulating COX Inhibitors. 2017 Jun 2
23 28668332 Ethanol-induced PGE2 up-regulates Aβ production through PKA/CREB signaling pathway. 2017 Nov 2
24 28985857 Cyclooxygenase 2 contributes to bradykinin-induced microvascular responses in peripheral arterioles after cardiopulmonary bypass. 2017 Oct 2
25 26756900 COX-2 inhibitor NS-398 suppresses doxorubicin-induced p53 accumulation through inhibition of ROS-mediated Jnk activation. 2016 Dec 2
26 26863638 Lovastatin lactone elicits human lung cancer cell apoptosis via a COX-2/PPARγ-dependent pathway. 2016 Mar 1 2
27 27312705 Novel effects of the cyclooxygenase-2-selective inhibitor NS-398 on IL-1β-induced cyclooxygenase-2 and IL-8 expression in human ovarian granulosa cells. 2016 Aug 2
28 27681882 Immunomodulatory effects of nicotine on interleukin 1β activated human astrocytes and the role of cyclooxygenase 2 in the underlying mechanism. 2016 Sep 29 2
29 27798865 Co-treatment with Celecoxib or NS398 Strongly Sensitizes Resistant Cancer Cells to Antimitotic Drugs Independent of P-gp Inhibition. 2016 Oct 1
30 25201048 Sphingosine-1-phosphate mediates COX-2 expression and PGE2 /IL-6 secretion via c-Src-dependent AP-1 activation. 2015 Mar 1
31 25351115 Withaferin A induces apoptosis through the generation of thiol oxidation in human head and neck cancer cells. 2015 Jan 1
32 25540231 Colon distention induces persistent visceral hypersensitivity by mechanotranscription of pain mediators in colonic smooth muscle cells. 2015 Mar 1 1
33 25553117 Parthenolide inhibits cancer stem-like side population of nasopharyngeal carcinoma cells via suppression of the NF-κB/COX-2 pathway. 2015 1
34 25711465 Melatonin-mediated Bim up-regulation and cyclooxygenase-2 (COX-2) down-regulation enhances tunicamycin-induced apoptosis in MDA-MB-231 cells. 2015 Apr 2
35 26036283 Mono-ethylhexyl phthalate stimulates prostaglandin secretion in human placental macrophages and THP-1 cells. 2015 Jun 3 2
36 26066979 COX2 is involved in hypoxia-induced TNF-α expression in osteoblast. 2015 Jun 12 3
37 26281984 Retraction Note to: Effect of NS-398, a cyclooxygenase-2 selective inhibitor, on the cytotoxicity of cytotoxic T lymphocytes to ovarian carcinoma cells. 2015 Sep 1
38 26351820 Exogenous hydrogen sulfide promotes C6 glioma cell growth through activation of the p38 MAPK/ERK1/2-COX-2 pathways. 2015 Nov 1
39 26604791 miR-21 inhibits the effects of cyclooxygenase-2 inhibitor NS398 on apoptosis and invasion in gastric cancer cells. 2015 2
40 24561081 Cyclic tensile force up-regulates BMP-2 expression through MAP kinase and COX-2/PGE2 signaling pathways in human periodontal ligament cells. 2014 Apr 15 2
41 24692712 COX2 inhibitor NS398 reduces HT-29 cell invasiveness by modulating signaling pathways mediated by EGFR and HIF1-α. 2014 Apr 3
42 24710938 Cyclooxygenase-2 blockade inhibits accumulation and function of myeloid-derived suppressor cells and restores T cell response after traumatic stress. 2014 Apr 1
43 25174821 Naringin inhibits growth and induces apoptosis by a mechanism dependent on reduced activation of NF‑κB/COX‑2‑caspase-1 pathway in HeLa cervical cancer cells. 2014 Nov 1
44 25310697 Inflammation and MiR-21 pathways functionally interact to downregulate PDCD4 in colorectal cancer. 2014 1
45 25343626 TRAIL-mediated apoptosis in breast cancer cells cultured as 3D spheroids. 2014 2
46 23053901 The down-regulation of Notch1 inhibits the invasion and migration of hepatocellular carcinoma cells by inactivating the cyclooxygenase-2/Snail/E-cadherin pathway in vitro. 2013 Apr 1
47 23095809 Involvement of the P2X7 purinergic receptor and c-Jun N-terminal and extracellular signal-regulated kinases in cyclooxygenase-2 and prostaglandin E2 induction by LL-37. 2013 1
48 23398724 High expression of cyclooxygenase-2 in uterine fibroids and its correlation with cell proliferation. 2013 Jun 1
49 23456767 Effect of NS-398, a cyclooxygenase-2 selective inhibitor, on the cytotoxicity of cytotoxic T lymphocytes to ovarian carcinoma cells. 2013 Jun 2
50 23495037 Mechanisms of ceramide-induced COX-2-dependent apoptosis in human ovarian cancer OVCAR-3 cells partially overlapped with resveratrol. 2013 Aug 3