Thiazolidinediones

peroxisome proliferator-activated receptor gamma ; Rattus norvegicus







92 Article(s)
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1 33030290 A Series of Ferulic Acid Amides Reveals Unexpected Peroxiredoxin 1 Inhibitory Activity with in vivo Antidiabetic and Hypolipidemic Effects. 2021 Feb 4 1
2 34233552 Pioglitazone improves skeletal muscle functions in reserpine-induced fibromyalgia rat model. 2021 Dec 2
3 31968546 PPARγ-Independent Side Effects of Thiazolidinediones on Mitochondrial Redox State in Rat Isolated Hearts. 2020 Jan 20 1
4 33100954 Two Rationally Identified Novel Glitazones Reversed the Behavioral Dysfunctions and Exhibited Neuroprotection Through Ameliorating Brain Cytokines and Oxy-Radicals in ICV-LPS Neuroinflammatory Rat Model. 2020 5
5 31204468 Oxadiazolyl thiazolidinedione as a non-adipogenic PPAR-γ partial agonist and its effect on glucose homeostasis in type 2 diabetes. 2019 May-Jun 1
6 31685649 Activation of PPARγ Attenuates the Expression of Physical and Affective Nicotine Withdrawal Symptoms through Mechanisms Involving Amygdala and Hippocampus Neurotransmission. 2019 Dec 4 1
7 29244961 Time-dependent therapeutic roles of nitazoxanide on high-fat diet/streptozotocin-induced diabetes in rats: effects on hepatic peroxisome proliferator-activated receptor-gamma receptors. 2018 May 1
8 28202347 In silico design, chemical synthesis and toxicological evaluation of 1,3-thiazolidine-2,4-dione derivatives as PPARγ agonists. 2017 Jun 1
9 28928054 Effect of the antidiabetic agent pioglitazone on bone metabolism in rats. 2017 Sep 4
10 29296174 A novel thiazolidinediones ATZD2 rescues memory deficits in a rat model of type 2 diabetes through antioxidant and antiinflammation. 2017 Dec 8 3
11 26643379 AMP-Activated Protein Kinase Mediates the Antiplatelet Effects of the Thiazolidinediones Rosiglitazone and Pioglitazone. 2016 Feb 2
12 24683546 Rosiglitazone increases cerebral klotho expression to reverse baroreflex in type 1-like diabetic rats. 2014 2
13 23194750 Reversible inhibition of vasoconstriction by thiazolidinediones related to PI3K/Akt inhibition in vascular smooth muscle cells. 2013 Feb 15 4
14 23906789 PPARγ agonists upregulate sphingosine 1-phosphate (S1P) receptor 1 expression, which in turn reduces S1P-induced [Ca(2+)]i increases in renal mesangial cells. 2013 Nov 2
15 24164426 Metabonomic profiling revealed an alteration in purine nucleotide metabolism associated with cardiac hypertrophy in rats treated with thiazolidinediones. 2013 Dec 6 4
16 24304573 Comparison of anti-inflammatory properties of peroxisome proliferator-activated receptor gamma agonists rosiglitazone and troglitazone in prophylactic treatment of experimental colitis. 2013 Oct 2
17 22220498 Pioglitazone treatment increases COX-2-derived prostacyclin production and reduces oxidative stress in hypertensive rats: role in vascular function. 2012 Jun 1
18 22575275 Early induction of a brown-like phenotype by rosiglitazone in the epicardial adipose tissue of fatty Zucker rats. 2012 Aug 1
19 22970990 Chemical proteomics-based analysis of off-target binding profiles for rosiglitazone and pioglitazone: clues for assessing potential for cardiotoxicity. 2012 Oct 11 1
20 22995601 Treatment of rats with pioglitazone in the reperfusion phase of focal cerebral ischemia: a preclinical stroke trial. 2012 Dec 2
21 23388479 Comparison of the anti-inflammatory and therapeutic actions of PPAR-gamma agonists rosiglitazone and troglitazone in experimental colitis. 2012 Dec 1
22 21276964 Activation of nuclear PPARγ receptors by the antidiabetic agent pioglitazone suppresses alcohol drinking and relapse to alcohol seeking. 2011 Apr 1 1
23 21291492 Activation of peroxisome proliferator-activated receptor-γ downregulates soluble epoxide hydrolase in cardiomyocytes. 2011 Jun 6
24 21346152 Lipophilicity as a determinant of thiazolidinedione action in vitro: findings from BLX-1002, a novel compound without affinity to PPARs. 2011 Jun 3
25 21720019 Pharmacology and in vitro profiling of a novel peroxisome proliferator-activated receptor γ ligand, Cerco-A. 2011 4
26 19891980 Activation of peroxisome proliferator-activated receptor gamma in brain inhibits inflammatory pain, dorsal horn expression of Fos, and local edema. 2010 Feb 2
27 19954759 Opposite effects of two thiazolidinediones, ciglitazone and troglitazone, on proteinase-activated receptor-1-triggered prostaglandin E(2) release. 2010 Jan 31 2
28 20050918 3T3-L1 adipocyte apoptosis induced by thiazolidinediones is peroxisome proliferator-activated receptor-gamma-dependent and mediated by the caspase-3-dependent apoptotic pathway. 2010 Feb 3
29 20107770 Activation of PPARgamma by pioglitazone does not attenuate left ventricular hypertrophy following aortic banding in rats. 2010 Apr 2
30 20167487 Novel glitazones: design, synthesis, glucose uptake and structure-activity relationships. 2010 Mar 15 1
31 20691766 Extension of the neuroprotective time window for thiazolidinediones in ischemic stroke is dependent on time of reperfusion. 2010 Oct 27 3
32 19248225 Activation of PPARalpha and PPARgamma reduces triacylglycerol synthesis in rat hepatoma cells by reduction of nuclear SREBP-1. 2009 Mar 1 1
33 19261909 A rapid, PPAR-gamma-dependent effect of pioglitazone on the phosphorylation of MYPT. 2009 May 1
34 19297362 Antifibrotic effects of pioglitazone on the kidney in a rat model of type 2 diabetes mellitus. 2009 Aug 2
35 19333142 Rosiglitazone reduces the inflammatory response in a model of vascular injury in rats. 2009 Dec 1
36 19406947 Pioglitazone acutely reduces insulin secretion and causes metabolic deceleration of the pancreatic beta-cell at submaximal glucose concentrations. 2009 Aug 1
37 19483106 Peroxisome proliferator-activated receptor (PPAR)-gamma positively controls and PPARalpha negatively controls cyclooxygenase-2 expression in rat brain astrocytes through a convergence on PPARbeta/delta via mutual control of PPAR expression levels. 2009 Aug 1
38 19698699 Down-regulation of lipoprotein lipase increases glucose uptake in L6 muscle cells. 2009 Nov 6 1
39 21137009 Proteomic characterization of thiazolidinedione regulation of obese adipose secretome in Zucker obese rats. 2009 Sep 1
40 17995925 Correction of protein kinase C activity and macrophage migration in peripheral nerve by pioglitazone, peroxisome proliferator activated-gamma-ligand, in insulin-deficient diabetic rats. 2008 Jan 1
41 18199331 Anti-inflammatory effect of antidiabetic thiazolidinediones prevents bone resorption rather than cartilage changes in experimental polyarthritis. 2008 1
42 18360056 Pioglitazone, a thiazolidinedione derivative, attenuates left ventricular hypertrophy and fibrosis in salt-sensitive hypertension. 2008 Feb 1
43 18423377 Thiazolidinediones inhibit the growth of PC12 cells both in vitro and in vivo. 2008 Jun 27 2
44 18423937 PPAR-gamma expression in animals subjected to volume overload and chronic Urotensin II administration. 2008 May 1
45 18827362 Troglitazone increases IL-1beta induced cyclooxygenase-2 and inducible nitric oxide synthase expression via enhanced phosphorylation of IkappaBalpha in vascular smooth muscle cells from Wistar-Kyoto rats and spontaneously hypertensive rats. 2008 Oct 1
46 17074304 Rosiglitazone inhibits angiotensin II-induced CTGF expression in vascular smooth muscle cells - role of PPAR-gamma in vascular fibrosis. 2007 Jan 15 1
47 17167171 Thiazolidinedione class of peroxisome proliferator-activated receptor gamma agonists prevents neuronal damage, motor dysfunction, myelin loss, neuropathic pain, and inflammation after spinal cord injury in adult rats. 2007 Mar 4
48 17343847 Antinociceptive and antiedematogenic activities of fenofibrate, an agonist of PPAR alpha, and pioglitazone, an agonist of PPAR gamma. 2007 Apr 30 1
49 17374699 Telmisartan prevents the glitazone-induced weight gain without interfering with its insulin-sensitizing properties. 2007 Jul 1
50 17394460 Peroxisome proliferator-activated receptor-gamma agonists induce neuroprotection following transient focal ischemia in normotensive, normoglycemic as well as hypertensive and type-2 diabetic rodents. 2007 Apr 5