Tyrphostins

signal transducer and activator of transcription 3 ; Homo sapiens







16 Article(s)
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1 31846485 Tyrphostin AG490 reduces inflammation and fibrosis in neonatal obstructive nephropathy. 2019 1
2 28713982 Protective effects of SOCS3 overexpression in high glucose‑induced lung epithelial cell injury through the JAK2/STAT3 pathway. 2017 Sep 1
3 19564891 Enhancement of TRAIL cytotoxicity by AG-490 in human ALL cells is characterized by downregulation of cIAP-1 and cIAP-2 through inhibition of Jak2/Stat3. 2009 Sep 1
4 18855573 A potent anti-carcinoma and anti-acute myeloblastic leukemia agent, AG490. 2008 Oct 2
5 19010822 Mesothelin-induced pancreatic cancer cell proliferation involves alteration of cyclin E via activation of signal transducer and activator of transcription protein 3. 2008 Nov 1
6 19967068 Tyrphostin ErbB2 Inhibitors AG825 and AG879 Have Non-specific Suppressive Effects on gp130/ STAT3 Signaling. 2008 Oct 2
7 16517747 Pancreatitis-associated protein I suppresses NF-kappa B activation through a JAK/STAT-mediated mechanism in epithelial cells. 2006 Mar 15 1
8 15912144 STAT3 is essential for Hodgkin lymphoma cell proliferation and is a target of tyrphostin AG17 which confers sensitization for apoptosis. 2005 Jun 2
9 16706231 [EGF-dependent signaling pathways are activated under heat stress in A431 carcinoma cells]. 2005 1
10 12949733 Activated signal transducer and activator of transcription 3 (STAT3) supports the malignant phenotype of human pancreatic cancer. 2003 Sep 1
11 14580692 Blockade of constitutively activated Janus kinase/signal transducer and activator of transcription-3 pathway inhibits growth of human pancreatic cancer. 2003 Nov 10 1
12 12193593 5(S)-hydroxyeicosatetraenoic acid stimulates DNA synthesis in human microvascular endothelial cells via activation of Jak/STAT and phosphatidylinositol 3-kinase/Akt signaling, leading to induction of expression of basic fibroblast growth factor 2. 2002 Oct 25 1
13 11368440 Constitutive STAT3-activation in Sezary syndrome: tyrphostin AG490 inhibits STAT3-activation, interleukin-2 receptor expression and growth of leukemic Sezary cells. 2001 May 2
14 10728680 Inhibition of constitutively activated Stat3 signaling pathway suppresses growth of prostate cancer cells. 2000 Mar 1 1
15 10508495 ErbB-2 kinase is required for constitutive stat 3 activation in malignant human lung epithelial cells. 1999 Nov 12 1
16 9192639 Constitutive activation of a slowly migrating isoform of Stat3 in mycosis fungoides: tyrphostin AG490 inhibits Stat3 activation and growth of mycosis fungoides tumor cell lines. 1997 Jun 24 3