Cocaine

glutamate receptor, ionotropic, AMPA2 (alpha 2) ; Mus musculus







44 Article(s)
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1 34522005 mTOR regulates cocaine-induced behavioural sensitization through the SynDIG1-GluA2 interaction in the nucleus accumbens. 2022 Feb 3
2 35168076 Cannabidiol decreases motivation for cocaine in a behavioral economics paradigm but does not prevent incubation of craving in mice. 2022 Apr 1
3 34110073 Sex-specific role for prefrontal cortical protein interacting with C kinase 1 in cue-induced cocaine seeking. 2021 Sep 1
4 31364211 Role of BRD4 phosphorylation in the nucleus accumbens in relapse to cocaine-seeking behavior in mice. 2020 Sep 2
5 31705540 Prenatal and postnatal alcohol exposure increases vulnerability to cocaine addiction in adult mice. 2020 Mar 1
6 32102661 A new mouse line with reduced GluA2 Q/R site RNA editing exhibits loss of dendritic spines, hippocampal CA1-neuron loss, learning and memory impairments and NMDA receptor-independent seizure vulnerability. 2020 Feb 27 1
7 30948476 Synaptic Depotentiation and mGluR5 Activity in the Nucleus Accumbens Drive Cocaine-Primed Reinstatement of Place Preference. 2019 Jun 12 6
8 28137451 Intermittent intake of rapid cocaine injections promotes robust psychomotor sensitization, increased incentive motivation for the drug and mGlu2/3 receptor dysregulation. 2017 May 1 1
9 28668281 Disruption of GluA2 phosphorylation potentiates stress responsivity. 2017 Aug 30 6
10 28700935 Deletion of Type 2 Metabotropic Glutamate Receptor Decreases Sensitivity to Cocaine Reward in Rats. 2017 Jul 11 8
11 29029785 A single dose of cocaine potentiates glutamatergic synaptic transmission onto locus coeruleus neurons. 2017 Nov 2
12 26149611 Differential effects of the metabotropic glutamate 2/3 receptor agonist LY379268 on nicotine versus cocaine self-administration and relapse in squirrel monkeys. 2016 May 1
13 26585289 Cell-Type Specific Insertion of GluA2-Lacking AMPARs with Cocaine Exposure Leading to Sensitization, Cue-Induced Seeking, and Incubation of Craving. 2016 Jun 10
14 27122037 Epac Signaling Is Required for Cocaine-Induced Change in AMPA Receptor Subunit Composition in the Ventral Tegmental Area. 2016 Apr 27 7
15 27622930 Disrupting GluA2 phosphorylation potentiates reinstatement of cocaine seeking. 2016 Dec 13
16 23017017 Modafinil attenuates reinstatement of cocaine seeking: role for cystine-glutamate exchange and metabotropic glutamate receptors. 2014 Jan 2
17 25268136 Functional deficiency of MHC class I enhances LTP and abolishes LTD in the nucleus accumbens of mice. 2014 1
18 23624743 The mGluR2/3 agonist LY379268 induced anti-reinstatement effects in rats exhibiting addiction-like behavior. 2013 Sep 2
19 24183704 Expression of cocaine-evoked synaptic plasticity by GluN3A-containing NMDA receptors. 2013 Nov 20 1
20 21790902 (-)-2-oxa-4-aminobicylco[3.1.0]hexane-4,6-dicarboxylic acid (LY379268) and 3-[(2-methyl-1,3-thiazol-4-yl)ethynyl]piperidine (MTEP) similarly attenuate stress-induced reinstatement of cocaine seeking. 2012 May 1
21 21881873 Regulation of cocaine-induced reinstatement by group II metabotropic glutamate receptors in the ventral tegmental area. 2012 Mar 2
22 22197517 The rewarding and locomotor-sensitizing effects of repeated cocaine administration are distinct and separable in mice. 2012 Mar 1
23 22860224 Small molecule screening identifies regulators of the transcription factor ΔFosB. 2012 Jul 18 1
24 22956853 Cocaine evokes projection-specific synaptic plasticity of lateral habenula neurons. 2012 Sep 5 1
25 20868701 Effects of minocycline on cocaine sensitization and phosphorylation of GluR1 receptors in 5-lipoxygenase deficient mice. 2011 Jun 1
26 21155570 Design and synthesis of an orally active metabotropic glutamate receptor subtype-2 (mGluR2) positive allosteric modulator (PAM) that decreases cocaine self-administration in rats. 2011 Jan 13 2
27 21336270 Cocaine inverts rules for synaptic plasticity of glutamate transmission in the ventral tegmental area. 2011 Apr 1
28 21490215 Calcium-permeable AMPA receptors are present in nucleus accumbens synapses after prolonged withdrawal from cocaine self-administration but not experimenter-administered cocaine. 2011 Apr 13 3
29 19895667 Inhibition of NAALADase by 2-PMPA attenuates cocaine-induced relapse in rats: a NAAG-mGluR2/3-mediated mechanism. 2010 Jan 6
30 20416862 Behavioral and functional evidence of metabotropic glutamate receptor 2/3 and metabotropic glutamate receptor 5 dysregulation in cocaine-escalated rats: factor in the transition to dependence. 2010 Aug 1 1
31 20534005 Activation of mGluR7s inhibits cocaine-induced reinstatement of drug-seeking behavior by a nucleus accumbens glutamate-mGluR2/3 mechanism in rats. 2010 Sep 1 4
32 20555310 The mGluR2 positive allosteric modulator BINA decreases cocaine self-administration and cue-induced cocaine-seeking and counteracts cocaine-induced enhancement of brain reward function in rats. 2010 Sep 3
33 21209835 Drug-driven AMPA receptor redistribution mimicked by selective dopamine neuron stimulation. 2010 Dec 31 6
34 19084053 Computational model of extracellular glutamate in the nucleus accumbens incorporates neuroadaptations by chronic cocaine. 2009 Feb 18 2
35 19703487 Interactions between the mGluR2/3 agonist, LY379268, and cocaine on in vivo neurochemistry and behavior in squirrel monkeys. 2009 Nov 1
36 17895914 Rats with extended access to cocaine exhibit increased stress reactivity and sensitivity to the anxiolytic-like effects of the mGluR 2/3 agonist LY379268 during abstinence. 2008 Jul 1
37 19128205 Glutamate: the new frontier in pharmacotherapy for cocaine addiction. 2008 Nov 1
38 16582902 Cocaine triggered AMPA receptor redistribution is reversed in vivo by mGluR-dependent long-term depression. 2006 May 1
39 16703399 The group II metabotropic glutamate receptor agonist, LY379268, inhibits both cocaine- and food-seeking behavior in rats. 2006 Jun 3
40 16914679 Cannabinoid CB1 receptor antagonist AM251 inhibits cocaine-primed relapse in rats: role of glutamate in the nucleus accumbens. 2006 Aug 16 1
41 15753323 Enhanced cocaine responsiveness and impaired motor coordination in metabotropic glutamate receptor subtype 2 knockout mice. 2005 Mar 15 3
42 16000629 Cystine/glutamate exchange regulates metabotropic glutamate receptor presynaptic inhibition of excitatory transmission and vulnerability to cocaine seeking. 2005 Jul 6 1
43 12706249 Inducible, brain region-specific expression of a dominant negative mutant of c-Jun in transgenic mice decreases sensitivity to cocaine. 2003 Apr 25 1
44 12388642 Modulation of group II metabotropic glutamate receptor signaling by chronic cocaine. 2002 Nov 1