| 1 |
33555037 | TRV130 partial agonism and capacity to induce anti-nociceptive tolerance revealed through reducing available μ-opioid receptor number. | 2021 Apr |
1 |
| 2 |
33705801 | Role of β-arrestin-2 in short- and long-term opioid tolerance in the dorsal root ganglia. | 2021 May 15 |
3 |
| 3 |
34031190 | A20-Binding Inhibitor of Nuclear Factor-κB Targets β-Arrestin2 to Attenuate Opioid Tolerance. | 2021 Aug |
5 |
| 4 |
32854452 | Biased versus Partial Agonism in the Search for Safer Opioid Analgesics. | 2020 Aug 25 |
1 |
| 5 |
31057409 | A Review of the Therapeutic Potential of Recently Developed G Protein-Biased Kappa Agonists. | 2019 |
1 |
| 6 |
29713080 | Complex formation between the vasopressin 1b receptor, β-arrestin-2, and the μ-opioid receptor underlies morphine tolerance. | 2018 Jun |
1 |
| 7 |
28319053 | Alternatively spliced mu opioid receptor C termini impact the diverse actions of morphine. | 2017 Apr 3 |
2 |
| 8 |
28391016 | Fasting biases μ-opioid receptors toward β-arrestin2-dependent signaling in the accumbens shell. | 2017 Jun 3 |
1 |
| 9 |
28820778 | Src Kinase Inhibition Attenuates Morphine Tolerance without Affecting Reinforcement or Psychomotor Stimulation. | 2017 Nov |
1 |
| 10 |
28855588 | Morphine activation of mu opioid receptors causes disinhibition of neurons in the ventral tegmental area mediated by β-arrestin2 and c-Src. | 2017 Aug 30 |
3 |
| 11 |
24555516 | Enhancement of morphine analgesia and prevention of morphine tolerance by downregulation of β-arrestin 2 with antigene RNAs in mice. | 2015 Jan |
6 |
| 12 |
24597632 | β-Arrestin-2 knockout prevents development of cellular μ-opioid receptor tolerance but does not affect opioid-withdrawal-related adaptations in single PAG neurons. | 2015 Jan |
1 |
| 13 |
25083714 | Specific localization of β-Arrestin2 in myenteric plexus of mouse gastrointestinal tract. | 2014 |
1 |
| 14 |
25194025 | Morphine dependence in single enteric neurons from the mouse colon requires deletion of β-arrestin2. | 2014 Sep 1 |
4 |
| 15 |
27152166 | The physiological relevance of functional selectivity in dopamine signalling. | 2014 Jul |
2 |
| 16 |
23300227 | A G protein-biased ligand at the μ-opioid receptor is potently analgesic with reduced gastrointestinal and respiratory dysfunction compared with morphine. | 2013 Mar |
1 |
| 17 |
23960234 | Morphine prevents lipopolysaccharide-induced TNF secretion in mast cells blocking IκB kinase activation and SNAP-23 phosphorylation: correlation with the formation of a β-arrestin/TRAF6 complex. | 2013 Sep 15 |
2 |
| 18 |
24063433 | Structure-activity relationships and discovery of a G protein biased μ opioid receptor ligand, [(3-methoxythiophen-2-yl)methyl]({2-[(9R)-9-(pyridin-2-yl)-6-oxaspiro-[4.5]decan-9-yl]ethyl})amine (TRV130), for the treatment of acute severe pain. | 2013 Oct 24 |
1 |
| 19 |
24223972 | Influence of clonidine and ketamine on m-RNA expression in a model of opioid-induced hyperalgesia in mice. | 2013 |
2 |
| 20 |
22129596 | The role of β-arrestin2 in the mechanism of morphine tolerance in the mouse and guinea pig gastrointestinal tract. | 2012 Mar |
3 |
| 21 |
22491351 | Evidence that behavioral phenotypes of morphine in β-arr2-/- mice are due to the unmasking of JNK signaling. | 2012 Jul |
8 |
| 22 |
20980993 | A dopamine D1 receptor-dependent β-arrestin signaling complex potentially regulates morphine-induced psychomotor activation but not reward in mice. | 2011 Feb |
7 |
| 23 |
19854889 | mu-Opioid receptor agonists differentially regulate the expression of miR-190 and NeuroD. | 2010 Jan |
1 |
| 24 |
19399231 | Improvement of morphine-mediated analgesia by inhibition of β-arrestin2 expression in mice periaqueductal gray matter. | 2009 Mar |
3 |
| 25 |
19477204 | HIV-1 gp120 primes lymphocytes for opioid-induced, beta-arrestin 2-dependent apoptosis. | 2009 Aug |
1 |
| 26 |
19497686 | Morphine-induced physiological and behavioral responses in mice lacking G protein-coupled receptor kinase 6. | 2009 Oct 1 |
2 |
| 27 |
18558479 | Morphine-induced mu-opioid receptor rapid desensitization is independent of receptor phosphorylation and beta-arrestins. | 2008 Sep |
1 |
| 28 |
17090705 | An opioid agonist that does not induce mu-opioid receptor--arrestin interactions or receptor internalization. | 2007 Feb |
1 |
| 29 |
17494695 | Beta-arrestin2 and c-Src regulate the constitutive activity and recycling of mu opioid receptors in dorsal root ganglion neurons. | 2007 May 9 |
3 |
| 30 |
15788776 | Induction of delta-opioid receptor function in the midbrain after chronic morphine treatment. | 2005 Mar 23 |
1 |
| 31 |
15917400 | Morphine side effects in beta-arrestin 2 knockout mice. | 2005 Sep |
4 |
| 32 |
15346705 | Opioid tolerance: is there a dialogue between glutamate and beta-arrestin? | 2004 Jun |
1 |
| 33 |
14614085 | Enhanced rewarding properties of morphine, but not cocaine, in beta(arrestin)-2 knock-out mice. | 2003 Nov 12 |
6 |
| 34 |
12451149 | Differential mechanisms of morphine antinociceptive tolerance revealed in (beta)arrestin-2 knock-out mice. | 2002 Dec 1 |
5 |
| 35 |
11130073 | Mu-opioid receptor desensitization by beta-arrestin-2 determines morphine tolerance but not dependence. | 2000 Dec 7 |
1 |
| 36 |
10617462 | Enhanced morphine analgesia in mice lacking beta-arrestin 2. | 1999 Dec 24 |
3 |