Sirolimus

mechanistic target of rapamycin kinase ; Rattus norvegicus







284 Article(s)
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251 18094032 Low-dose mTOR inhibition by rapamycin attenuates progression in anti-thy1-induced chronic glomerulosclerosis of the rat. 2008 Feb 2
252 18094073 Interferon beta augments tuberous sclerosis complex 2 (TSC2)-dependent inhibition of TSC2-null ELT3 and human lymphangioleiomyomatosis-derived cell proliferation. 2008 Mar 2
253 18486258 Inhibition of mTOR in combination with doxorubicin in an experimental model of hepatocellular carcinoma. 2008 Jul 1
254 18651560 Induction of HIF-1alpha expression by intermittent hypoxia: involvement of NADPH oxidase, Ca2+ signaling, prolyl hydroxylases, and mTOR. 2008 Dec 1
255 18667775 [Effeet of rapamycin on mTOR and eIF-4E expression in coxsackievirus B3-induced rat myocardial cells]. 2008 Jul 3
256 19099956 [Effects of mTOR inhibitor rapamycin on Smad 3 protein and collagen type I expression in rat myocardial fibroblasts infected with coxsackie virus B 3]. 2008 Feb 1
257 17321636 Vascular remodeling and antitumoral effects of mTOR inhibition in a rat model of hepatocellular carcinoma. 2007 May 1
258 17389711 Rapamycin blunts nutrient stimulation of eIF4G, but not PKCepsilon phosphorylation, in skeletal muscle. 2007 Jul 1
259 17537394 Different signaling pathways utilized by insulin to regulate the expression of ENT2, CNT1, CNT2 nucleoside transporters in rat cardiac fibroblasts. 2007 Aug 15 1
260 17537841 Hyperglycemia impairs glucose and insulin regulation of nitric oxide production in glucose-inhibited neurons in the ventromedial hypothalamus. 2007 Aug 1
261 17541736 Myocardial ischaemia-reperfusion injury is attenuated by intact glucagon like peptide-1 (GLP-1) in the in vitro rat heart and may involve the p70s6K pathway. 2007 Aug 1
262 17634255 Rapamycin limits formation of active eukaryotic initiation factor 4F complex following meal feeding in rat hearts. 2007 Aug 2
263 17671379 Rapamycin prevents early steps of the development of diabetic nephropathy in rats. 2007 1
264 16221708 Inhibition of mTOR with sirolimus slows disease progression in Han:SPRD rats with autosomal dominant polycystic kidney disease (ADPKD). 2006 Mar 1
265 16597691 Mammalian target of rapamycin pathway blockade slows progression of diabetic kidney disease in rats. 2006 May 1
266 17050028 Low-dose oral rapamycin treatment reduces fibrogenesis, improves liver function, and prolongs survival in rats with established liver cirrhosis. 2006 Dec 1
267 15358595 EGF receptor transactivation mediates ANG II-stimulated mitogenesis in intestinal epithelial cells through the PI3-kinase/Akt/mTOR/p70S6K1 signaling pathway. 2005 Feb 1
268 15557109 Effects of rapamycin in the Eker rat model of tuberous sclerosis complex. 2005 Jan 3
269 15604215 Increased activation of the mammalian target of rapamycin pathway in liver and skeletal muscle of obese rats: possible involvement in obesity-linked insulin resistance. 2005 Mar 2
270 15692808 Regulation of insulin signalling by hyperinsulinaemia: role of IRS-1/2 serine phosphorylation and the mTOR/p70 S6K pathway. 2005 Mar 1
271 15868910 Inhibition of mTOR suppresses experimental liver tumours. 2005 Mar-Apr 1
272 14610086 Amino acids and insulin control autophagic proteolysis through different signaling pathways in relation to mTOR in isolated rat hepatocytes. 2004 Feb 27 1
273 14660591 Insulin promotes rat retinal neuronal cell survival in a p70S6K-dependent manner. 2004 Mar 5 2
274 14990989 Niban gene is commonly expressed in the renal tumors: a new candidate marker for renal carcinogenesis. 2004 Apr 22 1
275 15158453 Regulation of translation elongation and phosphorylation of eEF2 in rat pancreatic acini. 2004 Jun 18 1
276 15228089 Glucose-induced binding of the polypyrimidine tract-binding protein (PTB) to the 3'-untranslated region of the insulin mRNA (ins-PRS) is inhibited by rapamycin. 2004 May 1
277 15284343 Signalling mechanisms underlying the rapid and additive stimulation of NKCC activity by insulin and hypertonicity in rat L6 skeletal muscle cells. 2004 Oct 1 1
278 15313464 The mTOR signaling pathway mediates control of ribosomal protein mRNA translation in rat liver. 2004 Nov 2
279 15339861 Alterations in glucose metabolism by cyclosporine in rat brain slices link to oxidative stress: interactions with mTOR inhibitors. 2004 Oct 1
280 12646166 Branched-chain amino acids promote albumin synthesis in rat primary hepatocytes through the mTOR signal transduction system. 2003 Mar 28 1
281 12750770 IRS1 degradation and increased serine phosphorylation cannot predict the degree of metabolic insulin resistance induced by oxidative stress. 2003 May 1
282 12384518 Activated mammalian target of rapamycin pathway in the pathogenesis of tuberous sclerosis complex renal tumors. 2002 Oct 15 2
283 11015466 Leucine stimulates translation initiation in skeletal muscle of postabsorptive rats via a rapamycin-sensitive pathway. 2000 Oct 1
284 10437918 The zinc finger protein GLI induces cellular sensitivity to the mTOR inhibitor rapamycin. 1999 Jul 3