Sirolimus

mechanistic target of rapamycin kinase ; Rattus norvegicus







284 Article(s)
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151 27493704 Melatonin-Mediated Intracellular Insulin during 2-Deoxy-d-glucose Treatment Is Reduced through Autophagy and EDC3 Protein in Insulinoma INS-1E Cells. 2016 1
152 27555230 Role of mechanistic target of rapamycin (mTOR) in renal function and ischaemia-reperfusion induced kidney injury. 2016 Nov 3
153 27564518 Defective Autophagy in Diabetic Retinopathy. 2016 Aug 1 1
154 27755955 Rapamycin protects against neuronal death and improves neurological function with modulation of microglia after experimental intracerebral hemorrhage in rats. 2016 Sep 30 2
155 27776426 Tetrahydroxystilbene Glucoside Inhibits Excessive Autophagy and Improves Microvascular Endothelial Dysfunction in Prehypertensive Spontaneously Hypertensive Rats. 2016 2
156 27780878 Blocking mammalian target of rapamycin alleviates bladder hyperactivity and pain in rats with cystitis. 2016 1
157 27997905 Blocking Mammalian Target of Rapamycin (mTOR) Attenuates HIF-1α Pathways Engaged-Vascular Endothelial Growth Factor (VEGF) in Diabetic Retinopathy. 2016 1
158 28123835 Cerebral mTOR signal and pro-inflammatory cytokines in Alzheimer's disease rats. 2016 1
159 25034463 5-HT6 Receptor Recruitment of mTOR Modulates Seizure Activity in Epilepsy. 2015 1
160 25349217 Rapamycin ameliorates IgA nephropathy via cell cycle-dependent mechanisms. 2015 Jul 1
161 25440763 The dual mTORC1 and mTORC2 inhibitor PP242 shows strong antitumor activity in a pheochromocytoma PC12 cell tumor model. 2015 Jan 4
162 25924882 Profiling of the fetal and adult rat liver transcriptome and translatome reveals discordant regulation by the mechanistic target of rapamycin (mTOR). 2015 Jul 1 1
163 26048361 Restoration of Normal Cerebral Oxygen Consumption with Rapamycin Treatment in a Rat Model of Autism-Tuberous Sclerosis. 2015 Sep 2
164 26120832 A Critical Role of the mTOR/eIF2α Pathway in Hypoxia-Induced Pulmonary Hypertension. 2015 1
165 26150775 AMPA Receptor-mTOR Activation is Required for the Antidepressant-Like Effects of Sarcosine during the Forced Swim Test in Rats: Insertion of AMPA Receptor may Play a Role. 2015 2
166 26164831 Improved autophagic flux is correlated with mTOR activation in the later recovery stage of experimental acute pancreatitis. 2015 Sep-Oct 1
167 26175092 Inhibition of mTOR activity in diabetes mellitus reduces proteinuria but not renal accumulation of hyaluronan. 2015 1
168 26224775 Mammalian target of rapamycin is required for phrenic long-term facilitation following severe but not moderate acute intermittent hypoxia. 2015 Sep 1
169 26239133 The mammalian target of rapamycin modulates the immunoproteasome system in the heart. 2015 Sep 1
170 26248290 Effect of Chronic Administration of Low Dose Rapamycin on Development and Immunity in Young Rats. 2015 3
171 26297427 The Akt/mTOR/p70S6K pathway is activated in IgA nephropathy and rapamycin may represent a viable treatment option. 2015 Dec 1
172 26313913 Decreased autophagy: a major factor for cardiomyocyte death induced by β1-adrenoceptor autoantibodies. 2015 Aug 27 1
173 26341392 LY395756, an mGluR2 agonist and mGluR3 antagonist, enhances NMDA receptor expression and function in the normal adult rat prefrontal cortex, but fails to improve working memory and reverse MK801-induced working memory impairment. 2015 Nov 1
174 26390657 [Molecular mechanism of emodin on inhibiting autophagy induced by HBSS in renal tubular cells]. 2015 May 1
175 26622487 Rapamycin-induced autophagy activity promotes bone fracture healing in rats. 2015 Oct 2
176 26681922 Inhibition of mTOR Pathway by Rapamycin Reduces Brain Damage in Rats Subjected to Transient Forebrain Ischemia. 2015 3
177 24375611 Simvastatin promotes cardiac microvascular endothelial cells proliferation, migration and survival by phosphorylation of p70 S6K and FoxO3a. 2014 May 3
178 24404143 Rapamycin ameliorates inflammation and fibrosis in the early phase of cirrhotic portal hypertension in rats through inhibition of mTORC1 but not mTORC2. 2014 2
179 24510654 Rapamycin prevents N-methyl-D-aspartate-induced retinal damage through an ERK-dependent mechanism in rats. 2014 Jun 1
180 24586612 Periadventitial application of rapamycin-loaded nanoparticles produces sustained inhibition of vascular restenosis. 2014 1
181 24602288 Inhibition of mammalian target of rapamycin improves neurobehavioral deficit and modulates immune response after intracerebral hemorrhage in rat. 2014 Mar 6 1
182 24603476 Rapamycin slows IgA nephropathy progression in the rat. 2014 2
183 24619883 PPARγ activation attenuates glucose intolerance induced by mTOR inhibition with rapamycin in rats. 2014 May 1 2
184 24695395 Leptin induces cardiac fibrosis through galectin-3, mTOR and oxidative stress: potential role in obesity. 2014 May 1
185 24829408 mTOR signaling inhibition modulates macrophage/microglia-mediated neuroinflammation and secondary injury via regulatory T cells after focal ischemia. 2014 Jun 15 1
186 24889758 The mTOR signaling pathway and neuronal stem/progenitor cell proliferation in the hippocampus are altered during the development of absence epilepsy in a genetic animal model. 2014 Nov 2
187 24901414 Differential effects of antidepressant drugs on mTOR signalling in rat hippocampal neurons. 2014 Nov 1
188 24917666 Rapamycin and interleukin-1β impair brain-derived neurotrophic factor-dependent neuron survival by modulating autophagy. 2014 Jul 25 3
189 24976516 mTOR pathway is involved in ADP-evoked astrocyte activation and ATP release in the spinal dorsal horn in a rat neuropathic pain model. 2014 Sep 5 1
190 25256739 Blockade of mTOR signaling via rapamycin combined with immunotherapy augments antiglioma cytotoxic and memory T-cell functions. 2014 Dec 1
191 22684415 Rapamycin inhibits the mTOR/p70S6K pathway and attenuates cardiac fibrosis in adriamycin-induced dilated cardiomyopathy. 2013 Apr 2
192 23092918 mTOR inhibition modulates epileptogenesis, seizures and depressive behavior in a genetic rat model of absence epilepsy. 2013 Jun 1
193 23229928 Sirolimus reduces vasculopathy but exacerbates proteinuria in association with inhibition of VEGF and VEGFR in a rat kidney model of chronic allograft dysfunction. 2013 Feb 1
194 23239524 mTOR regulates fatty infiltration through SREBP-1 and PPARγ after a combined massive rotator cuff tear and suprascapular nerve injury in rats. 2013 May 2
195 23265586 Enhanced expression of glucose transporter-1 in vascular smooth muscle cells via the Akt/tuberous sclerosis complex subunit 2 (TSC2)/mammalian target of rapamycin (mTOR)/ribosomal S6 protein kinase (S6K) pathway in experimental renal failure. 2013 Feb 1
196 23313213 Rapamycin attenuates bladder hypertrophy during long-term outlet obstruction in vivo: tissue, matrix and mechanistic insights. 2013 Jun 1
197 23334408 CL316,243, a selective β3-adrenoceptor agonist, activates protein translation through mTOR/p70S6K signaling pathway in rat skeletal muscle cells. 2013 Apr 1
198 23466691 mTOR activation is required for the anti-alcohol effect of ketamine, but not memantine, in alcohol-preferring rats. 2013 Jun 15 2
199 23470622 Rapamycin reverses pulmonary artery smooth muscle cell proliferation in pulmonary hypertension. 2013 May 1
200 23566837 Rapamycin preserves the follicle pool reserve and prolongs the ovarian lifespan of female rats via modulating mTOR activation and sirtuin expression. 2013 Jul 1 2