Sirolimus

mechanistic target of rapamycin kinase ; Rattus norvegicus







284 Article(s)
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101 29675586 Rapamycin Alleviates Hormone Imbalance-Induced Chronic Nonbacterial Inflammation in Rat Prostate Through Activating Autophagy via the mTOR/ULK1/ATG13 Signaling Pathway. 2018 Aug 2
102 29757673 Rapamycin-insensitive mechanistic target of rapamycin regulates basal and resistance exercise-induced muscle protein synthesis. 2018 May 14 1
103 29803175 Echinacoside alleviated LPS-induced cell apoptosis and inflammation in rat intestine epithelial cells by inhibiting the mTOR/STAT3 pathway. 2018 Aug 1
104 29893708 Rapamycin Combi with TAE on the Growth, Metastasis, and Prognosis of Hepatocellular Carcinoma in Rat Models. 2018 July - August , 1
105 29904395 Rapamycin provides anti-epileptogenic effect in a rat model of post-traumatic epilepsy via deactivation of mTOR signaling pathway. 2018 Jun 1
106 29928901 Rapamycin mediates mTOR signaling in reactive astrocytes and reduces retinal ganglion cell loss. 2018 Nov 1
107 29996117 Blocking Mammalian Target of Rapamycin (mTOR) Alleviates Neuropathic Pain Induced by Chemotherapeutic Bortezomib. 2018 1
108 30050390 Inhibition of the mTOR Pathway Exerts Cardioprotective Effects Partly through Autophagy in CLP Rats. 2018 1
109 30132043 PCB 95 promotes dendritic growth in primary rat hippocampal neurons via mTOR-dependent mechanisms. 2018 Oct 1
110 30200803 The protective effects of rapamycin on cell autophagy in the renal tissues of rats with diabetic nephropathy via mTOR-S6K1-LC3II signaling pathway. 2018 Nov 2
111 30224017 Rapamycin Supplementation May Ameliorate Erectile Function in Rats With Streptozotocin-Induced Type 1 Diabetes by Inducing Autophagy and Inhibiting Apoptosis, Endothelial Dysfunction, and Corporal Fibrosis. 2018 Sep 3
112 30257237 Pim1 Overexpression Prevents Apoptosis in Cardiomyocytes After Exposure to Hypoxia and Oxidative Stress via Upregulating Cell Autophagy. 2018 1
113 30346929 Autophagy of macrophages is regulated by PI3k/Akt/mTOR signalling in the development of diabetic encephalopathy. 2018 Oct 22 1
114 30584274 Curcumin alleviates rheumatoid arthritis-induced inflammation and synovial hyperplasia by targeting mTOR pathway in rats. 2018 1
115 26588882 mTOR inhibition by rapamycin protects against deltamethrin-induced apoptosis in PC12 Cells. 2017 Jan 1
116 27660271 Neuroprotection Through Rapamycin-Induced Activation of Autophagy and PI3K/Akt1/mTOR/CREB Signaling Against Amyloid-β-Induced Oxidative Stress, Synaptic/Neurotransmission Dysfunction, and Neurodegeneration in Adult Rats. 2017 Oct 1
117 27888418 Suppression of mTOR signaling pathway promotes bone marrow mesenchymal stem cells differentiation into osteoblast in degenerative scoliosis: in vivo and in vitro. 2017 Feb 1
118 28108221 Sirtuin 1 independent effects of resveratrol in INS-1E β-cells. 2017 Feb 25 1
119 28199961 Proteomic analysis of laser capture microdissected focal lesions in a rat model of progenitor marker-positive hepatocellular carcinoma. 2017 Apr 18 2
120 28229367 Inhibition of mTOR Pathway by Rapamycin Decreases P-glycoprotein Expression and Spontaneous Seizures in Pharmacoresistant Epilepsy. 2017 Apr 2
121 28404768 DJ-1 overexpression restores ischaemic post-conditioning-mediated cardioprotection in diabetic rats: role of autophagy. 2017 Jun 1 1
122 28475806 Rapamycin reduced pulmonary vascular remodelling by inhibiting cell proliferation via Akt/mTOR signalling pathway down-regulation in the carotid artery-jugular vein shunt pulmonary hypertension rat model. 2017 Aug 1 2
123 28625574 Rapamycin decreased blood-brain barrier permeability in control but not in diabetic rats in early cerebral ischemia. 2017 Jul 27 1
124 28656223 Rapamycin inhibits CaCl2-induced thoracic aortic aneurysm formation in rats through mTOR-mediated suppression of proinflammatory mediators. 2017 Aug 4
125 28669853 Effect of sirolimus on arteriosclerosis induced by advanced glycation end products via inhibition of the ILK/mTOR pathway in kidney transplantation recipients. 2017 Oct 15 1
126 28729914 Effects of mTOR on Neurological Deficits after Transient Global Ischemia. 2017 1
127 28765938 Rapamycin inhibits spermatogenesis by changing the autophagy status through suppressing mechanistic target of rapamycin-p70S6 kinase in male rats. 2017 Oct 1
128 28801605 Luteolin, a natural flavonoid, inhibits methylglyoxal induced apoptosis via the mTOR/4E-BP1 signaling pathway. 2017 Aug 11 1
129 28808420 Inhibition of mTOR signaling Confers Protection against Cerebral Ischemic Injury in Acute Hyperglycemic Rats. 2017 2
130 29085189 Pharmacological inhibition of cannabinoid receptor 1 stimulates gastric release of nesfatin-1 via the mTOR pathway. 2017 Sep 21 1
131 29224002 The Protective Effects of Κ-Opioid Receptor Stimulation in Hypoxic Pulmonary Hypertension Involve Inhibition of Autophagy Through the AMPK-MTOR Pathway. 2017 1
132 29240812 Effects of vaspin on pancreatic β cell secretion via PI3K/Akt and NF-κB signaling pathways. 2017 1
133 26374551 Activation of mTOR signaling mediates the increased expression of AChE in high glucose condition: in vitro and in vivo evidences. 2016 Sep 1
134 26463951 PAR-1, -4, and the mTOR Pathway Following Germinal Matrix Hemorrhage. 2016 1
135 26566757 Blocking mammalian target of rapamycin alleviates bone cancer pain and morphine tolerance via µ-opioid receptor. 2016 Apr 15 1
136 26648565 Knockdown of NogoA prevents MPP+‑induced neurotoxicity in PC12 cells via the mTOR/STAT3 signaling pathway. 2016 Feb 1
137 26691904 Blood-brain barrier leakage after status epilepticus in rapamycin-treated rats I: Magnetic resonance imaging. 2016 Jan 1
138 26734934 Rapamycin Attenuates Splenomegaly in both Intrahepatic and Prehepatic Portal Hypertensive Rats by Blocking mTOR Signaling Pathway. 2016 2
139 26825372 DNA damage-inducible transcript 4 (DDIT4) mediates methamphetamine-induced autophagy and apoptosis through mTOR signaling pathway in cardiomyocytes. 2016 Mar 15 1
140 26946108 Intrathecal administration of rapamycin inhibits the phosphorylation of DRG Nav1.8 and attenuates STZ-induced painful diabetic neuropathy in rats. 2016 Apr 21 1
141 27111854 Autophagy Is Involved in the Sevoflurane Anesthesia-Induced Cognitive Dysfunction of Aged Rats. 2016 1
142 27113190 [Effect of rapamycin on proliferation of rat heart valve interstitial cells in vitro]. 2016 Apr 1
143 27217700 Contribution of mammalian target of rapamycin in the pathophysiology of cirrhotic cardiomyopathy. 2016 May 21 2
144 27235551 mTOR remains unchanged in diet-resistant (DR) rats despite impaired LKB1/AMPK cascade in adipose tissue. 2016 Aug 5 1
145 27239444 mTOR inhibition by rapamycin increases ceramide synthesis by promoting transforming growth factor-β1/Smad signaling in the skin. 2016 Apr 1
146 27261605 Saikosaponin a functions as anti-epileptic effect in pentylenetetrazol induced rats through inhibiting mTOR signaling pathway. 2016 Jul 1
147 27343825 Valproic acid exposure sequentially activates Wnt and mTOR pathways in rats. 2016 Sep 1
148 27371338 Protective effects of PF-4708671 against N-methyl-d-aspartic acid-induced retinal damage in rats. 2016 Dec 1
149 27423593 Inhibition of mammalian target of rapamycin attenuates early brain injury through modulating microglial polarization after experimental subarachnoid hemorrhage in rats. 2016 Aug 15 3
150 27489506 Rapamycin Reduced Ischemic Brain Damage in Diabetic Animals Is Associated with Suppressions of mTOR and ERK1/2 Signaling. 2016 3