Sirolimus

mechanistic target of rapamycin kinase ; Rattus norvegicus







284 Article(s)
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51 31782272 Roles of the mammalian target of rapamycin (mTOR) signaling pathway in the repair of hyperoxia-induced acute lung injury. 2020 Jan 2
52 32006902 Ginsenoside Rb1 attenuates cardiomyocyte apoptosis induced by myocardial ischemia reperfusion injury through mTOR signal pathway. 2020 May 1
53 32104252 Dl-3n-butylphthalide improves spatial learning and memory in rats with vascular dementia by reducing autophagy via regulation of the mTOR signaling pathway. 2020 Mar 1
54 32182210 Rapamycin protects chondrocytes against IL-18-induced apoptosis and ameliorates rat osteoarthritis. 2020 Mar 17 1
55 32395516 Reduction of FoxP3+ Tregs by an immunosuppressive protocol of rapamycin plus Thymalfasin and Huaier extract predicts positive survival benefits in a rat model of hepatocellular carcinoma. 2020 Apr 1
56 32399023 Effect of Electroacupuncture Treatment at Dazhui (GV14) and Mingmen (GV4) Modulates the PI3K/AKT/mTOR Signaling Pathway in Rats after Spinal Cord Injury. 2020 3
57 32444657 Enhanced skeletal muscle insulin sensitivity after acute resistance-type exercise is upregulated by rapamycin-sensitive mTOR complex 1 inhibition. 2020 May 22 1
58 32462682 The role of mTOR and oral intervention of combined Zingiber officinale-Terminalia chebula extract in type 2 diabetes rat models. 2020 Jul 1
59 32512114 mTOR activation by constitutively active serotonin6 receptors as new paradigm in neuropathic pain and its treatment. 2020 Oct 1
60 32570711 Parathyroid Cell Proliferation in Secondary Hyperparathyroidism of Chronic Kidney Disease. 2020 Jun 18 1
61 32642911 Rapamycin Alleviates Hypertriglyceridemia-Related Acute Pancreatitis via Restoring Autophagy Flux and Inhibiting Endoplasmic Reticulum Stress. 2020 Aug 1
62 32645638 Effect of rapamycin on repeated immobilization stress-induced immune alterations in the rat spleen. 2020 Jun 25 2
63 32651677 Altered expression of activator proteins that control follicle reserve after ovarian tissue cryopreservation/transplantation and primordial follicle loss prevention by rapamycin. 2020 Sep 1
64 32712090 Effect of lycopene on pain facilitation and the SIRT1/mTOR pathway in the dorsal horn of burn injury rats. 2020 Dec 15 1
65 32774416 Shenzhiling Oral Liquid Protects STZ-Injured Oligodendrocyte through PI3K/Akt-mTOR Pathway. 2020 2
66 32798557 Rapamycin improves renal injury induced by Iodixanol in diabetic rats by deactivating the mTOR/p70S6K signaling pathway. 2020 Oct 15 4
67 32802135 Zishen Huoxue Recipe Protecting Mitochondrial Function of Hypoxic/Reoxygenated Myocardial Cells through mTORC1 Signaling Pathway. 2020 1
68 32949703 Tetrahydropalmatine protects against acute lung injury induced by limb ischemia/reperfusion through restoring PI3K/AKT/mTOR-mediated autophagy in rats. 2020 Oct 1
69 33075479 Acute exercise enhances fear extinction through a mechanism involving central mTOR signaling. 2020 Dec 2
70 33130049 The interrupted cross-talk of inflammatory and oxidative stress trajectories signifies the effect of artesunate against hepatic ischemia/reperfusion-induced inflammasomopathy. 2020 Dec 15 1
71 33312358 β-ecdysterone alleviates osteoarthritis by activating autophagy in chondrocytes through regulating PI3K/AKT/mTOR signal pathway. 2020 1
72 33317171 Pharmacological Inhibition of O-GlcNAc Transferase Promotes mTOR-Dependent Autophagy in Rat Cortical Neurons. 2020 Dec 9 2
73 29869197 Cannabidiol Induces Rapid and Sustained Antidepressant-Like Effects Through Increased BDNF Signaling and Synaptogenesis in the Prefrontal Cortex. 2019 Feb 1
74 29962282 Rapamycin inhibits activation of AMPK-mTOR signaling pathway-induced Alzheimer's disease lesion in hippocampus of rats with type 2 diabetes mellitus. 2019 Feb 5
75 30032425 Pain-Relieving Effects of mTOR Inhibitor in the Anterior Cingulate Cortex of Neuropathic Rats. 2019 Apr 2
76 30325723 Rapamycin alleviates proinflammatory cytokines and nociceptive behavior induced by chemotherapeutic paclitaxel. 2019 Jan 2
77 30447474 DINP aggravates autoimmune thyroid disease through activation of the Akt/mTOR pathway and suppression of autophagy in Wistar rats. 2019 Feb 1
78 30474386 Employing the Sirolimus-Eluting Poly (Propylene Carbonate) Mesh for the Prevention of Arteriovenous Graft Stenosis in Rats. 2019 May 1
79 30553049 Rapamycin administration during normal and diabetic pregnancy effects the mTOR and angiogenesis signaling in the rat placenta. 2019 Mar 1
80 30628698 Galangin decreases p‑tau, Aβ42 and β‑secretase levels, and suppresses autophagy in okadaic acid‑induced PC12 cells via an Akt/GSK3β/mTOR signaling‑dependent mechanism. 2019 Mar 1
81 30684510 18F-FDG positron emission tomography as a novel diagnostic tool for peripheral nerve injury. 2019 Apr 1 1
82 30838711 Ganoderic acid A alleviates hypoxia-induced apoptosis, autophagy, and inflammation in rat neural stem cells through the PI3K/AKT/mTOR pathways. 2019 May 1
83 30953772 Behavioral conditioning of anti-proliferative and immunosuppressive properties of the mTOR inhibitor rapamycin. 2019 Jul 1
84 31057050 The protective effect and mechanism of rapamycin in the rat model of IgA nephropathy. 2019 Nov 2
85 31152486 Inhibition of the mTOR pathway: A new mechanism of β cell toxicity induced by tacrolimus. 2019 Dec 2
86 31257459 17β‑Estradiol protects against interleukin‑1β‑induced apoptosis in rat nucleus pulposus cells via the mTOR/caspase‑3 pathway. 2019 Aug 1
87 31505123 Modulation of oxidative-nitrosative stress and inflammatory response by rapamycin in target and distant organs in rats exposed to hindlimb ischemia-reperfusion: the role of mammalian target of rapamycin. 2019 Dec 2
88 31517703 Relationship Between mTOR Signaling Activation and Postoperative Neurocognitive Disorder in Aged Rats. 2019 Sep 2
89 31534118 Exosomes derived from cardiac progenitor cells attenuate CVB3-induced apoptosis via abrogating the proliferation of CVB3 and modulating the mTOR signaling pathways. 2019 Sep 18 1
90 31553625 Perinatal nicotine exposure alters Akt/GSK-3β/mTOR/autophagy signaling, leading to development of hypoxic-ischemic-sensitive phenotype in rat neonatal brain. 2019 Dec 1 1
91 31564412 Prevention of post-ischemic seizure by rapamycin is associated with deactivation of mTOR and ERK1/2 pathways in hyperglycemic rats. 2019 Nov 26 5
92 31591945 Regulatory role of hippocampal PI3K and mTOR signaling pathway in NMDA-induced infant spasm rats. 2019 Dec 2
93 31638215 Kaempferol promotes bone formation in part via the mTOR signaling pathway. 2019 Dec 1
94 31849609 Neuroligin 3 Regulates Dendritic Outgrowth by Modulating Akt/mTOR Signaling. 2019 1
95 32042772 Catalpol induces cell activity to promote axonal regeneration via the PI3K/AKT/mTOR pathway in vivo and in vitro stroke model. 2019 Dec 5
96 27133527 5-HT 2 receptor mediates high-fat diet-induced hepatic steatosis and very low density lipoprotein overproduction in rats. 2018 Jan - Feb 1
97 29277549 The mTOR promotes oxidative stress-induced apoptosis of mesangial cells in diabetic nephropathy. 2018 Sep 15 2
98 29444470 Effect of sirolimus on liver cirrhosis and hepatic encephalopathy of common bile duct-ligated rats. 2018 Apr 5 1
99 29468175 Rapamycin prevents cerebral stroke by modulating apoptosis and autophagy in penumbra in rats. 2018 Feb 3
100 29540670 Decreased autophagy induced by β1-adrenoceptor autoantibodies contributes to cardiomyocyte apoptosis. 2018 Mar 14 1