Sirolimus

mechanistic target of rapamycin kinase ; Rattus norvegicus







284 Article(s)
Download
PMID
Title
Pub. Year
#Total Relationships
1 34784444 mTOR-mediated autophagy in the hippocampus is involved in perioperative neurocognitive disorders in diabetic rats. 2022 Apr 2
2 34840266 Pharmacological Inhibition of Mammalian Target of Rapamycin Attenuates Deoxycorticosterone Acetate Salt-Induced Hypertension and Related Pathophysiology: Regulation of Oxidative Stress, Inflammation, and Cardiovascular Hypertrophy in Male Rats. 2022 Mar 1 1
3 34854520 MiRNA-339-5p promotes isoproterenol-induced cardiomyocyte hypertrophy by targeting VCP to activate the mTOR signaling. 2022 Feb 1
4 34874016 mTOR inhibitor improves testosterone-induced myocardial hypertrophy in hypertensive rats. 2022 Jan 31 1
5 35048147 Sub-Flap Use of Nano-Selenium Oxide Solution Enhances Skin Flap Viability in Rats: Study the Novel Role of mTOR and p-mTOR Expression. 2022 Jan 20 1
6 35133561 MiRNA-122-5p inhibitor abolishes angiotensin II-mediated loss of autophagy and promotion of apoptosis in rat cardiofibroblasts by modulation of the apelin-AMPK-mTOR signaling. 2022 Feb 1
7 35196893 Interleukin-10 regulates starvation-induced autophagy through the STAT3-mTOR-p70s6k axis in hepatic stellate cells. 2022 May 2
8 35197970 Rapamycin Attenuated Zinc-Induced Tau Phosphorylation and Oxidative Stress in Rats: Involvement of Dual mTOR/p70S6K and Nrf2/HO-1 Pathways. 2022 4
9 35438806 Poly(I:C) attenuates myocardial ischemia/reperfusion injury by restoring autophagic function. 2022 May 3
10 35446876 The mTOR inhibitor Rapamycin protects from premature cellular senescence early after experimental kidney transplantation. 2022 3
11 35587661 [Mechanism of microRNA-100-5p on mammalian target of rapamycin in temporomandibular arthritis]. 2022 Feb 1
12 35623563 Synthetic high-density lipoprotein nanoparticles delivering rapamycin for the treatment of age-related macular degeneration. 2022 May 24 1
13 32378972 mTOR/NF-κB signaling pathway protects hippocampal neurons from injury induced by intermittent hypoxia in rats. 2021 Oct 5
14 33278393 Effects of prolonged cold-ischemia on autophagy in the graft lung in a rat orthotopic lung transplantation model. 2021 Mar 1 1
15 33278579 Simvastatin accelerates the healing process of burn wound in Wistar rats through Akt/mTOR signaling pathway. 2021 Jul 1
16 33285202 Neurobehavioral effects in rats with experimentally induced glioblastoma after treatment with the mTOR-inhibitor rapamycin. 2021 Feb 15 2
17 33383488 Rapamycin alleviates cognitive impairment in murine vascular dementia: The enhancement of mitophagy by PI3K/AKT/mTOR axis. 2021 Apr 2
18 33479328 Hyperglycemia-induced VEGF and ROS production in retinal cells is inhibited by the mTOR inhibitor, rapamycin. 2021 Jan 21 2
19 33530801 1,25-(OH)2D3 ameliorates renal interstitial fibrosis in UUO rats through the AMPKα/mTOR pathway. 2021 Feb 1
20 33598769 Taurine ameliorates axonal damage in sciatic nerve of diabetic rats and high glucose exposed DRG neuron by PI3K/Akt/mTOR-dependent pathway. 2021 Mar 1
21 33641344 mTOR inhibition as a possible pharmacological target in the management of systemic inflammatory response and associated neuroinflammation by lipopolysaccharide challenge in rats. 2021 Sep 1
22 33897438 Disrupting Reconsolidation by Systemic Inhibition of mTOR Kinase via Rapamycin Reduces Cocaine-Seeking Behavior. 2021 1
23 33930202 Rapamycin attenuates depression and anxiety-like behaviors through modulation of the NLRP3 pathway in pentylenetetrazole-kindled male Wistar rats. 2021 Dec 1
24 33988537 LBP Protects Hepatocyte Mitochondrial Function Via the PPAR-CYP4A2 Signaling Pathway in a Rat Sepsis Model. 2021 Dec 1 1
25 34021461 Indoleamine 2,3-Dioxygenase 1 (IDO1) Promotes Cardiac Hypertrophy via a PI3K-AKT-mTOR-Dependent Mechanism. 2021 Aug 1
26 34064854 Autophagy and Mitophagy Promotion in a Rat Model of Endometriosis. 2021 May 11 1
27 34074073 [Rapamycin activates autophagy by inhibiting mTOR pathway to alleviate early osteoporosis in rats with skeletal fluorosis]. 2021 May 20 3
28 34082015 Shenzhiling oral liquid protects the myelin sheath against Alzheimer's disease through the PI3K/Akt-mTOR pathway. 2021 Oct 5 1
29 34102263 Rapamycin Accelerates Axon Regeneration Through Schwann Cell-mediated Autophagy Following Inferior Alveolar Nerve Transection in Rats. 2021 Aug 1 1
30 34167449 Icariin alleviates osteoarthritis by regulating autophagy of chondrocytes by mediating PI3K/AKT/mTOR signaling. 2021 Dec 3
31 34177589 Chaihu Guizhi Ganjiang Decoction Ameliorates Pancreatic Fibrosis via JNK/mTOR Signaling Pathway. 2021 1
32 34222263 IRE1-mTOR-PERK Axis Coordinates Autophagy and ER Stress-Apoptosis Induced by P2X7-Mediated Ca2+ Influx in Osteoarthritis. 2021 1
33 34242720 The effects of mTOR or Vps34-mediated autophagy on methylmercury-induced neuronal apoptosis in rat cerebral cortex. 2021 Sep 2
34 34278477 Asiaticoside reduces autophagy and improves memory in a rat model of dementia through mTOR signaling pathway regulation. 2021 Sep 1
35 34322484 Mechanical Overloading Induced-Activation of mTOR Signaling in Tendon Stem/Progenitor Cells Contributes to Tendinopathy Development. 2021 2
36 34354602 Rapalink-1 Increased Infarct Size in Early Cerebral Ischemia-Reperfusion With Increased Blood-Brain Barrier Disruption. 2021 1
37 34362635 Leucine induces cardioprotection in vitro by promoting mitochondrial function via mTOR and Opa-1 signaling. 2021 Sep 22 1
38 34374900 Antidepressant-like Effect of 3-n-Butylphthalide in Rats Exposed to Chronic Unpredictable Mild Stress: Modulation of Brain-Derived Neurotrophic Factor Level and mTOR Activation in Cortex. 2021 Nov 1
39 34417329 PI3Kγ/AKT Signaling in High Molecular Weight Hyaluronan (HMWH)-Induced Anti-Hyperalgesia and Reversal of Nociceptor Sensitization. 2021 Oct 6 1
40 34494222 Insulin growth factor-1 enhances proliferation and inhibits apoptosis of neural progenitor cells by phosphorylation of Akt/mTOR/p70S6K molecules and triggering intrinsic apoptosis signaling pathway. 2021 Sep 7 1
41 34533799 Mechanism of curcumin against myocardial ischaemia-reperfusion injury based on the P13K/Akt/mTOR signalling pathway. 2021 Sep 1
42 34555398 Cardio-protective effect of tetrahydrocurcumin, the primary hydrogenated metabolite of curcumin in vivo and in vitro: Induction of apoptosis and autophagy via PI3K/AKT/mTOR pathways. 2021 Nov 15 1
43 34698133 Amelioration of Diabetic Nephropathy by Targeting Autophagy via Rapamycin or Fasting: Relation to Cell Apoptosis/Survival. 2021 Oct 22 1
44 34812711 Effect of Sertoli Cell Transplant and Rapamycin Pretreatment on Middle Cerebral Artery Occlusion-Induced Brain Ischemia in a Rat Model. 2021 Nov 2
45 34859624 Effect of 17β-estradiol on the proliferation of condylar chondrocytes. 2021 Dec 1 1
46 34863087 Fyn kinase regulates dopaminergic neuronal apoptosis in animal and cell models of high glucose (HG) treatment. 2021 Dec 4 1
47 31423743 Corticosterone induces neurotoxicity in PC12 cells via disrupting autophagy flux mediated by AMPK/mTOR signaling. 2020 Feb 1
48 31664701 Iron Overload Impairs Autophagy: Effects of Rapamycin in Ameliorating Iron-Related Memory Deficits. 2020 Feb 2
49 31693798 mTOR drives cerebrovascular, synaptic, and cognitive dysfunction in normative aging. 2020 Jan 1
50 31746373 Rapamycin regulates the balance between cardiomyocyte apoptosis and autophagy in chronic heart failure by inhibiting mTOR signaling. 2020 Jan 5