Sunitinib

kinase insert domain receptor ; Homo sapiens







166 Article(s)
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Title
Pub. Year
#Total Relationships
51 25458015 Sunitinib impedes brain tumor progression and reduces tumor-induced neurodegeneration in the microenvironment. 2015 Feb 4
52 25639617 Refractory angiosarcoma of the breast with VEGFR2 upregulation successfully treated with sunitinib. 2015 Mar-Apr 1
53 25907705 Axitinib in metastatic renal cell carcinoma. 2015 May 1
54 26042424 The VEGF-Receptor Inhibitor Axitinib Impairs Dendritic Cell Phenotype and Function. 2015 2
55 26067856 Tyrosine Kinase Inhibitors as Potential Therapeutic Agents in the Treatment of Granulosa Cell Tumors of the Ovary. 2015 Sep 1
56 26380584 Decreased efficacy of drugs targeting the vascular endothelial growth factor pathway by the epigenetic silencing of FLT1 in renal cancer cells. 2015 1
57 26408725 Sunitinib Malate plus Lomustine for Patients with Temozolomide-refractory Recurrent Anaplastic or Low-grade Glioma. 2015 Oct 1
58 26484875 Inhibition of epithelial growth factor receptor can play an important role in reducing cell growth and survival in adrenocortical tumors. 2015 Dec 15 2
59 24127298 Risk of gastrointestinal events with sorafenib, sunitinib and pazopanib in patients with solid tumors: a systematic review and meta-analysis of clinical trials. 2014 Aug 15 2
60 24185817 Sunitinib--CLIO conjugate: a VEGFR/PDGFR-targeting active MR probe. 2014 Jun 4
61 24704536 The role of angiopoietins as potential therapeutic targets in renal cell carcinoma. 2014 Apr 1
62 24723451 Culture dimensionality influences the resistance of glioblastoma stem-like cells to multikinase inhibitors. 2014 Jun 1
63 24743196 [Renal cell carcinoma]. 2014 Feb 1
64 24756791 Sunitinib in the treatment of advanced solid tumors. 2014 2
65 24783183 Bowel perforation associated sunitinib therapy for recurred gastric gastrointestinal stromal tumor. 2014 Apr 2
66 24786599 Active angiogenesis in metastatic renal cell carcinoma predicts clinical benefit to sunitinib-based therapy. 2014 May 27 1
67 24842548 Dual VEGF/VEGFR inhibition in advanced solid malignancies: clinical effects and pharmacodynamic biomarkers. 2014 Aug 2
68 24927771 Risk of thyroid dysfunction in patients with solid tumors treated with VEGF receptor tyrosine kinase inhibitors: a critical literature review and meta analysis. 2014 Sep 1
69 25058995 Experience with sunitinib treatment for metastatic renal cell carcinoma in a large cohort of Israeli patients: outcome and associated factors. 2014 Jun 1
70 25076341 Targeted agents in treatment of neuroendocrine tumors of pancreas. 2014 Jul 28 2
71 25085632 Next generation sequencing analysis of platinum refractory advanced germ cell tumor sensitive to Sunitinib (Sutent®) a VEGFR2/PDGFRβ/c-kit/ FLT3/RET/CSF1R inhibitor in a phase II trial. 2014 Aug 1 6
72 25151214 Alternative dosing schedules for sunitinib as a treatment of patients with metastatic renal cell carcinoma. 2014 Dec 2
73 25228815 Antiangiogenic cancer drug sunitinib exhibits unexpected proangiogenic effects on endothelial cells. 2014 3
74 25299731 Unbinding pathways of VEGFR2 inhibitors revealed by steered molecular dynamics. 2014 Nov 24 1
75 25336977 Risk of treatment-related deaths with vascular endothelial growth factor receptor tyrosine kinase inhibitors: a meta-analysis of 41 randomized controlled trials. 2014 1
76 25353068 VEGF₁₂₁-conjugated mesoporous silica nanoparticle: a tumor targeted drug delivery system. 2014 Dec 10 1
77 21478036 Expression level of vascular endothelial growth factor receptor-2 in radical nephrectomy specimens as a prognostic predictor in patients with metastatic renal cell carcinoma treated with sunitinib. 2013 May 3
78 23322198 Cox-2 inhibition enhances the activity of sunitinib in human renal cell carcinoma xenografts. 2013 Feb 5 2
79 23336010 Trisubstituted pyrazolopyrimidines as novel angiogenesis inhibitors. 2013 1
80 23398161 Tyrosine kinase inhibitor-induced thyroid disorders: a review and hypothesis. 2013 Feb 2
81 23399884 Synthesis of 5-(ethylsulfonyl)-2-methoxyaniline: An important pharmacological fragment of VEGFR2 and other inhibitors. 2013 1
82 23475388 Expression of vascular endothelial growth factor (VEGF) and its receptors VEGFR1 and VEGFR2 in primary and recurrent WHO grade III meningiomas. 2013 Sep 1
83 23492365 Inhibition of histone demethylase JMJD1A improves anti-angiogenic therapy and reduces tumor-associated macrophages. 2013 May 15 2
84 23507600 [A case of male breast cancer for which mTOR inhibitor was effective with advanced renal cancer]. 2013 Mar 1
85 23511629 VEGF and VEGFR polymorphisms affect clinical outcome in advanced renal cell carcinoma patients receiving first-line sunitinib. 2013 Mar 19 1
86 23601669 The progression free survival-plateau with vascular endothelial growth factor receptor inhibitors--is there more to come? 2013 Jul 2
87 23626551 Targeting VEGF-VEGFR Pathway by Sunitinib in Peripheral Primitive Neuroectodermal Tumor, Paraganglioma and Epithelioid Hemangioendothelioma: Three Case Reports. 2013 Jan 1
88 23969186 Antiproliferative and proapoptotic activity of sunitinib on endothelial and anaplastic thyroid cancer cells via inhibition of Akt and ERK1/2 phosphorylation and by down-regulation of cyclin-D1. 2013 Sep 1
89 24061866 Differential regulation of sunitinib targets predicts its tumor-type-specific effect on endothelial and/or tumor cell apoptosis. 2013 Dec 1
90 24123039 Effects of single nucleotide polymorphisms on treatment outcomes and toxicity in patients treated with sunitinib. 2013 Oct 2
91 24640739 [VEGFRs in neoplastic angiogenesis and prospects for therapy of brain tumors]. 2013 1
92 21445974 Inhibition of activated receptor tyrosine kinases by Sunitinib induces growth arrest and sensitizes melanoma cells to Bortezomib by blocking Akt pathway. 2012 Feb 15 1
93 21699503 Indolinones and anilinophthalazines differentially target VEGF-A- and basic fibroblast growth factor-mediated responses in primary human endothelial cells. 2012 Jan 2
94 21953673 Sunitinib-induced changes in circulating endothelial cell-related proteins in patients with metastatic renal cell cancer. 2012 Aug 15 1
95 22015552 Gastrointestinal stromal tumors. 2012 4
96 22207048 VEGF-A/VEGFR-2 signaling plays an important role for the motility of pancreas cancer cells. 2012 Aug 3
97 22237457 Efficacy and safety of vascular endothelial growth factor receptor tyrosine kinase inhibitors in patients with metastatic renal cell carcinoma and poor risk features. 2012 Apr 1
98 22289686 Sequential therapy with targeted agents in patients with advanced renal cell carcinoma: optimizing patient benefit. 2012 Dec 1
99 22317769 A phase II clinical trial of sunitinib following hepatic transarterial embolization for metastatic neuroendocrine tumors. 2012 Sep 2
100 22395469 Promoter methylation status of VEGF receptor genes: a possible epigenetic biomarker to anticipate the efficacy of intracellular-acting VEGF-targeted drugs in cancer cells. 2012 Feb 1