Sunitinib

kinase insert domain receptor ; Homo sapiens







166 Article(s)
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1 35290929 Exploration of novel VEGFR2 tyrosine kinase inhibitors via design and synthesis of new alkylated indolyl-triazole Schiff bases for targeting breast cancer. 2022 May 1
2 35313079 CRISPR-mediated knockout of VEGFR2/KDR inhibits cell growth in a squamous thyroid cancer cell line. 2022 May 1
3 35562342 DMDRMR promotes angiogenesis via antagonizing DAB2IP in clear cell renal cell carcinoma. 2022 May 13 1
4 33078449 Synthesis, biological evaluation, and in silico study of pyrazoline-conjugated 2,4-dimethyl-1H-pyrrole-3-carboxylic acid derivatives. 2021 Feb 1
5 33170322 An investigation into possible interactions among four vascular epidermal growth factor receptor-tyrosine kinase inhibitors with gefitinib. 2021 Jan 2
6 33309571 Bleeding with vascular endothelial growth factor tyrosine kinase inhibitor: A network meta-analysis. 2021 Jan 1
7 33455080 Dysregulation of the Sirt5/IDH2 axis contributes to sunitinib resistance in human renal cancer cells. 2021 Mar 4
8 33647840 Potential of substituted quinazolines to interact with multiple targets in the treatment of cancer. 2021 Apr 1 1
9 34243074 3-Alkenyl-2-oxindoles: Synthesis, antiproliferative and antiviral properties against SARS-CoV-2. 2021 Sep 1
10 34306023 Identification of MX2 as a Novel Prognostic Biomarker for Sunitinib Resistance in Clear Cell Renal Cell Carcinoma. 2021 2
11 34853223 Vascular Endothelial Growth Factor Receptor Inhibitors Impair Left Ventricular Diastolic Functions. 2021 1
12 34912710 Identification of a Novel Stem Cell Subtype for Clear Cell Renal Cell Carcinoma Based on Stem Cell Gene Profiling. 2021 2
13 32767163 Treating metastatic clear-cell renal cell carcinoma: beyond immunotherapy. 2020 Aug 7 1
14 32885522 Structure-activity relationship studies of indolin-2-one derivatives as vascular endothelial growth factor receptor inhibitors and anticancer agents. 2020 Dec 1
15 32923192 Sunitinib: An Unusual Cause of Pneumothorax in a Patient With Metastatic Chromophobe Renal Cell Carcinoma. 2020 Aug 6 2
16 32947227 Novel 2-indolinone thiazole hybrids as sunitinib analogues: Design, synthesis, and potent VEGFR-2 inhibition with potential anti-renal cancer activity. 2020 Dec 15 4
17 33038552 Discovery of novel indolyl-1,2,4-triazole hybrids as potent vascular endothelial growth factor receptor-2 (VEGFR-2) inhibitors with potential anti-renal cancer activity. 2020 Dec 1
18 30401688 Phase III Trial of Adjuvant Sunitinib in Patients with High-Risk Renal Cell Carcinoma: Exploratory Pharmacogenomic Analysis. 2019 Feb 15 2
19 30566287 Synthesis, Characterization and in vitro Studies of a Cathepsin B-Cleavable Prodrug of the VEGFR Inhibitor Sunitinib. 2019 Jan 2
20 30689282 Exploring binding mechanisms of VEGFR2 with three drugs lenvatinib, sorafenib, and sunitinib by molecular dynamics simulation and free energy calculation. 2019 May 3
21 30914797 The adjuvant treatment of kidney cancer: a multidisciplinary outlook. 2019 Jul 2
22 31054432 Exploration of N-alkyl-2-[(4-oxo-3-(4-sulfamoylphenyl)-3,4-dihydroquinazolin-2-yl)thio]acetamide derivatives as anticancer and radiosensitizing agents. 2019 Jul 1
23 31231785 Phase II trial of continuous treatment with sunitinib in patients with high-risk (BCG-refractory) non-muscle invasive bladder cancer. 2019 Dec 2
24 31297023 Synthesis, anticancer, apoptosis-inducing activities and EGFR and VEGFR2 assay mechanistic studies of 5,5-diphenylimidazolidine-2,4-dione derivatives: Molecular docking studies. 2019 Jul 1
25 29095068 Pro-angiogenic gene expression is associated with better outcome on sunitinib in metastatic clear-cell renal cell carcinoma. 2018 Apr 5
26 29289530 A Vascular Endothelial Growth Factor-Dependent Sprouting Angiogenesis Assay Based on an In Vitro Human Blood Vessel Model for the Study of Anti-Angiogenic Drugs. 2018 Jan 1
27 29554654 Radiotherapy and Vascular Endothelial Growth Factor Receptor-Tyrosine Kinase Inhibitors in Renal Cancer. 2018 Mar 19 1
28 29662541 Cabozantinib in the treatment of advanced renal cell carcinoma in adults following prior vascular endothelial growth factor targeted therapy: clinical trial evidence and experience. 2018 Mar 3
29 27030134 Intrinsic resistance to sunitinib in patients with metastatic renal cell carcinoma. 2017 Feb 3
30 28123542 Influence of VEGFR single nucleotide polymorphisms on the efficacy of sunitinib therapy against renal cell carcinoma. 2017 Jan 4
31 28276433 Renal cell carcinoma. 2017 Mar 9 1
32 28423517 Next generation sequencing of extraskeletal myxoid chondrosarcoma. 2017 Mar 28 1
33 28430711 Evaluation of KDR rs34231037 as a predictor of sunitinib efficacy in patients with metastatic renal cell carcinoma. 2017 Jun 2
34 28561780 Synthesis and Evaluation of Novel 2-Pyrrolidone-Fused (2-Oxoindolin-3-ylidene)methylpyrrole Derivatives as Potential Multi-Target Tyrosine Kinase Receptor Inhibitors. 2017 May 31 2
35 28954991 Antiangiogenic agent sunitinib induces epithelial to mesenchymal transition and accelerates motility of colorectal cancer cells. 2017 3
36 28978162 Effects of VEGF and VEGFR polymorphisms on the outcome of patients with metastatic renal cell carcinoma treated with sunitinib: a systematic review and meta-analysis. 2017 Sep 15 3
37 29086859 Structural optimization and evaluation of novel 2-pyrrolidone-fused (2-oxoindolin-3-ylidene)methylpyrrole derivatives as potential VEGFR-2/PDGFRβ inhibitors. 2017 Aug 1 1
38 26439451 Cardiovascular toxicity after antiangiogenic therapy in persons older than 65 years with advanced renal cell carcinoma. 2016 Jan 1 2
39 26597115 Molecular mechanism mediating cytotoxic activity of axitinib in sunitinib-resistant human renal cell carcinoma cells. 2016 Sep 2
40 27103123 Phase I study of safety and tolerability of sunitinib in combination with sirolimus in patients with refractory solid malignancies and determination of VEGF (VEGF-A) and soluble VEGF-R2 (sVEGFR2) in plasma. 2016 Jun 2
41 27109549 Phase II evaluation of sunitinib in the treatment of recurrent or refractory high-grade glioma or ependymoma in children: a children's Oncology Group Study ACNS1021. 2016 Jul 3
42 27149458 Recurrent Olfactory Neuroblastoma Treated With Cetuximab and Sunitinib: A Case Report. 2016 May 1
43 27164264 Tyrosine kinase inhibitor sunitinib therapy is effective in the treatment of bone metastasis from cancer of unknown primary: Identification of clinical and immunohistochemical biomarkers predicting survival. 2016 Sep 15 1
44 27175586 Angiogenesis genotyping in the selection of first-line treatment with either sunitinib or pazopanib for advanced renal cell carcinoma. 2016 Jun 21 1
45 27288242 The tyrosine kinase inhibitor, sunitinib malate, induces cognitive impairment in vivo via dysregulating VEGFR signaling, apoptotic and autophagic machineries. 2016 Sep 2
46 27822356 Efficacy of pazopanib and sunitinib in advanced axial chordoma: a single reference centre case series. 2016 1
47 30695560 [Sunitinib: 10 years after approval for the therapy of metastatic renal cell carcinoma]. 2016 2
48 24710685 Predictive role of tissue-based molecular markers in patients treated with sunitinib for metastatic renal cell carcinoma. 2015 Jan 2
49 25100872 Phase II trial of sunitinib for recurrent and progressive atypical and anaplastic meningioma. 2015 Jan 4
50 25422908 Effects of preset sequential administrations of sunitinib and everolimus on tumour differentiation in Caki-1 renal cell carcinoma. 2015 Jan 6 1