Simvastatin

mitogen-activated protein kinase 3 ; Homo sapiens







22 Article(s)
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1 31105786 Inhibitory effect of simvastatin in nasopharyngeal carcinoma cells. 2019 Jun 1
2 31452046 Anti-leukemic effects of simvastatin on NRASG12D mutant acute myeloid leukemia cells. 2019 Dec 1
3 28916945 Simvastatin enhances radiation sensitivity of colorectal cancer cells. 2018 Mar 1
4 29795329 Integration of Ca2+ signaling regulates the breast tumor cell response to simvastatin and doxorubicin. 2018 Sep 1
5 29916838 Simvastatin reverses multiple myeloma serum-induced prothrombotic phenotype in endothelial cells via ERK 1/2 signalling pathway. 2018 Sep 2
6 30513525 Simvastatin Protects Dopaminergic Neurons Against MPP+-Induced Oxidative Stress and Regulates the Endogenous Anti-Oxidant System Through ERK. 2018 5
7 30584296 The role of the ERK1/2 pathway in simvastatin-loaded nanomicelles and simvastatin in regulating the osteogenic effect in MG63 cells. 2018 4
8 28968609 Inhibition of Prenylation Promotes Caspase 3 Activation, Lamin B Degradation and Loss in Metabolic Cell Viability in Pancreatic β-Cells. 2017 1
9 26565813 Simvastatin-induced breast cancer cell death and deactivation of PI3K/Akt and MAPK/ERK signalling are reversed by metabolic products of the mevalonate pathway. 2016 Jan 19 2
10 26756263 The apoptotic effect of simvastatin via the upregulation of BIM in nonsmall cell lung cancer cells. 2016 2
11 26875818 Simvastatin and atorvastatin facilitates amyloid β-protein degradation in extracellular spaces by increasing neprilysin secretion from astrocytes through activation of MAPK/Erk1/2 pathways. 2016 Jun 2
12 27123120 Simvastatin blocks TGF-β1-induced epithelial-mesenchymal transition in human prostate cancer cells. 2016 May 1
13 27347133 Statin induces apoptosis of human colon cancer cells and downregulation of insulin-like growth factor 1 receptor via proapoptotic ERK activation. 2016 Jul 1
14 25432084 Effects of simvastatin on cell viability and proinflammatory pathways in lung adenocarcinoma cells exposed to hydrogen peroxide. 2014 Nov 29 2
15 23352311 Reduction of platelet cytosolic phospholipase A2 activity by atorvastatin and simvastatin: biochemical regulatory mechanisms. 2013 Apr 1
16 23558220 Decreased tissue levels of cyclophilin A, a cyclosporine a target and phospho-ERK1/2 in simvastatin patients with abdominal aortic aneurysm. 2013 Jun 3
17 24080182 Simvastatin increases Prolyl-4-Hydroxylase α1 expression in atherosclerotic plaque and ox-LDL-stimulated human aortic smooth muscle cells via p38 MAPK and ERK1/2 signaling. 2013 Dec 4
18 21052011 Simvastatin reduces lipoprotein-associated phospholipase A2 in lipopolysaccharide-stimulated human monocyte-derived macrophages through inhibition of the mevalonate-geranylgeranyl pyrophosphate-RhoA-p38 mitogen-activated protein kinase pathway. 2011 Feb 1
19 20614159 Simvastatin overcomes the resistance to serum withdrawal-induced apoptosis of lymphocytes from Alzheimer's disease patients. 2010 Dec 1
20 20671065 High-density lipoprotein induces proliferation and migration of human prostate androgen-independent cancer cells by an ABCA1-dependent mechanism. 2010 Sep 1
21 17464346 The inhibitory effect of simvastatin on the ADMA-induced inflammatory reaction is mediated by MAPK pathways in endothelial cells. 2007 Feb 2
22 15069546 Effects of an HMG-CoA reductase inhibitor, simvastatin, on human myeloma cells. 2004 May 1