Gefitinib

mitogen-activated protein kinase 3 ; Homo sapiens







44 Article(s)
Download
PMID
Title
Pub. Year
#Total Relationships
1 30474276 Gelatin nonwovens-based epithelial morphogenesis involves a signaling axis comprising EGF-receptor, MAP kinases ERK 1/2, and β1 integrin. 2019 Mar 1
2 31454111 Epiregulin enhances odontoblastic differentiation of dental pulp stem cells via activating MAPK signalling pathway. 2019 Nov 1
3 29215723 High cholesterol in lipid rafts reduces the sensitivity to EGFR-TKI therapy in non-small cell lung cancer. 2018 Sep 1
4 29480364 Combination of S-1 and gefitinib increases the sensitivity to radiotherapy in lung cancer cells. 2018 Apr 1
5 29517107 FGFR inhibitor AZD4547 can enhance sensitivity of esophageal squamous cell carcinoma cells with epithelial‑mesenchymal transition to gefitinib. 2018 May 1
6 29383165 Gefitinib enhances sensitivity of endometrial cancer cells to progestin therapy via dual-specificity phosphatase 1. 2017 Dec 29 1
7 27716616 Ran GTPase promotes cancer progression via Met recepto-rmediated downstream signaling. 2016 Nov 15 1
8 25662161 Down-regulation of ERK1/2 and AKT-mediated X-ray repair cross-complement group 1 protein (XRCC1) expression by Hsp90 inhibition enhances the gefitinib-induced cytotoxicity in human lung cancer cells. 2015 May 15 5
9 25879333 The effects of combination of gefitinib and cisplatin on tongue squamous cell carcinoma cell lines. 2015 Jan-Mar 1
10 26176330 The small GTPase ADP-Ribosylation Factor 1 mediates the sensitivity of triple negative breast cancer cells to EGFR tyrosine kinase inhibitors. 2015 1
11 26517520 244-MPT overcomes gefitinib resistance in non-small cell lung cancer cells. 2015 Dec 29 1
12 24884778 Enhancement of gefitinib-induced growth inhibition by Marsdenia tenacissima extract in non-small cell lung cancer cells expressing wild or mutant EGFR. 2014 May 22 2
13 23533381 Combined Effects of PPAR γ Agonists and Epidermal Growth Factor Receptor Inhibitors in Human Proximal Tubule Cells. 2013 1
14 24034993 [c-Met signaling pathway participating in the gefitinib resistance of different gene types of non-small cell lung cancer cells induced by HGF in vitro]. 2013 Sep 1
15 24146879 Induction of autophagy is an early response to gefitinib and a potential therapeutic target in breast cancer. 2013 1
16 21544845 Regulation of cigarette smoke-mediated mucin expression by hypoxia-inducible factor-1α via epidermal growth factor receptor-mediated signaling pathways. 2012 Apr 3
17 21787763 Receptor tyrosine kinase inhibitors and cytotoxic drugs affect pleural mesothelioma cell proliferation: insight into EGFR and ERK1/2 as antitumor targets. 2011 Nov 15 2
18 19760159 Lovastatin overcomes gefitinib resistance in human non-small cell lung cancer cells with K-Ras mutations. 2010 Dec 1
19 19922467 EGF receptor in relation to tumor development: molecular basis of responsiveness of cancer cells to EGFR-targeting tyrosine kinase inhibitors. 2010 Jan 1
20 20088784 Gefitinib targets EGFR dimerization and ERK1/2 phosphorylation to inhibit pleural mesothelioma cell proliferation. 2010 Mar 2
21 19147502 Different response of human glioma tumor-initiating cells to epidermal growth factor receptor kinase inhibitors. 2009 Mar 13 1
22 19157634 The role of celecoxib in Rad51 expression and cell survival affected by gefitinib in human non-small cell lung cancer cells. 2009 Sep 2
23 19233551 Bisphosphonate zoledronic acid enhances the inhibitory effects of gefitinib on EGFR-mutated non-small cell lung carcinoma cells. 2009 Jun 8 1
24 19318490 Proteomic signatures of epidermal growth factor receptor and survival signal pathways correspond to gefitinib sensitivity in head and neck cancer. 2009 Apr 1 1
25 19380191 Epidermal growth factor competes with EGF receptor inhibitors to induce cell death in EGFR-overexpressing tumor cells. 2009 Oct 8 1
26 19505457 Emodin enhances gefitinib-induced cytotoxicity via Rad51 downregulation and ERK1/2 inactivation. 2009 Sep 10 2
27 17959712 17beta-estradiol promotes breast cancer cell proliferation-inducing stromal cell-derived factor-1-mediated epidermal growth factor receptor transactivation: reversal by gefitinib pretreatment. 2008 Jan 1
28 18292095 Epidermal growth factor plays a crucial role in mitogenic regulation of human brain tumor stem cells. 2008 Apr 18 1
29 18347153 Modulation of survival pathways in ovarian carcinoma cell lines resistant to platinum compounds. 2008 Mar 1
30 18377894 The role of repair protein Rad51 in synergistic cytotoxicity and mutagenicity induced by epidermal growth factor receptor inhibitor (Gefitinib, IressaR) and benzo[a]pyrene in human lung cancer. 2008 May 1 5
31 18544565 Involvement of Rad51 in cytotoxicity induced by epidermal growth factor receptor inhibitor (gefitinib, IressaR) and chemotherapeutic agents in human lung cancer cells. 2008 Jul 6
32 18980991 Autocrine production of amphiregulin predicts sensitivity to both gefitinib and cetuximab in EGFR wild-type cancers. 2008 Nov 1 1
33 19001445 Role of repair protein Rad51 in regulating the response to gefitinib in human non-small cell lung cancer cells. 2008 Nov 4
34 17270025 Activation of downstream epidermal growth factor receptor (EGFR) signaling provides gefitinib-resistance in cells carrying EGFR mutation. 2007 Mar 1
35 17409805 The effect of gefitinib on B-RAF mutant non-small cell lung cancer and transfectants. 2007 Apr 1
36 17686159 Heregulin beta1 drives gefitinib-resistant growth and invasion in tamoxifen-resistant MCF-7 breast cancer cells. 2007 2
37 17699786 Emergence of epidermal growth factor receptor T790M mutation during chronic exposure to gefitinib in a non small cell lung cancer cell line. 2007 Aug 15 1
38 16261397 Bidirectional cross talk between ERalpha and EGFR signalling pathways regulates tamoxifen-resistant growth. 2006 Mar 1
39 16568376 Gefitinib and the modulation of the signaling pathways downstream of epidermal growth factor receptor in human liver cancer cells. 2006 Feb 2
40 16937523 Prolonged exposure of colon cancer cells to the epidermal growth factor receptor inhibitor gefitinib (Iressa(TM)) and to the antiangiogenic agent ZD6474: Cytotoxic and biomolecular effects. 2006 Aug 28 1
41 16106023 Differential effects of gefitinib and cetuximab on non-small-cell lung cancers bearing epidermal growth factor receptor mutations. 2005 Aug 17 1
42 15078990 Sensitivity to gefitinib (Iressa, ZD1839) in non-small cell lung cancer cell lines correlates with dependence on the epidermal growth factor (EGF) receptor/extracellular signal-regulated kinase 1/2 and EGF receptor/Akt pathway for proliferation. 2004 Apr 2
43 15582135 Targeting the epidermal growth factor receptor by gefitinib for treatment of hepatocellular carcinoma. 2004 Dec 1
44 12234991 Inhibition of epidermal growth factor receptor signaling in malignant pleural mesothelioma. 2002 Sep 15 1