2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one

mitogen-activated protein kinase 3 ; Homo sapiens







106 Article(s)
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1 34875308 Reconstituted HDL-apoE3 promotes endothelial cell migration through ID1 and its downstream kinases ERK1/2, AKT and p38 MAPK. 2022 Feb 1
2 33037575 Folic Acid Deficiency Enhances the Tyr705 and Ser727 Phosphorylation of Mitochondrial STAT3 in In Vivo and In Vitro Models of Ischemic Stroke. 2021 Oct 1
3 33258087 Mechanism of Human Umbilical Cord Mesenchymal Stem Cells Derived-Extracellular Vesicle in Cerebral Ischemia-Reperfusion Injury. 2021 Mar 1
4 32318240 Kaji-Ichigoside F1 and Rosamultin Protect Vascular Endothelial Cells against Hypoxia-Induced Apoptosis via the PI3K/AKT or ERK1/2 Signaling Pathway. 2020 1
5 32392915 Heat shock protein 90 inhibitor AUY922 attenuates platelet-derived growth factor-BB-induced migration and proliferation of vascular smooth muscle cells. 2020 May 1 1
6 32395075 Heat shock protein 90 inhibitor AUY922 attenuates platelet-derived growth factor-BB-induced migration and proliferation of vascular smooth muscle cells. 2020 May 1 1
7 32630394 Esculetin as a Bifunctional Antioxidant Prevents and Counteracts the Oxidative Stress and Neuronal Death Induced by Amyloid Protein in SH-SY5Y Cells. 2020 Jun 25 1
8 33317626 ELABELA ameliorates hypoxic/ischemic-induced bone mesenchymal stem cell apoptosis via alleviation of mitochondrial dysfunction and activation of PI3K/AKT and ERK1/2 pathways. 2020 Dec 14 1
9 33334784 Akt Downregulates B-Cell Translocation Gene-2 Expression Via Erk1/2 Inhibition for Proliferation of Cancer Cells. 2020 Nov 1
10 30745840 RRM2 is a potential prognostic biomarker with functional significance in glioma. 2019 1
11 29248464 Decanoic acid suppresses proliferation and invasiveness of human trophoblast cells by disrupting mitochondrial function. 2018 Jan 15 1
12 29319206 Butyl paraben promotes apoptosis in human trophoblast cells through increased oxidative stress-induced endoplasmic reticulum stress. 2018 Apr 1
13 29461611 Leptin inhibits apoptosis of nucleus pulposus cells via promoting autophagy. 2018 Feb 2
14 29766336 Ischaemic Preconditioning Protects Cardiomyocytes from Anthracycline-Induced Toxicity via the PI3K Pathway. 2018 Jun 1
15 29928334 Inhibition of the PI3K/Akt signaling pathway reverses sorafenib-derived chemo-resistance in hepatocellular carcinoma. 2018 Jun 1
16 30409306 Crosstalk between Raf-MEK-ERK and PI3K-Akt-GSK3β signaling networks promotes chemoresistance, invasion/migration and stemness via expression of CD44 variants (v4 and v6) in oral cancer. 2018 Nov 1
17 27171670 Chrysophanol Induces Apoptosis of Choriocarcinoma Through Regulation of ROS and the AKT and ERK1/2 Pathways. 2017 Feb 1
18 27400655 H4R activation utilizes distinct signaling pathways for the production of RANTES and IL-13 in human mast cells. 2017 Apr 1
19 27702388 Epidermal Growth Factor Induces Proliferation of Hair Follicle-Derived Mesenchymal Stem Cells Through Epidermal Growth Factor Receptor-Mediated Activation of ERK and AKT Signaling Pathways Associated with Upregulation of Cyclin D1 and Downregulation of p16. 2017 Jan 15 1
20 28103512 Protein O-fucosyltransferase 1 promotes trophoblast cell proliferation through activation of MAPK and PI3K/Akt signaling pathways. 2017 Apr 1
21 28185818 Amentoflavone protects dopaminergic neurons in MPTP-induced Parkinson's disease model mice through PI3K/Akt and ERK signaling pathways. 2017 Mar 15 1
22 28197636 miR-21 and KLF4 jointly augment epithelial‑mesenchymal transition via the Akt/ERK1/2 pathway. 2017 Apr 1
23 28833753 Lactoferrin induces tropoelastin expression by activating the lipoprotein receptor-related protein 1-mediated phosphatidylinositol 3-kinase/Akt pathway in human dermal fibroblasts. 2017 Dec 1
24 28940899 Low-intensity pulsed ultrasound activates ERK1/2 and PI3K-Akt signalling pathways and promotes the proliferation of human amnion-derived mesenchymal stem cells. 2017 Dec 1
25 28983584 Na+/K+‑ATPase DR region‑specific antibody protects U251 cells against hypoxia reperfusion‑induced injury via the PI3K/AKT and ERK pathways. 2017 Dec 1
26 26234766 PDGF-D promotes dermal fibroblast invasion in 3-dimensional extracellular matrix via Snail-mediated MT1-MMP upregulation. 2016 Jan 1
27 26915319 Inhibitory effect of luteolin on the proliferation of human breast cancer cell lines induced by epidermal growth factor. 2016 Feb 25 1
28 26940012 MAT2B promotes adipogenesis by modulating SAMe levels and activating AKT/ERK pathway during porcine intramuscular preadipocyte differentiation. 2016 May 15 1
29 27035160 Salinomycin causes migration and invasion of human fibrosarcoma cells by inducing MMP-2 expression via PI3-kinase, ERK-1/2 and p38 kinase pathways. 2016 Jun 1
30 27208795 Biased signaling initiated by agouti-related peptide through human melanocortin-3 and -4 receptors. 2016 Sep 1
31 25748730 Paeoniflorin diminishes ConA-induced IL-8 production in primary human hepatic sinusoidal endothelial cells in the involvement of ERK1/2 and Akt phosphorylation. 2015 May 1
32 25917210 Geraniin exerts cytoprotective effect against cellular oxidative stress by upregulation of Nrf2-mediated antioxidant enzyme expression via PI3K/AKT and ERK1/2 pathway. 2015 Sep 1
33 26138882 Beyond Gap Junction Channel Function: the Expression of Cx43 Contributes to Aldosterone-Induced Mesangial Cell Proliferation via the ERK1/2 and PKC Pathways. 2015 1
34 23604952 Platelet-rich plasma releasate promotes angiogenesis in vitro and in vivo. 2014 Jun 1
35 24441870 TNF-α induces cytosolic phospholipase A2 expression via Jak2/PDGFR-dependent Elk-1/p300 activation in human lung epithelial cells. 2014 Mar 15 2
36 24451985 Stimulatory Effect of Vascular Endothelial Growth Factor on Proliferation and Migration of Porcine Trophectoderm Cells and Their Regulation by the Phosphatidylinositol-3-Kinase-AKT and Mitogen-Activated Protein Kinase Cell Signaling Pathways. 2014 Mar 2
37 24488601 Neuroprotective effects of 3,6'-disinapoyl sucrose through increased BDNF levels and CREB phosphorylation via the CaMKII and ERK1/2 pathway. 2014 Aug 1
38 24520418 Proliferation-stimulating effect of colony stimulating factor 2 on porcine trophectoderm cells is mediated by activation of phosphatidylinositol 3-kinase and extracellular signal-regulated kinase 1/2 mitogen-activated protein kinase. 2014 1
39 24805814 BMP9 inhibits proliferation and metastasis of HER2-positive SK-BR-3 breast cancer cells through ERK1/2 and PI3K/AKT pathways. 2014 1
40 25068805 The effect of estrogen on the proliferation of endometrial cancer cells is mediated by ERRγ through AKT and ERK1/2. 2014 Sep 1
41 25146167 Complex interactions between the components of the PI3K/AKT/mTOR pathway, and with components of MAPK, JAK/STAT and Notch-1 pathways, indicate their involvement in meningioma development. 2014 Oct 1
42 23161148 Neuroprotection of interleukin-6 against NMDA-induced neurotoxicity is mediated by JAK/STAT3, MAPK/ERK, and PI3K/AKT signaling pathways. 2013 Mar 1
43 23363008 Chicoric acid induces apoptosis in 3T3-L1 preadipocytes through ROS-mediated PI3K/Akt and MAPK signaling pathways. 2013 Feb 20 1
44 24012499 Nicotinic acetylcholine receptor antagonists alter the function and expression of serine racemase in PC-12 and 1321N1 cells. 2013 Dec 2
45 24200059 [Changes and regulatory mechanism of tight junction proteins in in vitro model of lead-induced blood-brain barrier injury]. 2013 Nov 1
46 21544845 Regulation of cigarette smoke-mediated mucin expression by hypoxia-inducible factor-1α via epidermal growth factor receptor-mediated signaling pathways. 2012 Apr 1
47 21769475 Interleukin-6 up-regulates the expression of interleukin-15 is associated with MAPKs and PI3-K signaling pathways in the human keratinocyte cell line, HaCaT. 2012 Apr 1
48 22925659 PI3K-ERK1/2 activation contributes to extracellular H2O2 generation in amyloid β toxicity. 2012 Sep 27 1
49 21215800 Tyrosine kinase-independent activation of extracellular-regulated kinase (ERK) 1/2 by the insulin-like growth factor-1 receptor. 2011 Apr 1
50 21536288 Monocyte chemotactic protein-3 induces human coronary smooth muscle cell proliferation. 2011 Jul 1