Cisplatin

mitogen-activated protein kinase 3 ; Homo sapiens







80 Article(s)
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51 23041051 The kinase RSK2 modulates the sensitivity of ovarian cancer cells to cisplatin. 2013 Jan 1
52 23042098 MAPK signaling in cisplatin-induced death: predominant role of ERK1 over ERK2 in human hepatocellular carcinoma cells. 2013 Jan 12
53 23338561 Antitumor properties of salinomycin on cisplatin-resistant human ovarian cancer cells in vitro and in vivo: involvement of p38 MAPK activation. 2013 Apr 1
54 23783141 Activation of ERK1/2 and Akt is associated with cisplatin resistance in human lung cancer cells. 2013 Jun 7
55 24335178 Potential molecular mechanisms for improved prognosis and outcome with neoadjuvant chemotherapy prior to laparoscopical radical hysterectomy for patients with cervical cancer. 2013 1
56 22179790 RNAi-mediated knockdown of ERK1/2 inhibits cell proliferation and invasion and increases chemosensitivity to cisplatin in human osteosarcoma U2-OS cells in vitro. 2012 Apr 2
57 21130731 Acquisition of chemoresistance in intrahepatic cholangiocarcinoma cells by activation of AKT and extracellular signal-regulated kinase (ERK)1/2. 2011 Feb 18 2
58 21444628 Up-regulation of extracellular signal-regulated kinase 1/2-dependent thymidylate synthase and thymidine phosphorylase contributes to cisplatin resistance in human non-small-cell lung cancer cells. 2011 Jul 5
59 21687949 Tubeimoside I sensitizes cisplatin in cisplatin-resistant human ovarian cancer cells (A2780/DDP) through down-regulation of ERK and up-regulation of p38 signaling pathways. 2011 Sep-Oct 1
60 19962780 Emodin enhances cisplatin-induced cytotoxicity via down-regulation of ERCC1 and inactivation of ERK1/2. 2010 Aug 5
61 18661133 Characterization of kinase suppressor of Ras-1 expression and anticancer drug sensitivity in human cancer cell lines. 2009 Apr 1
62 19428505 Role of MAPKs in platinum-induced neuronal apoptosis. 2009 Mar 1
63 17942395 Epidermal growth factor receptor pathway analysis identifies amphiregulin as a key factor for cisplatin resistance of human breast cancer cells. 2008 Jan 11 3
64 18093981 A sensitive flow cytometry-based nucleotide excision repair assay unexpectedly reveals that mitogen-activated protein kinase signaling does not regulate the removal of UV-induced DNA damage in human cells. 2008 Feb 29 1
65 18332870 Cisplatin treatment increases survival and expansion of a highly tumorigenic side-population fraction by upregulating VEGF/Flt1 autocrine signaling. 2008 Jun 26 2
66 18425342 Constitutive activation of p70 S6 kinase is associated with intrinsic resistance to cisplatin. 2008 May 3
67 18544565 Involvement of Rad51 in cytotoxicity induced by epidermal growth factor receptor inhibitor (gefitinib, IressaR) and chemotherapeutic agents in human lung cancer cells. 2008 Jul 3
68 17023032 A high nuclear basal level of ERK2 phosphorylation contributes to the resistance of cisplatin-resistant human ovarian cancer cells. 2007 Feb 1
69 17125914 Activation of mitogen-activated protein kinases by cisplatin and their role in cisplatin-resistance. 2007 Jun 18 2
70 17508026 ERK1/2 is highly phosphorylated in melanoma metastases and protects melanoma cells from cisplatin-mediated apoptosis. 2007 Sep 1
71 17513610 Expression of human glutathione S-transferase P1 mediates the chemosensitivity of osteosarcoma cells. 2007 May 2
72 17982682 Erythropoietin reduces cisplatin-induced neurotoxicity without impairment of cytotoxic effects against tumor cells. 2007 Dec 2
73 16395709 p38 MAPK turns hepatocyte growth factor to a death signal that commits ovarian cancer cells to chemotherapy-induced apoptosis. 2006 Jun 15 2
74 16723633 Polynuclear platinum anticancer drugs are more potent than cisplatin and induce cell cycle arrest in glioma. 2006 Jul 1
75 15843040 Pharmacological inhibitors of extracellular signal-regulated protein kinases attenuate the apoptotic action of cisplatin in human myeloid leukemia cells via glutathione-independent reduction in intracellular drug accumulation. 2005 Apr 15 3
76 16039614 Activation of ERK during DNA damage-induced apoptosis involves protein kinase Cdelta. 2005 Sep 9 2
77 15250250 Role of ERK1/2 kinase in cisplatin-induced apoptosis in human ovarian carcinoma cells. 2004 Jun 2
78 12439598 Ras-mediated activation of ERK by cisplatin induces cell death independently of p53 in osteosarcoma and neuroblastoma cell lines. 2002 Nov 1
79 11170260 Cisplatin-induced response of c-jun N-terminal kinase 1 and extracellular signal--regulated protein kinases 1 and 2 in a series of cisplatin-resistant ovarian carcinoma cell lines. 2000 Dec 19
80 10353733 Cisplatin-induced activation of mitogen-activated protein kinases in ovarian carcinoma cells: inhibition of extracellular signal-regulated kinase activity increases sensitivity to cisplatin. 1999 May 11