Doxorubicin

mitogen-activated protein kinase 3 ; Homo sapiens







55 Article(s)
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1 35395977 [Effect of Doxycycline on Intrinsic Apoptosis of Myeloma Cell Line H929 and Its Mechanism]. 2022 Apr 2
2 32562081 Methylsulfonylmethane sensitizes endometrial cancer cells to doxorubicin. 2021 Apr 1
3 34471052 Apoptosis Inducing Activity of Rhinacanthin-C in Doxorubicin-Resistant Breast Cancer MCF-7 Cells. 2021 1
4 34565287 Silencing Aurora-kinase-A (AURKA) reinforced the sensitivity of diffuse large B-cell lymphoma cells to cyclophosphamide, doxorubicin, vincristine, and prednisone (CHOP) via suppressing β-Catenin and RAS-extracellular signal-regulated protein kinase (ERK1/2) pathway. 2021 Dec 1
5 34749347 DOX-loaded silver nanotriangles and photothermal therapy exert a synergistic antibreast cancer effect via ROS/ERK1/2 signaling pathway. 2021 Nov 22 1
6 34830320 Doxorubicin-Resistant TNBC Cells Exhibit Rapid Growth with Cancer Stem Cell-like Properties and EMT Phenotype, Which Can Be Transferred to Parental Cells through Autocrine Signaling. 2021 Nov 18 1
7 31843629 Parameritannin A-2 from Urceola huaitingii enhances doxorubicin-induced mitochondria-dependent apoptosis by inhibiting the PI3K/Akt, ERK1/2 and p38 pathways in gastric cancer cells. 2020 Jan 25 4
8 32277647 Phloretin flavonoid exhibits selective antiproliferative activity in doxorubicin-resistant gastric cancer cells by inducing autophagy, inhibiting cell migration and invasion, cell cycle arrest and targeting ERK1/2 MAP pathway. 2020 Jan-Feb 1
9 32722178 The Long-Lasting Protective Effect of HGF in Cardiomyoblasts Exposed to Doxorubicin Requires a Positive Feed-Forward Loop Mediated by Erk1,2-Timp1-Stat3. 2020 Jul 24 2
10 33204396 Cellular Mechanisms Triggered by the Cotreatment of Resveratrol and Doxorubicin in Breast Cancer: A Translational In Vitro-In Silico Model. 2020 1
11 30939040 miR-132 Regulates Adriamycin Resistance in Colorectal Cancer Cells Through Targeting Extracellular Signal-Regulated Kinase 1. 2019 Aug 2
12 31356549 Curdione Ameliorated Doxorubicin-Induced Cardiotoxicity Through Suppressing Oxidative Stress and Activating Nrf2/HO-1 Pathway. 2019 Aug 1
13 31377057 Inhibition of the ERK1/2-mTORC1 axis ameliorates proteinuria and the fibrogenic action of transforming growth factor-β in Adriamycin-induced glomerulosclerosis. 2019 Oct 1
14 28295305 Mitochondrial ROS-induced ERK1/2 activation and HSF2-mediated AT1 R upregulation are required for doxorubicin-induced cardiotoxicity. 2018 Jan 3
15 28328292 IL-6 is involved in malignancy and doxorubicin sensitivity of renal carcinoma cells. 2018 Jan 2 1
16 29352988 STAT3 as a promising chemoresistance biomarker associated with the CD44+/high/CD24-/low/ALDH+ BCSCs-like subset of the triple-negative breast cancer (TNBC) cell line. 2018 Feb 15 1
17 29574069 Forskolin improves sensitivity to doxorubicin of triple negative breast cancer cells via Protein Kinase A-mediated ERK1/2 inhibition. 2018 Jun 1
18 29795329 Integration of Ca2+ signaling regulates the breast tumor cell response to simvastatin and doxorubicin. 2018 Sep 1
19 27585662 Growth Hormone differentially modulates chemoresistance in human endometrial adenocarcinoma cell lines. 2017 Jun 1
20 27649518 Inhibition of the PI3K/AKT Pathway Sensitizes Oral Squamous Cell Carcinoma Cells to Anthracycline-Based Chemotherapy In Vitro. 2017 Sep 3
21 28098907 Synergistic combination of YS-1 and adriamycin inhibits human renal cancer through ERK1/2 signaling pathway in vitro and in vivo. 2017 Mar 1
22 28218042 Doxorubicin has a synergistic cytotoxicity with cucurbitacin B in anaplastic thyroid carcinoma cells. 2017 Feb 1
23 28476801 Azacytidine-induced Chemosensitivity to Doxorubicin in Human Breast Cancer MCF7 Cells. 2017 May 1
24 28627650 The inhibitory effects of deep-sea water on doxorubicin‑induced epithelial-mesenchymal transition. 2017 Aug 1
25 29061787 (-)-Epigallocatechin-3-gallate Down-regulates Doxorubicin-induced Overexpression of P-glycoprotein Through the Coordinate Inhibition of PI3K/Akt and MEK/ERK Signaling Pathways. 2017 Nov 2
26 26505786 Combinatorial Effects of Curcumin with an Anti-Neoplastic Agent on Head and Neck Squamous Cell Carcinoma Through the Regulation of EGFR-ERK1/2 and Apoptotic Signaling Pathways. 2016 Jan 11 1
27 26969380 Sinapine reverses multi-drug resistance in MCF-7/dox cancer cells by downregulating FGFR4/FRS2α-ERK1/2 pathway-mediated NF-κB activation. 2016 Mar 15 1
28 27510278 A targeted proteomics approach to the quantitative analysis of ERK/Bcl-2-mediated anti-apoptosis and multi-drug resistance in breast cancer. 2016 Oct 2
29 27754360 Rack1 Mediates the Interaction of P-Glycoprotein with Anxa2 and Regulates Migration and Invasion of Multidrug-Resistant Breast Cancer Cells. 2016 Oct 13 1
30 25968898 CBP-dependent Wnt/β-catenin signaling is crucial in regulation of MDR1 transcription. 2015 1
31 26299281 Hydrogen sulfide attenuates doxorubicin-induced cardiotoxicity by inhibiting reactive oxygen species-activated extracellular signal-regulated kinase 1/2 in H9c2 cardiac myocytes. 2015 Nov 4
32 26340617 Inorganic Phosphate Prevents Erk1/2 and Stat3 Activation and Improves Sensitivity to Doxorubicin of MDA-MB-231 Breast Cancer Cells. 2015 Sep 1 1
33 26459009 Downregulation of P-gp, Ras and p-ERK1/2 contributes to the arsenic trioxide-induced reduction in drug resistance towards doxorubicin in gastric cancer cell lines. 2015 Nov 2
34 26658818 Protective effects of madecassoside against Doxorubicin induced nephrotoxicity in vivo and in vitro. 2015 Dec 14 2
35 22674530 Inorganic phosphate enhances sensitivity of human osteosarcoma U2OS cells to doxorubicin via a p53-dependent pathway. 2013 Jan 1
36 23232767 Overexpression of Yes-associated protein confers doxorubicin resistance in hepatocellullar carcinoma. 2013 Feb 1
37 23877402 Anticancer effects of Ac‑Phe‑Lys‑PABC‑doxorubicin via mitochondria‑centered apoptosis involving reactive oxidative stress and the ERK1/2 signaling pathway in MGC‑803 cells. 2013 Oct 3
38 23965518 The sulphydryl containing ACE inhibitor Zofenoprilat protects coronary endothelium from Doxorubicin-induced apoptosis. 2013 Oct 1
39 22282250 Involvement of MMP-2 in adriamycin resistance dependent on ERK1/2 signal pathway in human osteosarcoma MG-63 cells. 2012 Feb 2
40 23133614 Silencing prion protein in MDA-MB-435 breast cancer cells leads to pleiotropic cellular responses to cytotoxic stimuli. 2012 2
41 23493035 Different Expression of Extracellular Signal-Regulated Kinases (ERK) 1/2 and Phospho-Erk Proteins in MBA-MB-231 and MCF-7 Cells after Chemotherapy with Doxorubicin or Docetaxel. 2012 Jan 3
42 21314951 Soluble Frizzled-7 receptor inhibits Wnt signaling and sensitizes hepatocellular carcinoma cells towards doxorubicin. 2011 Feb 11 1
43 21790999 Inhibition of doxorubicin-induced autophagy in hepatocellular carcinoma Hep3B cells by sorafenib--the role of extracellular signal-regulated kinase counteraction. 2011 Sep 1
44 19913499 PFT-alpha inhibits antibody-induced activation of p53 and pro-apoptotic signaling in 1-LN prostate cancer cells. 2010 Jan 1 1
45 20428768 Low doses of ionizing radiation suppress doxorubicin-induced senescence-like phenotypes by activation of ERK1/2 and suppression of p38 kinase in MCF7 human breast cancer cells. 2010 Jun 2
46 21159167 Blocking of ERK1 and ERK2 sensitizes human mesothelioma cells to doxorubicin. 2010 Dec 15 4
47 19417026 Mitogen-activated protein kinase phosphatase-1 in human breast cancer independently predicts prognosis and is repressed by doxorubicin. 2009 May 15 4
48 18164246 The volume-sensitive chloride channel inhibitors prevent both contractile dysfunction and apoptosis induced by doxorubicin through PI3kinase, Akt and Erk 1/2. 2008 Jan 2
49 18594523 Chemosensitisation by manganese superoxide dismutase inhibition is caspase-9 dependent and involves extracellular signal-regulated kinase 1/2. 2008 Jul 22 1
50 18974122 A novel association between p130Cas and resistance to the chemotherapeutic drug adriamycin in human breast cancer cells. 2008 Nov 1 2