Melatonin

mitogen-activated protein kinase 3 ; Homo sapiens







41 Article(s)
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1 35298069 Melatonin inhibits EMT and PD-L1 expression through the ERK1/2/FOSL1 pathway and regulates anti-tumor immunity in HNSCC. 2022 Mar 17 3
2 33369155 Melatonin inhibiting the survival of human gastric cancer cells under ER stress involving autophagy and Ras-Raf-MAPK signalling. 2021 Feb 3
3 34188711 Melatonin inhibits gallbladder cancer cell migration and invasion via ERK-mediated induction of epithelial-to-mesenchymal transition. 2021 Aug 1
4 32052470 Melatonin enhances thrombopoiesis through ERK1/2 and Akt activation orchestrated by dual adaptor for phosphotyrosine and 3-phosphoinositides. 2020 Apr 4
5 32179814 Usefulness of melatonin as complementary to chemotherapeutic agents at different stages of the angiogenic process. 2020 Mar 16 2
6 31081481 Melatonin attenuates expression of cyclooxygenase-2 (COX-2) in activated microglia induced by lipopolysaccharide (LPS). 2019 1
7 31354524 Melatonin Enhances the Usefulness of Ionizing Radiation: Involving the Regulation of Different Steps of the Angiogenic Process. 2019 1
8 31717992 Melatonin Inhibits Transforming Growth Factor-β1-Induced Epithelial-Mesenchymal Transition in AML12 Hepatocytes. 2019 Nov 11 1
9 31836786 Interaction of melatonin and Bmal1 in the regulation of PI3K/AKT pathway components and cellular survival. 2019 Dec 13 1
10 31885798 Melatonin Protects Intervertebral Disc from Degeneration by Improving Cell Survival and Function via Activation of the ERK1/2 Signaling Pathway. 2019 3
11 29285799 Biological effects of melatonin on osteoblast/osteoclast cocultures, bone, and quality of life: Implications of a role for MT2 melatonin receptors, MEK1/2, and MEK5 in melatonin-mediated osteoblastogenesis. 2018 Apr 2
12 29766567 Melatonin attenuates osteosarcoma cell invasion by suppression of C-C motif chemokine ligand 24 through inhibition of the c-Jun N-terminal kinase pathway. 2018 Oct 1
13 30245469 Melatonin improves vascular cognitive impairment induced by ischemic stroke by remyelination via activation of ERK1/2 signaling and restoration of glutamatergic synapses in the gerbil hippocampus. 2018 Dec 4
14 30349079 Melatonin suppresses TLR9-triggered proinflammatory cytokine production in macrophages by inhibiting ERK1/2 and AKT activation. 2018 Oct 22 3
15 26607298 Melatonin suppression of aerobic glycolysis (Warburg effect), survival signalling and metastasis in human leiomyosarcoma. 2016 Mar 1
16 26639427 Targeting different pathophysiological events after traumatic brain injury in mice: Role of melatonin and memantine. 2016 Jan 26 1
17 26732239 Melatonin inhibits MMP-9 transactivation and renal cell carcinoma metastasis by suppressing Akt-MAPKs pathway and NF-κB DNA-binding activity. 2016 Apr 1
18 26980735 Melatonin inhibits TPA-induced oral cancer cell migration by suppressing matrix metalloproteinase-9 activation through the histone acetylation. 2016 Apr 19 1
19 27832629 Inhibition of ERK1/2 Signaling Pathway is Involved in Melatonin's Antiproliferative Effect on Human MG-63 Osteosarcoma Cells. 2016 6
20 25281200 Cytoprotective effect of melatonin against hypoxia/serum deprivation-induced cell death of bone marrow mesenchymal stem cells in vitro. 2015 Feb 5 7
21 25393881 The melatonin-N,N-dibenzyl(N-methyl)amine hybrid ITH91/IQM157 affords neuroprotection in an in vitro Alzheimer's model via hemo-oxygenase-1 induction. 2015 Feb 18 1
22 25491598 Melatonin stimulates the nonamyloidogenic processing of βAPP through the positive transcriptional regulation of ADAM10 and ADAM17. 2015 Mar 1
23 25857269 Doxorubicin resistance in breast cancer is driven by light at night-induced disruption of the circadian melatonin signal. 2015 Aug 1
24 25961946 Effect of Melatonin on the Extracellular-Regulated Kinase Signal Pathway Activation and Human Osteoblastic Cell Line hFOB 1.19 Proliferation. 2015 May 7 2
25 26359987 Melatonin Contributes to the Seasonality of Multiple Sclerosis Relapses. 2015 Sep 10 1
26 24372669 Molecular deficiency (ies) in MT₁ melatonin signaling pathway underlies the melatonin-unresponsive phenotype in MDA-MB-231 human breast cancer cells. 2014 Apr 1
27 24720799 Melatonin inhibits MUC5AC production via suppression of MAPK signaling in human airway epithelial cells. 2014 May 5
28 24724723 Melatonin receptor type 1 signals to extracellular signal-regulated kinase 1 and 2 via Gi and Gs dually coupled pathways in HEK-293 cells. 2014 May 6 3
29 24739710 Melatonin regulates human bone sialoprotein gene transcription. 2014 Mar 1
30 24942200 Melatonin promotes the acquisition of neural identity through extracellular-signal-regulated kinases 1/2 activation. 2014 Sep 1
31 25562159 Melatonin protects the esophageal epithelial barrier by suppressing the transcription, expression and activity of myosin light chain kinase through ERK1/2 signal transduction. 2014 2
32 23276991 Cardioprotective effect of melatonin against ischaemia/reperfusion damage. 2013 Jan 1 1
33 21951103 Melatonin suppresses acrolein-induced IL-8 production in human pulmonary fibroblasts. 2012 Apr 2
34 22348531 Melatonin suppresses proinflammatory mediators in lipopolysaccharide-stimulated CRL1999 cells via targeting MAPK, NF-κB, c/EBPβ, and p300 signaling. 2012 Sep 1
35 21392094 Melatonin promotes proliferation and differentiation of neural stem cells subjected to hypoxia in vitro. 2011 Aug 1
36 20382690 Melatonin sensitizes human myometrial cells to oxytocin in a protein kinase C alpha/extracellular-signal regulated kinase-dependent manner. 2010 Jun 1
37 20626586 Determination of the minimal melatonin exposure required to induce osteoblast differentiation from human mesenchymal stem cells and these effects on downstream signaling pathways. 2010 Oct 1
38 18930812 ERK MAPK activation mediates the antiapoptotic signaling of melatonin in UVB-stressed U937 cells. 2009 Feb 1 7
39 19486272 Antineoplastic effects of melatonin on a rare malignancy of mesenchymal origin: melatonin receptor-mediated inhibition of signal transduction, linoleic acid metabolism and growth in tissue-isolated human leiomyosarcoma xenografts. 2009 Aug 1
40 16635021 Melatonin enhances alkaline phosphatase activity in differentiating human adult mesenchymal stem cells grown in osteogenic medium via MT2 melatonin receptors and the MEK/ERK (1/2) signaling cascade. 2006 May 2
41 10842331 Melatonin induction of filamentous structures in non-neuronal cells that is dependent on expression of the human mt1 melatonin receptor. 2000 May 1