| 1 |
33812052 | Identification of novel pregnane X receptor (PXR) agonists by In silico and biological activity analyses and reversal of cigarette smoke-induced PXR downregulation. | 2021 May 28 |
2 |
| 2 |
34084152 | A Comparative Study of Human and Zebrafish Pregnane X Receptor Activities of Pesticides and Steroids Using In Vitro Reporter Gene Assays. | 2021 |
1 |
| 3 |
34524495 | Megestrol acetate is a specific inducer of CYP3A4 mediated by human pregnane X receptor. | 2021 Dec |
1 |
| 4 |
32352317 | Evaluating the Role of the Steroid and Xenobiotic Receptor (SXR/PXR) in PCB-153 Metabolism and Protection against Associated Adverse Effects during Perinatal and Chronic Exposure in Mice. | 2020 Apr |
1 |
| 5 |
32848756 | The Clinical Impact of the C0/D Ratio and the CYP3A5 Genotype on Outcome in Tacrolimus Treated Kidney Transplant Recipients. | 2020 |
1 |
| 6 |
33076284 | Associations between Pregnane X Receptor and Breast Cancer Growth and Progression. | 2020 Oct 15 |
1 |
| 7 |
31008491 | [Role of pregnane X receptor (PXR) in endobiotic metabolism]. | 2019 Apr 25 |
1 |
| 8 |
29733390 | Increase in tacrolimus exposure after steroid tapering is influenced by CYP3A5 and pregnane X receptor genetic polymorphisms in renal transplant recipients. | 2018 Sep 1 |
1 |
| 9 |
27377607 | SXR rs3842689: a prognostic factor for steroid sensitivity or resistance in pediatric idiopathic nephrotic syndrome. | 2016 Jul |
2 |
| 10 |
27799961 | Heterozygous Inactivation of the Nuclear Receptor PXR/NR1I2 in a Patient With Anabolic Steroid-Induced Intrahepatic Cholestasis. | 2016 Aug |
3 |
| 11 |
25294580 | Pregnane X receptor as the "sensor and effector" in regulating epigenome. | 2015 Apr |
1 |
| 12 |
26408814 | Diethylstilbestrol-scaffold-based pregnane X receptor modulators. | 2015 Oct 20 |
3 |
| 13 |
22223399 | Affinity purification using recombinant PXR as a tool to characterize environmental ligands. | 2014 Feb |
2 |
| 14 |
24182399 | Molecular insights into the promiscuous interaction of human pregnane X receptor (hPXR) with diverse environmental chemicals and drug compounds. | 2014 Feb |
2 |
| 15 |
24828006 | Bazedoxifene-scaffold-based mimetics of solomonsterols A and B as novel pregnane X receptor antagonists. | 2014 Jun 12 |
1 |
| 16 |
23320515 | Global metabolomics and targeted steroid profiling reveal that rifampin, a strong human PXR activator, alters endogenous urinary steroid markers. | 2013 Mar 1 |
2 |
| 17 |
23384967 | Comparative analysis of human CYP3A4 and rat CYP3A1 induction and relevant gene expression by bisphenol A and diethylstilbestrol: implications for toxicity testing paradigms. | 2013 Jun |
1 |
| 18 |
23919967 | The tumor suppressor TERE1 (UBIAD1) prenyltransferase regulates the elevated cholesterol phenotype in castration resistant prostate cancer by controlling a program of ligand dependent SXR target genes. | 2013 Jul |
1 |
| 19 |
24025090 | Sulfotransferase genes: regulation by nuclear receptors in response to xeno/endo-biotics. | 2013 Nov |
1 |
| 20 |
22074953 | Evolutionary history and functional characterization of the amphibian xenosensor CAR. | 2012 Jan |
1 |
| 21 |
22285937 | 4-Methylenesterols from Theonella swinhoei sponge are natural pregnane-X-receptor agonists and farnesoid-X-receptor antagonists that modulate innate immunity. | 2012 Apr |
2 |
| 22 |
23000093 | Marine sponge steroids as nuclear receptor ligands. | 2012 Nov |
2 |
| 23 |
23007437 | Ligand- and structure-based pregnane X receptor models. | 2012 |
2 |
| 24 |
21291553 | The evolution of farnesoid X, vitamin D, and pregnane X receptors: insights from the green-spotted pufferfish (Tetraodon nigriviridis) and other non-mammalian species. | 2011 Feb 3 |
1 |
| 25 |
21295138 | Nuclear receptor PXR, transcriptional circuits and metabolic relevance. | 2011 Aug |
1 |
| 26 |
21428459 | Theonellasterols and conicasterols from Theonella swinhoei. Novel marine natural ligands for human nuclear receptors. | 2011 Apr 28 |
1 |
| 27 |
21742782 | Acetyl tributyl citrate, the most widely used phthalate substitute plasticizer, induces cytochrome p450 3a through steroid and xenobiotic receptor. | 2011 Oct |
3 |
| 28 |
21764778 | Liganded pregnane X receptor represses the human sulfotransferase SULT1E1 promoter through disrupting its chromatin structure. | 2011 Oct |
2 |
| 29 |
20024649 | Evaluation of an hPXR reporter gene assay for the detection of aquatic emerging pollutants: screening of chemicals and application to water samples. | 2010 Jan |
2 |
| 30 |
19240808 | The steroid and xenobiotic receptor (SXR), beyond xenobiotic metabolism. | 2009 |
5 |
| 31 |
19297428 | Human CYP3A4 and murine Cyp3A11 are regulated by equol and genistein via the pregnane X receptor in a species-specific manner. | 2009 May |
1 |
| 32 |
19702536 | The transcriptional regulation of the human CYP2C genes. | 2009 Jul |
1 |
| 33 |
19856963 | The structural basis of pregnane X receptor binding promiscuity. | 2009 Dec 8 |
2 |
| 34 |
20011107 | Challenges predicting ligand-receptor interactions of promiscuous proteins: the nuclear receptor PXR. | 2009 Dec |
3 |
| 35 |
20871735 | Activation of CAR and PXR by Dietary, Environmental and Occupational Chemicals Alters Drug Metabolism, Intermediary Metabolism, and Cell Proliferation. | 2009 Jun 1 |
2 |
| 36 |
18565212 | Human pregnane X receptor is expressed in breast carcinomas, potential heterodimers formation between hPXR and RXR-alpha. | 2008 Jun 19 |
2 |
| 37 |
18629309 | Activation of steroid and xenobiotic receptor (SXR, NR1I2) and its orthologs in laboratory, toxicologic, and genome model species. | 2008 Jul |
3 |
| 38 |
19018724 | PXR: a xenobiotic receptor of diverse function implicated in pharmacogenetics. | 2008 Nov |
1 |
| 39 |
17088262 | PXR induces CYP27A1 and regulates cholesterol metabolism in the intestine. | 2007 Feb |
2 |
| 40 |
17327420 | Crystal structure of the pregnane X receptor-estradiol complex provides insights into endobiotic recognition. | 2007 May |
2 |
| 41 |
17576789 | Human pregnane X receptor antagonists and agonists define molecular requirements for different binding sites. | 2007 Sep |
1 |
| 42 |
17636047 | Down-regulation of pregnane X receptor contributes to cell growth inhibition and apoptosis by anticancer agents in endometrial cancer cells. | 2007 Oct |
4 |
| 43 |
17298222 | (Far) Outside the box: genomic approach to acute porphyria. | 2006 |
1 |
| 44 |
17526937 | Tamoxifen activates CYP3A4 and MDR1 genes through steroid and xenobiotic receptor in breast cancer cells. | 2006 Dec |
1 |
| 45 |
15331348 | Mechanism of rifampicin and pregnane X receptor inhibition of human cholesterol 7 alpha-hydroxylase gene transcription. | 2005 Jan |
6 |
| 46 |
15650019 | The pregnane X receptor regulates gene expression in a ligand- and promoter-selective fashion. | 2005 May |
2 |
| 47 |
15713537 | Steroid and xenobiotic receptor (SXR), cytochrome P450 3A4 and multidrug resistance gene 1 in human adult and fetal tissues. | 2005 Feb 28 |
1 |
| 48 |
15832810 | Induction of phase I, II and III drug metabolism/transport by xenobiotics. | 2005 Mar |
3 |
| 49 |
15885729 | Lignans, bacteriocides and organochlorine compounds activate the human pregnane X receptor (PXR). | 2005 Dec 1 |
4 |
| 50 |
16054614 | CAR and PXR: xenosensors of endocrine disrupters? | 2005 Aug 15 |
3 |