sapropterin

nitric oxide synthase 3 ; Homo sapiens







102 Article(s)
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51 20184376 Peroxynitrite induces destruction of the tetrahydrobiopterin and heme in endothelial nitric oxide synthase: transition from reversible to irreversible enzyme inhibition. 2010 Apr 13 1
52 20858749 Homocysteine impairs coronary artery endothelial function by inhibiting tetrahydrobiopterin in patients with hyperhomocysteinemia. 2010 Dec 1
53 21147698 [Nitric oxide and preeclampsia]. 2010 Dec 26 1
54 21179168 S-glutathionylation uncouples eNOS and regulates its cellular and vascular function. 2010 Dec 23 1
55 21188246 The role of tetrahydrobiopterin and dihydrobiopterin in ischemia/reperfusion injury when given at reperfusion. 2010 2
56 18849028 L-arginine and tetrahydrobiopterin protects against ischemia/reperfusion-induced endothelial dysfunction in patients with type 2 diabetes mellitus and coronary artery disease. 2009 May 1
57 19011239 Quantitative regulation of intracellular endothelial nitric-oxide synthase (eNOS) coupling by both tetrahydrobiopterin-eNOS stoichiometry and biopterin redox status: insights from cells with tet-regulated GTP cyclohydrolase I expression. 2009 Jan 9 21
58 19286667 Tetrahydrobiopterin recycling, a key determinant of endothelial nitric-oxide synthase-dependent signaling pathways in cultured vascular endothelial cells. 2009 May 8 1
59 19447893 GTP cyclohydrolase I expression is regulated by nitric oxide: role of cyclic AMP. 2009 Aug 1
60 19666465 Critical role for tetrahydrobiopterin recycling by dihydrofolate reductase in regulation of endothelial nitric-oxide synthase coupling: relative importance of the de novo biopterin synthesis versus salvage pathways. 2009 Oct 9 2
61 19797052 Active NF-E2-related factor (Nrf2) contributes to keep endothelial NO synthase (eNOS) in the coupled state: role of reactive oxygen species (ROS), eNOS, and heme oxygenase (HO-1) levels. 2009 Nov 13 2
62 17274989 TAT-BH4 counteracts Abeta toxicity on capillary endothelium. 2007 Feb 20 1
63 17293058 High-dose folate may improve platelet function in acute coronary syndrome and other pathologies associated with increased platelet oxidative stress. 2007 4
64 17413035 (6R)-5,6,7,8-tetrahydro-L-biopterin and its stereoisomer prevent ischemia reperfusion injury in human forearm. 2007 Jun 2
65 17420345 Global improvement of vascular function and redox state with low-dose folic acid: implications for folate therapy in patients with coronary artery disease. 2007 May 1 1
66 17486142 Nitric oxide homeostasis as a target for drug additives to cardioplegia. 2007 Aug 2
67 17698846 Oxygen metabolism by endothelial nitric-oxide synthase. 2007 Sep 28 1
68 17825498 Gamma-tocopherol may promote effective no synthase function by protecting tetrahydrobiopterin from peroxynitrite. 2007 2
69 17888559 Hydrogen sulfide inhibits activity of three isoforms of recombinant nitric oxide synthase. 2007 Nov 20 1
70 18040031 Altered plasma versus vascular biopterins in human atherosclerosis reveal relationships between endothelial nitric oxide synthase coupling, endothelial function, and inflammation. 2007 Dec 11 2
71 16585403 Endothelial nitric oxide synthase in vascular disease: from marvel to menace. 2006 Apr 4 6
72 16696853 A yeast 2-hybrid analysis of human GTP cyclohydrolase I protein interactions. 2006 Jun 2
73 15933248 Mechanisms of inducible nitric oxide synthase-mediated vascular dysfunction. 2005 Aug 2
74 15941833 Endothelial dihydrofolate reductase: critical for nitric oxide bioavailability and role in angiotensin II uncoupling of endothelial nitric oxide synthase. 2005 Jun 21 1
75 16234629 The clinical significance of endothelial dysfunction. 2005 Nov 2
76 14656731 Regulation of endothelial nitric oxide synthase by tetrahydrobiopterin in vascular disease. 2004 Mar 1
77 15166218 Three different oxygen-induced radical species in endothelial nitric-oxide synthase oxygenase domain under regulation by L-arginine and tetrahydrobiopterin. 2004 Jul 30 1
78 15256611 Coenzyme Q10 and diabetic endotheliopathy: oxidative stress and the 'recoupling hypothesis'. 2004 Aug 2
79 15288120 Alpha-tocopherol amplifies phosphorylation of endothelial nitric oxide synthase at serine 1177 and its short-chain derivative trolox stabilizes tetrahydrobiopterin. 2004 Sep 1 2
80 12586536 Functional characterization of Glu298Asp mutant human endothelial nitric oxide synthase purified from a yeast expression system. 2003 Feb 1
81 12692136 Interactions of peroxynitrite, tetrahydrobiopterin, ascorbic acid, and thiols: implications for uncoupling endothelial nitric-oxide synthase. 2003 Jun 20 3
82 12707237 Reactive oxygen species are involved in smoking-induced dysfunction of nitric oxide biosynthesis and upregulation of endothelial nitric oxide synthase: an in vitro demonstration in human coronary artery endothelial cells. 2003 May 13 1
83 12730050 Tetrahydrobiopterin restores endothelial dysfunction induced by an oral glucose challenge in healthy subjects. 2003 Aug 4
84 11812265 Nitric oxide therapies in vascular diseases. 2002 1
85 11870235 Chemical stabilization of tetrahydrobiopterin by L-ascorbic acid: contribution to placental endothelial nitric oxide synthase activity. 2002 Mar 1
86 11879202 The ratio between tetrahydrobiopterin and oxidized tetrahydrobiopterin analogues controls superoxide release from endothelial nitric oxide synthase: an EPR spin trapping study. 2002 Mar 15 4
87 11921705 [Role of tetrahydrobiopterin in the regulation of activity of human placental nitric oxide synthase in normal and pre-eclamptic pregnancies]. 2002 Feb 24 5
88 12176133 GTP cyclohydrolase I gene transfer augments intracellular tetrahydrobiopterin in human endothelial cells: effects on nitric oxide synthase activity, protein levels and dimerisation. 2002 Sep 10
89 11243424 Effect of vitamin C on the availability of tetrahydrobiopterin in human endothelial cells. 2001 Mar 3
90 11356602 Tetrahydrobiopterin: a critical cofactor for eNOS and a strategy in the treatment of endothelial dysfunction? 2001 Jun 1
91 11095925 Regulation of nitric oxide synthase activity by tetrahydrobiopterin in human placentae from normal and pre-eclamptic pregnancies. 2000 Nov 1
92 9914865 Effects of cytokines on nitric oxide pathways in human vasculature. 1999 Jan 1
93 10608822 Characterization of recombinant human endothelial nitric-oxide synthase purified from the yeast Pichia pastoris. 1999 Dec 31 1
94 9689061 Superoxide generation by endothelial nitric oxide synthase: the influence of cofactors. 1998 Aug 4 3
95 9748253 Superoxide generation from endothelial nitric-oxide synthase. A Ca2+/calmodulin-dependent and tetrahydrobiopterin regulatory process. 1998 Oct 2 3
96 9857005 The C331A mutant of neuronal nitric-oxide synthase is defective in arginine binding. 1998 Dec 25 2
97 9872368 Differential response of basal and tetrahydrobiopterin-stimulated activities of placental type III nitric oxide synthase to sodium dodecyl sulphate: relation to dimeric structure. 1998 Dec 5
98 9089781 Activation and dimerization of type III nitric oxide synthase by submicromolar concentrations of tetrahydrobiopterin in microsomal preparations from human primordial placenta. 1997 Mar-Apr 2
99 9237256 Tetrahydrobiopterin preferentially stimulates activity and promotes subunit aggregation of membrane-bound calcium-dependent nitric oxide synthase in human placenta. 1997 Apr 5
100 9268712 Tetrahydrobiopterin regulates superoxide and nitric oxide generation by recombinant endothelial nitric oxide synthase. 1997 Aug 18 4