| 1 |
33909501 | The effect of young and old ex vivo human serum on cellular protein synthesis and growth in an in vitro model of aging. | 2021 Jul 1 |
1 |
| 2 |
34323596 | Dileucine ingestion is more effective than leucine in stimulating muscle protein turnover in young males: a double blind randomized controlled trial. | 2021 Sep 1 |
1 |
| 3 |
34367129 | L-Leucine Promotes STAT1 and ISGs Expression in TGEV-Infected IPEC-J2 Cells via mTOR Activation. | 2021 |
1 |
| 4 |
30761631 | Leucine-induced promotion of post-absorptive EAA utilization and hepatic gluconeogenesis contributes to protein synthesis in skeletal muscle of dairy calves. | 2019 May |
1 |
| 5 |
30900779 | Regulation of the expression of key signalling molecules in mTOR pathway of skeletal muscle satellite cells in neonatal chicks: Effects of leucine and glycine-leucine peptide. | 2019 May |
1 |
| 6 |
28856713 | Leucine supplementation after mechanical stimulation activates protein synthesis via L-type amino acid transporter 1 in vitro. | 2018 Feb |
4 |
| 7 |
30054913 | The muscle anabolic effect of protein ingestion during a hyperinsulinaemic euglycaemic clamp in middle-aged women is not caused by leucine alone. | 2018 Oct |
4 |
| 8 |
30175263 | L-leucine stimulates glutamate dehydrogenase activity and glutamate synthesis by regulating mTORC1/SIRT4 pathway in pig liver. | 2018 Sep |
1 |
| 9 |
26724922 | Structure-activity relations of leucine derivatives reveal critical moieties for cellular uptake and activation of mTORC1-mediated signaling. | 2016 Apr |
3 |
| 10 |
27144582 | Hypertrophy-Promoting Effects of Leucine Supplementation and Moderate Intensity Aerobic Exercise in Pre-Senescent Mice. | 2016 May 2 |
1 |
| 11 |
25553480 | Nutritional and regulatory roles of leucine in muscle growth and fat reduction. | 2015 Jan 1 |
1 |
| 12 |
25971373 | Mechanical stretch activates mammalian target of rapamycin and AMP-activated protein kinase pathways in skeletal muscle cells. | 2015 Aug |
1 |
| 13 |
26169935 | Leucine does not affect mechanistic target of rapamycin complex 1 assembly but is required for maximal ribosomal protein s6 kinase 1 activity in human skeletal muscle following resistance exercise. | 2015 Oct |
2 |
| 14 |
29767001 | Effects of dietary leucine supplementation on the gene expression of mammalian target of rapamycin signaling pathway and intestinal development of broilers. | 2015 Dec |
1 |
| 15 |
23783244 | Acute uremia suppresses leucine-induced signal transduction in skeletal muscle. | 2014 Feb |
1 |
| 16 |
24476474 | Absence of leucine in an essential amino acid supplement reduces activation of mTORC1 signalling following resistance exercise in young females. | 2014 Feb |
2 |
| 17 |
25107987 | Dose-dependent increases in p70S6K phosphorylation and intramuscular branched-chain amino acids in older men following resistance exercise and protein intake. | 2014 Aug 1 |
1 |
| 18 |
22898570 | Cellular signaling of amino acids towards mTORC1 activation in impaired human leucine catabolism. | 2013 May |
1 |
| 19 |
23129808 | Novel role for SHP-2 in nutrient-responsive control of S6 kinase 1 signaling. | 2013 Jan |
3 |
| 20 |
22391631 | Enteral leucine supplementation increases protein synthesis in skeletal and cardiac muscles and visceral tissues of neonatal pigs through mTORC1-dependent pathways. | 2012 Apr |
1 |
| 21 |
22442136 | Rag GTPases and AMPK/TSC2/Rheb mediate the differential regulation of mTORC1 signaling in response to alcohol and leucine. | 2012 May 15 |
1 |
| 22 |
22523661 | Excessive Leucine-mTORC1-Signalling of Cow Milk-Based Infant Formula: The Missing Link to Understand Early Childhood Obesity. | 2012 |
1 |
| 23 |
20558053 | Leucine supplementation in rats induced a delay in muscle IR/PI3K signaling pathway associated with overall impaired glucose tolerance. | 2011 Mar |
2 |
| 24 |
21282364 | Leucine deprivation increases hepatic insulin sensitivity via GCN2/mTOR/S6K1 and AMPK pathways. | 2011 Mar |
2 |
| 25 |
21698202 | ER stress induces anabolic resistance in muscle cells through PKB-induced blockade of mTORC1. | 2011 |
2 |
| 26 |
21702994 | The actions of exogenous leucine on mTOR signalling and amino acid transporters in human myotubes. | 2011 Jun 25 |
1 |
| 27 |
21906315 | Upstream molecular signaling pathways of p27(Kip1) expression in human breast cancer cells in vitro: differential effects of 4-hydroxytamoxifen and deficiency of either D-(+)-glucose or L-leucine. | 2011 Sep 9 |
1 |
| 28 |
19940100 | Leucine modulates contraction- and insulin-stimulated glucose transport and upstream signaling events in rat skeletal muscle. | 2010 Feb |
1 |
| 29 |
20051528 | Activation of the cardiac mTOR/p70(S6K) pathway by leucine requires PDK1 and correlates with PRAS40 phosphorylation. | 2010 Apr |
7 |
| 30 |
20298436 | Role of N-end rule ubiquitin ligases UBR1 and UBR2 in regulating the leucine-mTOR signaling pathway. | 2010 Apr 1 |
1 |
| 31 |
20473536 | Supplementing L-leucine to a low-protein diet increases tissue protein synthesis in weanling pigs. | 2010 Nov |
1 |
| 32 |
20682696 | Downregulation of AMPK accompanies leucine- and glucose-induced increases in protein synthesis and insulin resistance in rat skeletal muscle. | 2010 Oct |
2 |
| 33 |
19266162 | Post-transcriptional gene silencing of ribosomal protein S6 kinase 1 restores insulin action in leucine-treated skeletal muscle. | 2009 Apr |
2 |
| 34 |
18435829 | Leucine induces phosphorylation and activation of p70S6K in cortical neurons via the system L amino acid transporter. | 2008 Jul |
2 |
| 35 |
17505052 | Regulation of muscle protein synthesis during sepsis and inflammation. | 2007 Aug |
1 |
| 36 |
14560955 | TOR action in mammalian cells and in Caenorhabditis elegans. | 2004 |
1 |
| 37 |
14684182 | mTOR integrates amino acid- and energy-sensing pathways. | 2004 Jan 9 |
1 |
| 38 |
15228219 | Tissue-specific regulation of 4E-BP1 and S6K1 phosphorylation by alpha-ketoisocaproate. | 2004 Feb |
4 |
| 39 |
12611592 | Regulation of targets of mTOR (mammalian target of rapamycin) signalling by intracellular amino acid availability. | 2003 Jun 1 |
1 |
| 40 |
12681504 | Amino acid availability regulates S6K1 and protein synthesis in avian insulin-insensitive QM7 myoblasts. | 2003 Apr 10 |
1 |
| 41 |
12812918 | Potential role of leucine metabolism in the leucine-signaling pathway involving mTOR. | 2003 Oct |
1 |
| 42 |
19079937 | Leucine: a key amino acid in ageing-associated sarcopenia? | 2003 Jun |
1 |
| 43 |
12023960 | Molecular basis for the substrate specificity of NIMA-related kinase-6 (NEK6). Evidence that NEK6 does not phosphorylate the hydrophobic motif of ribosomal S6 protein kinase and serum- and glucocorticoid-induced protein kinase in vivo. | 2002 Aug 2 |
1 |
| 44 |
11238774 | Signaling pathways involved in translational control of protein synthesis in skeletal muscle by leucine. | 2001 Mar |
1 |
| 45 |
11272147 | Metabolic regulation by leucine of translation initiation through the mTOR-signaling pathway by pancreatic beta-cells. | 2001 Feb |
4 |
| 46 |
11500301 | Leucine and insulin activate p70 S6 kinase through different pathways in human skeletal muscle. | 2001 Sep |
4 |
| 47 |
10206976 | Leucine regulates translation of specific mRNAs in L6 myoblasts through mTOR-mediated changes in availability of eIF4E and phosphorylation of ribosomal protein S6. | 1999 Apr 23 |
1 |