Leucine

CREB regulated transcription coactivator 1 ; Mus musculus







133 Article(s)
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51 29283439 Homozygous boricua TBCK mutation causes neurodegeneration and aberrant autophagy. 2018 Jan 1
52 29422900 Role of SLC7A5 in Metabolic Reprogramming of Human Monocyte/Macrophage Immune Responses. 2018 1
53 29574525 The putative leucine sensor Sestrin2 is hyperphosphorylated by acute resistance exercise but not protein ingestion in human skeletal muscle. 2018 Jun 1
54 29728917 Short- and long-term effects of leucine and branched-chain amino acid supplementation of a protein- and energy-reduced diet on muscle protein metabolism in neonatal pigs. 2018 Jul 1
55 29784813 Coordination of the leucine-sensing Rag GTPase cycle by leucyl-tRNA synthetase in the mTORC1 signaling pathway. 2018 Jun 5 2
56 29844341 Leucine/glutamine and v-ATPase/lysosomal acidification via mTORC1 activation are required for position-dependent regeneration. 2018 May 29 2
57 30029003 Translational Control through Differential Ribosome Pausing during Amino Acid Limitation in Mammalian Cells. 2018 Jul 19 1
58 30041947 Discovery of novel leucyladenylate sulfamate surrogates as leucyl-tRNA synthetase (LRS)-targeted mammalian target of rapamycin complex 1 (mTORC1) inhibitors. 2018 Aug 7 1
59 30175263 L-leucine stimulates glutamate dehydrogenase activity and glutamate synthesis by regulating mTORC1/SIRT4 pathway in pig liver. 2018 Sep 3
60 30282607 Proteomic analyses reveal GNG12 regulates cell growth and casein synthesis by activating the Leu-mediated mTORC1 signaling pathway. 2018 Nov 3
61 27988363 In vitro antiglioma action of indomethacin is mediated via AMP-activated protein kinase/mTOR complex 1 signalling pathway. 2017 Feb 2
62 28409828 Leucine elicits myotube hypertrophy and enhances maximal contractile force in tissue engineered skeletal muscle in vitro. 2017 Oct 1
63 28588499 Intake of a Ketone Ester Drink during Recovery from Exercise Promotes mTORC1 Signaling but Not Glycogen Resynthesis in Human Muscle. 2017 1
64 28626421 Divergent Metabolic Regulation of Autophagy and mTORC1-Early Events in Alzheimer's Disease? 2017 1
65 28731988 Roles of Mitogen-Activating Protein Kinase Kinase Kinase Kinase-3 (MAP4K3) in Preterm Skeletal Muscle Satellite Cell Myogenesis and Mammalian Target of Rapamycin Complex 1 (mTORC1) Activation Regulation. 2017 Jul 21 2
66 28882589 Leucine-induced localization of Leucyl-tRNA synthetase in lysosome membrane. 2017 Nov 18 1
67 28963468 Control of leucine-dependent mTORC1 pathway through chemical intervention of leucyl-tRNA synthetase and RagD interaction. 2017 Sep 29 4
68 29053970 mTORC1 Activator SLC38A9 Is Required to Efflux Essential Amino Acids from Lysosomes and Use Protein as a Nutrient. 2017 Oct 19 2
69 29296509 Amino acid and small GTPase regulation of mTORC1. 2017 1
70 26449471 Sestrin2 is a leucine sensor for the mTORC1 pathway. 2016 Jan 1 6
71 26586190 Structural basis for leucine sensing by the Sestrin2-mTORC1 pathway. 2016 Jan 1 3
72 26645537 Leucine supplementation is anti-atrophic during paradoxical sleep deprivation in rats. 2016 Apr 2
73 26724922 Structure-activity relations of leucine derivatives reveal critical moieties for cellular uptake and activation of mTORC1-mediated signaling. 2016 Apr 7
74 26729373 Improved transcription and translation with L-leucine stimulation of mTORC1 in Roberts syndrome. 2016 Jan 5 2
75 26836250 Maternal diabetes promotes mTORC1 downstream signalling in rabbit preimplantation embryos. 2016 May 2
76 26884386 Pulsatile delivery of a leucine supplement during long-term continuous enteral feeding enhances lean growth in term neonatal pigs. 2016 Apr 15 2
77 26959180 Toward a Molecular Definition of Leucine-Dependent mTORC1 Activation. 2016 Mar 8 1
78 27010498 Leucine induced dephosphorylation of Sestrin2 promotes mTORC1 activation. 2016 Aug 6
79 27053525 Activation of mTORC1 by leucine is potentiated by branched-chain amino acids and even more so by essential amino acids following resistance exercise. 2016 Jun 1 2
80 27209231 Discovery of (S)-4-isobutyloxazolidin-2-one as a novel leucyl-tRNA synthetase (LRS)-targeted mTORC1 inhibitor. 2016 Jul 1 1
81 27245337 Intake of branched-chain or essential amino acids attenuates the elevation in muscle levels of PGC-1α4 mRNA caused by resistance exercise. 2016 Jul 1 1
82 27280402 FLCN Maintains the Leucine Level in Lysosome to Stimulate mTORC1. 2016 1
83 27297692 GCN2 contributes to mTORC1 inhibition by leucine deprivation through an ATF4 independent mechanism. 2016 Jun 14 2
84 27422517 Leucine Metabolism in T Cell Activation: mTOR Signaling and Beyond. 2016 Jul 1
85 27477288 Leucyl-tRNA Synthetase Activates Vps34 in Amino Acid-Sensing mTORC1 Signaling. 2016 Aug 9 1
86 27649739 The apo-structure of the leucine sensor Sestrin2 is still elusive. 2016 Sep 20 5
87 27690010 Recent Advances in Understanding Amino Acid Sensing Mechanisms that Regulate mTORC1. 2016 Sep 29 1
88 27933890 Discovery of Leucyladenylate Sulfamates as Novel Leucyl-tRNA Synthetase (LRS)-Targeted Mammalian Target of Rapamycin Complex 1 (mTORC1) Inhibitors. 2016 Nov 23 1
89 27934653 Leucine and Mammalian Target of Rapamycin-Dependent Activation of Muscle Protein Synthesis in Aging. 2016 Dec 1
90 25567907 Metabolism. Differential regulation of mTORC1 by leucine and glutamine. 2015 Jan 9 1
91 25774780 High-fat feeding impairs nutrient sensing and gut brain integration in the caudomedial nucleus of the solitary tract in mice. 2015 1
92 25872869 The mTORC1/4E-BP pathway coordinates hemoglobin production with L-leucine availability. 2015 Apr 14 2
93 25998567 LAPTM4b recruits the LAT1-4F2hc Leu transporter to lysosomes and promotes mTORC1 activation. 2015 May 22 2
94 26007333 Leucine Promotes Proliferation and Differentiation of Primary Preterm Rat Satellite Cells in Part through mTORC1 Signaling Pathway. 2015 May 8 1
95 26169935 Leucine does not affect mechanistic target of rapamycin complex 1 assembly but is required for maximal ribosomal protein s6 kinase 1 activity in human skeletal muscle following resistance exercise. 2015 Oct 2
96 27021048 [Role of the mTOR pathway in the central regulation of energy balance]. 2015 1
97 24284439 Role of amino acid transporters in amino acid sensing. 2014 Jan 1
98 24476474 Absence of leucine in an essential amino acid supplement reduces activation of mTORC1 signalling following resistance exercise in young females. 2014 Feb 3
99 24722568 Leucyl-tRNA synthetase regulates lactation and cell proliferation via mTOR signaling in dairy cow mammary epithelial cells. 2014 Apr 9 1
100 24740400 Ursolic acid inhibits leucine-stimulated mTORC1 signaling by suppressing mTOR localization to lysosome. 2014 2