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34714145 | mTOR1c Activation with the Leucine "Trigger" for Prevention of Sarcopenia in Older Adults During Lockdown. | 2022 Feb |
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34862201 | Nutrient Sensor mTORC1 Regulates Insulin Secretion by Modulating β-Cell Autophagy. | 2022 Mar 1 |
2 |
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35022234 | GATOR2 complex-mediated amino acid signaling regulates brain myelination. | 2022 Jan 18 |
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| 4 |
35114100 | E3 ligase RNF167 and deubiquitinase STAMBPL1 modulate mTOR and cancer progression. | 2022 Feb 17 |
2 |
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35334826 | Mild Endurance Exercise during Fasting Increases Gastrocnemius Muscle and Prefrontal Cortex Thyroid Hormone Levels through Differential BHB and BCAA-Mediated BDNF-mTOR Signaling in Rats. | 2022 Mar 10 |
1 |
| 6 |
35457142 | Role of Branched-Chain Amino Acid Metabolism in Type 2 Diabetes, Obesity, Cardiovascular Disease and Non-Alcoholic Fatty Liver Disease. | 2022 Apr 13 |
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| 7 |
35577075 | Prolonged deprivation of arginine or leucine induces PI3K/Akt-dependent reactivation of mTORC1. | 2022 May 13 |
5 |
| 8 |
35614056 | O-GlcNAc modification of leucyl-tRNA synthetase 1 integrates leucine and glucose availability to regulate mTORC1 and the metabolic fate of leucine. | 2022 May 25 |
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33285244 | REV-ERBα alters circadian rhythms by modulating mTOR signaling. | 2021 Feb 5 |
7 |
| 10 |
33863987 | Leucyl-tRNA synthetase deficiency systemically induces excessive autophagy in zebrafish. | 2021 Apr 16 |
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| 11 |
33883257 | Amino acids and RagD potentiate mTORC1 activation in CD8+ T cells to confer antitumor immunity. | 2021 Apr |
3 |
| 12 |
33910001 | Leucine-sensing mechanism of leucyl-tRNA synthetase 1 for mTORC1 activation. | 2021 Apr 27 |
4 |
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33979735 | Structure-based modification of pyrazolone derivatives to inhibit mTORC1 by targeting the leucyl-tRNA synthetase-RagD interaction. | 2021 Jul |
1 |
| 14 |
34016143 | Interactions among mTORC, AMPK and SIRT: a computational model for cell energy balance and metabolism. | 2021 May 20 |
1 |
| 15 |
34075648 | Glutaminolysis is involved in the activation of mTORC1 in in vitro-produced porcine embryos. | 2021 Jul |
1 |
| 16 |
34118944 | Effect of the lysosomotropic agent chloroquine on mTORC1 activation and protein synthesis in human skeletal muscle. | 2021 Jun 12 |
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| 17 |
34126555 | The involvement of Sestrin2 in the effect of IGF-I and leucine on mTROC1 activity in C2C12 and L6 myocytes. | 2021 Aug |
6 |
| 18 |
34198993 | Amino Acid-Mediated Intracellular Ca2+ Rise Modulates mTORC1 by Regulating the TSC2-Rheb Axis through Ca2+/Calmodulin. | 2021 Jun 27 |
3 |
| 19 |
34258600 | Protocol for improving diffraction quality of leucyl-tRNA synthetase 1 with methylation and post-crystallization soaking and cooling in cryoprotectants. | 2021 Sep 17 |
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| 20 |
34290409 | SAR1B senses leucine levels to regulate mTORC1 signalling. | 2021 Aug |
5 |
| 21 |
34323596 | Dileucine ingestion is more effective than leucine in stimulating muscle protein turnover in young males: a double blind randomized controlled trial. | 2021 Sep 1 |
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| 22 |
34325132 | Leucyl-tRNA synthetase 1 is required for proliferation of TSC-null cells. | 2021 Sep 24 |
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| 23 |
34343656 | Dioscin ameliorates murine ulcerative colitis by regulating macrophage polarization. | 2021 Oct |
1 |
| 24 |
34503187 | Targeting Amino Acid Metabolic Reprogramming via L-Type Amino Acid Transporter 1 (LAT1) for Endocrine-Resistant Breast Cancer. | 2021 Aug 30 |
1 |
| 25 |
34572527 | Insights into the Interaction of Lysosomal Amino Acid Transporters SLC38A9 and SLC36A1 Involved in mTORC1 Signaling in C2C12 Cells. | 2021 Sep 6 |
1 |
| 26 |
34610328 | Monomethyl branched-chain fatty acid mediates amino acid sensing upstream of mTORC1. | 2021 Oct 11 |
1 |
| 27 |
31924757 | PHD1 controls muscle mTORC1 in a hydroxylation-independent manner by stabilizing leucyl tRNA synthetase. | 2020 Jan 10 |
3 |
| 28 |
32019866 | Glutamine and asparagine activate mTORC1 independently of Rag GTPases. | 2020 Mar 6 |
1 |
| 29 |
32232361 | Molecular basis of the multifaceted functions of human leucyl-tRNA synthetase in protein synthesis and beyond. | 2020 May 21 |
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| 30 |
32297642 | Leucine and branched-chain amino acid metabolism contribute to the growth of bone sarcomas by regulating AMPK and mTORC1 signaling. | 2020 May 15 |
1 |
| 31 |
32561715 | Leucine regulates autophagy via acetylation of the mTORC1 component raptor. | 2020 Jun 19 |
4 |
| 32 |
32620110 | AIMTOR, a BRET biosensor for live imaging, reveals subcellular mTOR signaling and dysfunctions. | 2020 Jul 3 |
1 |
| 33 |
32799865 | Amino acid-dependent control of mTORC1 signaling: a variety of regulatory modes. | 2020 Aug 17 |
1 |
| 34 |
33127851 | CREB Coactivator CRTC2 Plays a Crucial Role in Endothelial Function. | 2020 Dec 2 |
1 |
| 35 |
33222863 | Insulin potentiates essential amino acids effects on mechanistic target of rapamycin complex 1 signaling in MAC-T cells. | 2020 Dec |
1 |
| 36 |
30092695 | l-Leucine influx through Slc7a5 regulates inflammatory responses of human B cells via mammalian target of rapamycin complex 1 signaling. | 2019 Sep |
2 |
| 37 |
30197302 | Leucine Signals to mTORC1 via Its Metabolite Acetyl-Coenzyme A. | 2019 Jan 8 |
8 |
| 38 |
30696773 | Interleukin-18 up-regulates amino acid transporters and facilitates amino acid-induced mTORC1 activation in natural killer cells. | 2019 Mar 22 |
3 |
| 39 |
30835510 | Evidence for a role for Sestrin1 in mediating leucine-induced activation of mTORC1 in skeletal muscle. | 2019 May 1 |
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| 40 |
30844724 | Recent advances in understanding of amino acid signaling to mTORC1 activation. | 2019 Mar 1 |
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| 41 |
30858438 | Discovery of NV-5138, the first selective Brain mTORC1 activator. | 2019 Mar 11 |
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| 42 |
30990795 | Sestrin modulator NV-5138 produces rapid antidepressant effects via direct mTORC1 activation. | 2019 Apr 16 |
1 |
| 43 |
31067471 | The Ion Transporter NKCC1 Links Cell Volume to Cell Mass Regulation by Suppressing mTORC1. | 2019 May 7 |
1 |
| 44 |
31107245 | NV-5138 as a fast-acting antidepressant via direct activation of mTORC1 signaling. | 2019 May 20 |
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| 45 |
31134526 | ATP6V0d2 mediates leucine-induced mTORC1 activation and polarization of macrophages. | 2019 Aug |
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| 46 |
31345230 | EGF-activated PI3K/Akt signalling coordinates leucine uptake by regulating LAT3 expression in prostate cancer. | 2019 Jul 25 |
2 |
| 47 |
31379141 | Sensors for the mTORC1 pathway regulated by amino acids. | 2019 Sept. |
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| 48 |
31668641 | Amino Acids License Kinase mTORC1 Activity and Treg Cell Function via Small G Proteins Rag and Rheb. | 2019 Dec 17 |
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| 49 |
29150487 | Dynamin inhibitors block activation of mTORC1 by amino acids independently of dynamin. | 2018 Jan 4 |
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| 50 |
29278758 | Leucine reduces the proliferation of MC3T3-E1 cells through DNA damage and cell senescence. | 2018 Apr |
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