ponatinib

mechanistic target of rapamycin kinase ; Homo sapiens







8 Article(s)
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1 35603651 [Ponatinib inhibits the proliferation of SNU-449 human hepatocellular cancer cells and blocks MAPK and PDK1/AKT/mTOR signaling pathways]. 2022 May 3
2 33452624 Combating TKI resistance in CML by inhibiting the PI3K/Akt/mTOR pathway in combination with TKIs: a review. 2021 Jan 16 1
3 34461124 PI3K/mTOR dual-inhibition with VS-5584 enhances anti-leukemic efficacy of ponatinib in blasts and Ph-negative LSCs of chronic myeloid leukemia. 2021 Nov 5 2
4 30959969 Ponatinib Inhibits Proliferation and Induces Apoptosis of Liver Cancer Cells, but Its Efficacy Is Compromised by Its Activation on PDK1/Akt/mTOR Signaling. 2019 Apr 7 3
5 29165716 Targeting BCR-ABL-Independent TKI Resistance in Chronic Myeloid Leukemia by mTOR and Autophagy Inhibition. 2018 May 1 1
6 26206305 Identifying kinase dependency in cancer cells by integrating high-throughput drug screening and kinase inhibition data. 2015 Dec 1 1
7 26359452 Kinome RNAi Screens Reveal Synergistic Targeting of MTOR and FGFR1 Pathways for Treatment of Lung Cancer and HNSCC. 2015 Oct 15 1
8 23468082 Combined targeting of FGFR2 and mTOR by ponatinib and ridaforolimus results in synergistic antitumor activity in FGFR2 mutant endometrial cancer models. 2013 May 2