Lactic Acid

mechanistic target of rapamycin kinase ; Homo sapiens







37 Article(s)
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1 34724274 Targeting lactate metabolism and glycolytic pathways in the tumor microenvironment by natural products: A promising strategy in combating cancer. 2022 Mar 1
2 34973450 Upregulated hexokinase 2 expression induces the apoptosis of dopaminergic neurons by promoting lactate production in Parkinson's disease. 2022 Feb 2
3 35069879 CRNDE silencing promotes apoptosis and enhances cisplatin sensitivity of colorectal carcinoma cells by inhibiting the Akt/mTORC1-mediated Warburg effect. 2022 Feb 1
4 35589065 Lactate inhibits osteogenic differentiation of human periodontal ligament stem cells via autophagy through the MCT1-mTOR signaling pathway. 2022 May 16 2
5 32878490 Holothuria scabra Extract Induces Cell Apoptosis and Suppresses Warburg Effect by Down-Regulating Akt/mTOR/HIF-1 Axis in MDA-MB-231 Breast Cancer Cells. 2021 1
6 34656878 Lactate in the tumour microenvironment: From immune modulation to therapy. 2021 Nov 2
7 34746839 Effect of lactate administration on mouse skeletal muscle under calorie restriction. 2021 2
8 32698682 Acute effects of lactic acid-fermented and enzyme-digested soybean on protein synthesis via mTOR signaling in the skeletal muscle. 2020 Nov 1
9 32917658 Lactate-Modulated Immunosuppression of Myeloid-Derived Suppressor Cells Contributes to the Radioresistance of Pancreatic Cancer. 2020 Nov 2
10 32985258 The effects and mechanisms of isoliquiritigenin loaded nanoliposomes regulated AMPK/mTOR mediated glycolysis in colorectal cancer. 2020 Dec 1
11 33013932 Regulation of RLR-Mediated Antiviral Responses of Human Dendritic Cells by mTOR. 2020 1
12 30670777 Effect of PTEN inactivating germline mutations on innate immune cell function and thyroid cancer-induced macrophages in patients with PTEN hamartoma tumor syndrome. 2019 May 1
13 30867812 Tumor-secreted dickkopf2 accelerates aerobic glycolysis and promotes angiogenesis in colorectal cancer. 2019 1
14 30871777 Fubp1 supports the lactate-Akt-mTOR axis through the upregulation of Hk1 and Hk2. 2019 Apr 23 2
15 30881132 Construction of a GLUT-1 and HIF-1α gene knockout cell model in HEp-2 cells using the CRISPR/Cas9 technique. 2019 1
16 31496162 [High dose vitamin C inhibits proliferation of breast cancer cells through reducing glycolysis and protein synthesis]. 2019 May 25 1
17 31798707 Macrophage transcriptome modification induced by hypoxia and lactate. 2019 Dec 1
18 29886375 Down-regulation of miR-214 inhibits proliferation and glycolysis in non-small-cell lung cancer cells via down-regulating the expression of hexokinase 2 and pyruvate kinase isozyme M2. 2018 Sep 1
19 29916308 The mTOR Pathway Regulates PKM2 to Affect Glycolysis in Esophageal Squamous Cell Carcinoma. 2018 Jan 1 1
20 28578659 Rapamycin (mTORC1 inhibitor) reduces the production of lactate and 2-hydroxyglutarate oncometabolites in IDH1 mutant fibrosarcoma cells. 2017 Jun 2 1
21 28624789 Pediatric and adult glioblastoma radiosensitization induced by PI3K/mTOR inhibition causes early metabolic alterations detected by nuclear magnetic resonance spectroscopy. 2017 Jul 18 1
22 28704425 In vitro nuclear magnetic resonance spectroscopy metabolic biomarkers for the combination of temozolomide with PI3K inhibition in paediatric glioblastoma cells. 2017 1
23 28731193 Promotion of glycolysis by HOTAIR through GLUT1 upregulation via mTOR signaling. 2017 Sep 2
24 27050525 ERRα-Regulated Lactate Metabolism Contributes to Resistance to Targeted Therapies in Breast Cancer. 2016 Apr 12 1
25 27379200 (13)C MRS and LC-MS Flux Analysis of Tumor Intermediary Metabolism. 2016 2
26 27995420 Lactic acid in tumor microenvironments causes dysfunction of NKT cells by interfering with mTOR signaling. 2016 Dec 1
27 28123869 Transcriptional and metabolic reprogramming induce an inflammatory phenotype in non-medullary thyroid carcinoma-induced macrophages. 2016 1
28 25266796 A lentiviral sponge for miRNA-21 diminishes aerobic glycolysis in bladder cancer T24 cells via the PTEN/PI3K/AKT/mTOR axis. 2015 Jan 1
29 25484022 Lactate promotes resistance to glucose starvation via upregulation of Bcl-2 mediated by mTOR activation. 2015 Feb 2
30 25807077 Tumor cells switch to mitochondrial oxidative phosphorylation under radiation via mTOR-mediated hexokinase II inhibition--a Warburg-reversing effect. 2015 1
31 26158266 Inhibition of Aerobic Glycolysis Represses Akt/mTOR/HIF-1α Axis and Restores Tamoxifen Sensitivity in Antiestrogen-Resistant Breast Cancer Cells. 2015 1
32 26251974 Cyclic mechanical stretch promotes energy metabolism in osteoblast-like cells through an mTOR signaling-associated mechanism. 2015 Oct 1
33 24496328 M(o)TOR of pseudo-hypoxic state in aging: rapamycin to the rescue. 2014 1
34 22711601 Decreased lactate concentration and glycolytic enzyme expression reflect inhibition of mTOR signal transduction pathway in B-cell lymphoma. 2013 Jan 4
35 22156546 Reduced phosphocholine and hyperpolarized lactate provide magnetic resonance biomarkers of PI3K/Akt/mTOR inhibition in glioblastoma. 2012 Mar 2
36 23181020 Computational modeling of the metabolic States regulated by the kinase akt. 2012 1
37 22156391 Yeast-like chronological senescence in mammalian cells: phenomenon, mechanism and pharmacological suppression. 2011 Nov 1