Sirolimus

mechanistic target of rapamycin kinase ; Homo sapiens







2470 Article(s)
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51 35251315 First-line everolimus and cisplatin in patients with advanced extrapulmonary neuroendocrine carcinoma: a nationwide phase 2 single-arm clinical trial. 2022 1
52 35251323 Successful treatment of sirolimus in a Chinese patient with refractory LN and APS: a case report. 2022 4
53 35253967 Sirolimus leads to rapid and sustained clinical improvement of motor deficits in a patient with inclusion body myositis. 2022 Apr 1
54 35255005 A comprehensive analysis of FOX family in HCC and experimental evidence to support the oncogenic role of FOXH1. 2022 Mar 7 2
55 35282339 Post-transplant Lymphoproliferative Disorder Following Cardiac Transplantation. 2022 2
56 35286973 The GLUT1-mTORC1 axis affects odontogenic differentiation of human dental pulp stem cells. 2022 Jun 2
57 35299066 Functional role of branched chain amino acids in poultry: a review. 2022 May 1
58 35316619 The central moTOR of metabolism. 2022 Mar 28 1
59 35330555 The Effects and Mechanisms of the Rapamycin-eluting Stent in Urethral Stricture Prevention in Rabbits. 2022 Mar 14 1
60 35337287 Anti-angiogenic properties of rapamycin on human retinal pericytes in an in vitro model of neovascular AMD via inhibition of the mTOR pathway. 2022 Mar 25 3
61 35348612 Exploring the mechanism of trehalose: dual functions of PI3K/Akt and VPS34/mTOR pathways in porcine oocytes and cumulus cells†. 2022 Mar 25 2
62 35358003 Cell senescence, rapamycin and hyperfunction theory of aging. 2022 Mar 31 1
63 35359607 Isolated Components From Spider Venom Targeting Human Glioblastoma Cells and Its Potential Combined Therapy With Rapamycin. 2022 1
64 35363301 Phase Ib/II Study of Enzalutamide with Samotolisib (LY3023414) or Placebo in Patients with Metastatic Castration-Resistant Prostate Cancer. 2022 Jun 1 1
65 35372343 Rapamycin Promotes the Expansion of Myeloid Cells by Increasing G-CSF Expression in Mesenchymal Stem Cells. 2022 4
66 35380294 Diaph3 underlines tumor cell heterogeneity in glioblastoma with implications for treatment modalities resistance. 2022 May 1
67 35391614 NRASQ61R mutation in human endothelial cells causes vascular malformations. 2022 Apr 7 1
68 35402590 Successful combinatorial therapy of sirolimus and neuraminidase inhibitors in a patient with highly pathogenic avian influenza A (H5N6) virus: a case report. 2022 Mar 2
69 35405122 Hydrophobic Derivatives of Sulfated Hyaluronic Acid as Drug Delivery Systems for Multi-Target Intra-Articular Treatment of Post-Traumatic Osteoarthritis. 2022 Apr 9 1
70 35406578 Role of mTOR through Autophagy in Esophageal Cancer Stemness. 2022 Apr 1 1
71 35428493 Rapamycin induces autophagy and apoptosis in Kaposiform hemangioendothelioma primary cells in vitro. 2022 Jul 2
72 35433677 Systematic Analysis of Stress Granule Regulators-Associated Molecular Subtypes Predicts Drug Response, Immune Response, and Prognosis in Non-Small Cell Lung Cancer. 2022 1
73 35436937 Rapamycin improves the quality and developmental competence of mice oocytes by promoting DNA damage repair during in vitro maturation. 2022 Apr 18 2
74 35444442 Enhanced Activation of mTOR Signaling Pathway Was Found in the Hypertrophic and Nodular Lesions of Port Wine Stains. 2022 2
75 35444553 Evidence for Bell-Shaped Dose-Response Emetic Effects of Temsirolimus and Analogs: The Broad-Spectrum Antiemetic Efficacy of a Large Dose of Temsirolimus Against Diverse Emetogens in the Least Shrew (Cryptotis parva). 2022 2
76 35456509 Characterization of Altered Molecular Pathways in the Entorhinal Cortex of Alzheimer's Disease Patients and In Silico Prediction of Potential Repurposable Drugs. 2022 Apr 15 1
77 35472723 β-Cell Succinate Dehydrogenase Deficiency Triggers Metabolic Dysfunction and Insulinopenic Diabetes. 2022 Apr 26 1
78 35487271 Rab22a promotes the proliferation, migration, and invasion of lung adenocarcinoma via up-regulating PI3K/Akt/mTOR signaling pathway. 2022 Jul 15 1
79 35488725 Increased mTORC2 pathway activation in lymph nodes of iMCD-TAFRO. 2022 Jun 1
80 35489420 Endothelial miR-199a-3p regulating cell adhesion molecules by targeting mTOR signaling during inflammation. 2022 Jun 15 2
81 35499412 Cutaneous perivascular epithelioid cell tumor (PEComa): case report and world literature review of clinical and molecular characteristics. 2022 Jan 15 1
82 35506423 Everolimus ameliorates Helicobacter pylori infection-induced inflammation in gastric epithelial cells. 2022 May 1
83 35521831 Challenges of rapamycin repurposing as a potential therapeutic candidate for COVID-19: implications for skeletal muscle metabolic health in older persons. 2022 Jun 1 3
84 35526176 Efficacy of sirolimus in children with lymphatic malformations of the head and neck. 2022 May 8 1
85 35571122 Effect of Combined Mycophenolate and Rapamycin Treatment on Kidney Fibrosis in Murine Lupus Nephritis. 2022 1
86 35573101 Sirolimus as a promising drug therapy for blue rubber bleb nevus syndrome: Two-case report. 2022 1
87 35585420 Retinoic acid increases the cellular cholesterol predominantly in a mTOR-independent manner. 2022 May 18 1
88 35587661 [Mechanism of microRNA-100-5p on mammalian target of rapamycin in temporomandibular arthritis]. 2022 Feb 1
89 35588700 Novel "T-Dimension" Therapies for Pediatric Optic Pathway Glioma: A Timely, Targeted, and Tailored Treatment Trend. 2022 1
90 35605444 Safety of inactivated COVID-19 vaccine in tuberous sclerosis complex patients with epilepsy treated with rapamycin. 2022 Jul 1
91 31736460 An assessment of rapamycin for weakening binge-eating memories via reconsolidation: a pre-registered, double-blind randomised placebo-controlled experimental study. 2021 Jan 1
92 32037974 Pharmacophore-guided fragment-based design of novel mammalian target of rapamycin inhibitors: extra precision docking, fingerprint-based 2D and atom-based 3D-QSAR modelling. 2021 Mar 1
93 32394479 Role of the Mammalian Target of Rapamycin Pathway in Liver Cancer: From Molecular Genetics to Targeted Therapies. 2021 Jan 2
94 32457486 Interplay between MTOR and GPX4 signaling modulates autophagy-dependent ferroptotic cancer cell death. 2021 Feb 1
95 32482020 Sirolimus Therapy and Follow-up in a Patient with Severe Congenital Hyperinsulinism Following Subtotal Pancreatectomy 2021 Feb 26 2
96 32507936 Chemoprevention in familial adenomatous polyposis: past, present and future. 2021 Jan 1
97 32803763 Long noncoding RNA NEAT1 promotes progression of glioma as a ceRNA by sponging miR-185-5p to stimulate DNMT1/mTOR signaling. 2021 Jan 2
98 32835451 Vascular endothelial growth factor receptor-3 regulates astroglial glutamate transporter-1 expression via mTOR activation in reactive astrocytes following pilocarpine-induced status epilepticus. 2021 Feb 1
99 32900356 Quercetin Inhibits AQP1 Translocation in High-Glucose-Cultured SRA01/04 Cells Through PI3K/Akt/mTOR Pathway. 2021 Oct 25 1
100 33034924 Decorin inhibits nucleus pulposus apoptosis by matrix-induced autophagy via the mTOR pathway. 2021 Aug 1