Valproic Acid

mechanistic target of rapamycin kinase ; Homo sapiens







21 Article(s)
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1 34889524 Functional characterization and potential therapeutic avenues for variants in the NTRK2 gene causing developmental and epileptic encephalopathies. 2022 Jan 1
2 35222122 Influence of Prenatal Drug Exposure, Maternal Inflammation, and Parental Aging on the Development of Autism Spectrum Disorder. 2022 1
3 32725456 Valproic Acid: A Potential Therapeutic for Spinal Cord Injury. 2021 Oct 2
4 34685502 Acute Valproate Exposure Induces Mitochondrial Biogenesis and Autophagy with FOXO3a Modulation in SH-SY5Y Cells. 2021 Sep 23 1
5 31911180 Enhanced signaling via ERBB3/PI3K plays a compensatory survival role in pancreatic tumor cells exposed to [neratinib + valproate]. 2020 Apr 1
6 33356493 Valproic Acid Enhanced Apoptosis by Promoting Autophagy Via Akt/mTOR Signaling in Glioma. 2020 Jan-Dec 4
7 31010254 Influence of the HDAC Inhibitor Valproic Acid on the Growth and Proliferation of Temsirolimus-Resistant Prostate Cancer Cells In Vitro. 2019 Apr 19 2
8 31551670 Valproic Acid Enhances Reprogramming Efficiency and Neuronal Differentiation on Small Molecules Staged-Induction Neural Stem Cells: Suggested Role of mTOR Signaling. 2019 2
9 28153093 Human Amniocytes Are Receptive to Chemically Induced Reprogramming to Pluripotency. 2017 Feb 1 2
10 28494938 PI3K/AKT/mTOR Signaling Mediates Valproic Acid-Induced Neuronal Differentiation of Neural Stem Cells through Epigenetic Modifications. 2017 May 9 1
11 29299126 HDAC inhibition as a treatment concept to combat temsirolimus-resistant bladder cancer cells. 2017 Dec 15 1
12 27588130 Valproic acid induces autophagy by suppressing the Akt/mTOR pathway in human prostate cancer cells. 2016 Sep 1
13 25627160 Decreased mTOR signaling pathway in human idiopathic autism and in rats exposed to valproic acid. 2015 Jan 20 1
14 26735433 Induction of autophagy by valproic acid enhanced lymphoma cell chemosensitivity through HDAC-independent and IP3-mediated PRKAA activation. 2015 2
15 24361750 Valproic acid enhances Oct4 promoter activity through PI3K/Akt/mTOR pathway activated nuclear receptors. 2014 Mar 5 1
16 24779401 Cross-communication between histone H3 and H4 acetylation and Akt-mTOR signalling in prostate cancer cells. 2014 Jul 1
17 23292124 Synergistic effects of histone deacetylase inhibitor in combination with mTOR inhibitor in the treatment of prostate carcinoma. 2013 Feb 1
18 23866964 Histone deacetylase inhibitor potentiated the ability of MTOR inhibitor to induce autophagic cell death in Burkitt leukemia/lymphoma. 2013 Jul 18 1
19 21192952 Inhibitory effects of the HDAC inhibitor valproic acid on prostate cancer growth are enhanced by simultaneous application of the mTOR inhibitor RAD001. 2011 Feb 28 1
20 21360059 Valproic acid modulates superoxide dismutase, uric acid-independent FRAP and zinc in blood of adult epileptic patients. 2011 Dec 1
21 16304046 FLT3-ITD-, but not BCR/ABL-transformed cells require concurrent Akt/mTor blockage to undergo apoptosis after histone deacetylase inhibitor treatment. 2006 Mar 1 1