2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one

mitogen-activated protein kinase 8 ; Homo sapiens







28 Article(s)
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1 31884678 Evidence for the critical role of the PI3K signaling pathway in particulate matter-induced dysregulation of the inflammatory mediators COX-2/PGE2 and the associated epithelial barrier protein Filaggrin in the bronchial epithelium. 2020 Aug 1
2 32174780 Suppressive effects of S100A8 and S100A9 on neutrophil apoptosis by cytokine release of human bronchial epithelial cells in asthma. 2020 1
3 30675253 Tanshinone IIA induces apoptosis of ovarian cancer cells in vitro and in vivo through attenuation of PI3K/AKT/JNK signaling pathways. 2019 Feb 1
4 26234766 PDGF-D promotes dermal fibroblast invasion in 3-dimensional extracellular matrix via Snail-mediated MT1-MMP upregulation. 2016 Jan 1
5 27895401 HER2-induced metastasis is mediated by AKT/JNK/EMT signaling pathway in gastric cancer. 2016 Nov 7 1
6 26032505 Sub-chronic administration of LY294002 sensitizes cervical cancer cells to chemotherapy by enhancing mitochondrial JNK signaling. 2015 Aug 7 1
7 26422672 Mitogen-activated protein kinases regulate expression of neuronal nitric oxide synthase and neurite outgrowth via non-classical retinoic acid receptor signaling in human neuroblastoma SH-SY5Y cells. 2015 Oct 1
8 22172327 Active lipids of Ganoderma lucidum spores-induced apoptosis in human leukemia THP-1 cells via MAPK and PI3K pathways. 2012 Jan 31 1
9 22938480 Mda-9/syntenin promotes human brain glioma migration through focal adhesion kinase (FAK)-JNK and FAK-AKT signaling. 2012 1
10 21040406 Sulfatase 2 protects hepatocellular carcinoma cells against apoptosis induced by the PI3K inhibitor LY294002 and ERK and JNK kinase inhibitors. 2010 Nov 1
11 19223550 LY303511 enhances TRAIL sensitivity of SHEP-1 neuroblastoma cells via hydrogen peroxide-mediated mitogen-activated protein kinase activation and up-regulation of death receptors. 2009 Mar 1 1
12 19428548 NF-kappaB inhibition leads to increased synthesis and secretion of MIF in human CD4+ T cells. 2009 Mar 24 1
13 19723872 Oncogenic Ras signals through activation of both phosphoinositide 3-kinase and Rac1 to induce c-Jun NH2-terminal kinase-mediated, caspase-independent cell death. 2009 Sep 1
14 17067555 Tangeretin suppresses IL-1beta-induced cyclooxygenase (COX)-2 expression through inhibition of p38 MAPK, JNK, and AKT activation in human lung carcinoma cells. 2007 Jan 15 1
15 16525641 The effects of ZD1839 (Iressa), a highly selective EGFR tyrosine kinase inhibitor, as a radiosensitiser in bile duct carcinoma cell lines. 2006 Apr 1
16 15850772 Inhibition of the PI3K pathway sensitizes fludarabine-induced apoptosis in human leukemic cells through an inactivation of MAPK-dependent pathway. 2005 Jun 3 1
17 14500571 Estrogen inhibits paclitaxel-induced apoptosis via the phosphorylation of apoptosis signal-regulating kinase 1 in human ovarian cancer cell lines. 2004 Jan 1
18 15161854 Differential involvement of phosphoinositide 3-kinase/Akt in human RPE MCP-1 and IL-8 expression. 2004 Jun 2
19 15252145 Activation of protein kinase C betaII/epsilon-c-Jun NH2-terminal kinase pathway and inhibition of mitogen-activated protein/extracellular signal-regulated kinase 1/2 phosphorylation in antitumor invasive activity induced by the polymethoxy flavonoid, nobiletin. 2004 Jul 1
20 12555073 An inhibitory function for JNK in the regulation of IGF-I signaling in breast cancer. 2003 Jan 30 2
21 11707464 Akt (protein kinase B) negatively regulates SEK1 by means of protein phosphorylation. 2002 Jan 25 1
22 12470598 Identification of DC21 as a novel target gene counter-regulated by IL-12 and IL-4. 2002 Nov 30 1
23 11158266 Insulin-like growth factor-I and Bcl-X(L) inhibit c-jun N-terminal kinase activation and rescue Schwann cells from apoptosis. 2001 Feb 1
24 11306679 Zn(2+) induces stimulation of the c-Jun N-terminal kinase signaling pathway through phosphoinositide 3-Kinase. 2001 May 1
25 11532856 Hepatocyte growth factor signalling stimulates hypoxia inducible factor-1 (HIF-1) activity in HepG2 hepatoma cells. 2001 Sep 1
26 9878764 Inhibition of phosphatidylinositol 3-kinase activity elevates c-Jun N-terminal kinase activity in apoptosis of cultured cerebellar granule neurons. 1999 Feb 5 2
27 10066822 Arachidonic acid in platelet microparticles up-regulates cyclooxygenase-2-dependent prostaglandin formation via a protein kinase C/mitogen-activated protein kinase-dependent pathway. 1999 Mar 12 1
28 10206340 Insulin activates caspase-3 by a phosphatidylinositol 3'-kinase-dependent pathway. 1999 Jan 1