Paclitaxel

mitogen-activated protein kinase 8 ; Homo sapiens







72 Article(s)
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51 14514687 The c-Jun N-terminal kinase 1 activity is differentially regulated by specific mechanisms during apoptosis. 2003 Dec 12 1
52 14529677 Mitogen-activated protein kinases (MAPK) as predictors of clinical outcome in serous ovarian carcinoma in effusions. 2003 Oct 1
53 12121974 Gamma-synuclein promotes cancer cell survival and inhibits stress- and chemotherapy drug-induced apoptosis by modulating MAPK pathways. 2002 Sep 20 2
54 11160861 Involvement of Asp-Glu-Val-Asp-directed, caspase-mediated mitogen-activated protein kinase kinase 1 Cleavage, c-Jun N-terminal kinase activation, and subsequent Bcl-2 phosphorylation for paclitaxel-induced apoptosis in HL-60 cells. 2001 Feb 5
55 11245462 Inhibition of extracellular signal-regulated kinase (ERK) mediates cell cycle phase independent apoptosis in vinblastine-treated ML-1 cells. 2001 Feb 15 1
56 11278851 Paclitaxel induces prolonged activation of the Ras/MEK/ERK pathway independently of activating the programmed cell death machinery. 2001 Jun 1 2
57 11425893 Taxol induces apoptosis in cortical neurons by a mechanism independent of Bcl-2 phosphorylation. 2001 Jul 1 7
58 11461094 Involvement of JNK-mediated pathway in EGF-mediated protection against paclitaxel-induced apoptosis in SiHa human cervical cancer cells. 2001 Jul 20 3
59 11598801 ASK1 resistant neuroblastoma is deficient in activation of p38 kinase. 2001 Oct 1
60 10623471 Microtubule inhibitors elicit differential effects on MAP kinase (JNK, ERK, and p38) signaling pathways in human KB-3 carcinoma cells. 2000 Jan 10 1
61 10823417 Paclitaxel up-regulates interleukin-8 synthesis in human lung carcinoma through an NF-kappaB- and AP-1-dependent mechanism. 2000 May 1
62 10861441 Paclitaxel-induced cell death: where the cell cycle and apoptosis come together. 2000 Jun 1 1
63 10976921 Plasma membrane estrogen receptors signal to antiapoptosis in breast cancer. 2000 Sep 5
64 11038347 MEK inhibition enhances paclitaxel-induced tumor apoptosis. 2000 Dec 15 1
65 9927194 Differential regulation of mitogen-activated protein kinases by microtubule-binding agents in human breast cancer cells. 1999 Jan 14 3
66 10075725 Microtubule dysfunction induced by paclitaxel initiates apoptosis through both c-Jun N-terminal kinase (JNK)-dependent and -independent pathways in ovarian cancer cells. 1999 Mar 19 11
67 10097113 Deletion of the loop region of Bcl-2 completely blocks paclitaxel-induced apoptosis. 1999 Mar 30 3
68 10196170 Differential involvement of MEK kinase 1 (MEKK1) in the induction of apoptosis in response to microtubule-targeted drugs versus DNA damaging agents. 1999 Apr 16 1
69 10212239 MEK kinase 1 (MEKK1) transduces c-Jun NH2-terminal kinase activation in response to changes in the microtubule cytoskeleton. 1999 Apr 30 2
70 9443400 Transient stimulation of the c-Jun-NH2-terminal kinase/activator protein 1 pathway and inhibition of extracellular signal-regulated kinase are early effects in paclitaxel-mediated apoptosis in human B lymphoblasts. 1998 Jan 15 2
71 9478937 Microtubule-interfering agents activate c-Jun N-terminal kinase/stress-activated protein kinase through both Ras and apoptosis signal-regulating kinase pathways. 1998 Feb 27 2
72 9774447 Paclitaxel (Taxol)-induced gene expression and cell death are both mediated by the activation of c-Jun NH2-terminal kinase (JNK/SAPK). 1998 Oct 23 8