Cisplatin

mitogen-activated protein kinase 8 ; Homo sapiens







140 Article(s)
Download
PMID
Title
Pub. Year
#Total Relationships
101 16518417 Dicoumarol potentiates cisplatin-induced apoptosis mediated by c-Jun N-terminal kinase in p53 wild-type urogenital cancer cell lines. 2006 Apr 20 3
102 16529740 Two distinct steps of Bak regulation during apoptotic stress signaling: different roles of MEKK1 and JNK1. 2006 May 15 1
103 16596182 Cellular components involved in the cell death induced by cisplatin in the absence of p53 activation. 2006 May 2
104 16619517 C-jun N-terminal kinase activation is required for apoptotic cell death induced by TNF-related apoptosis-inducing ligand plus DNA-damaging agents in sarcoma cell lines. 2006 Mar-Apr 5
105 16951204 Mitogen-activated protein kinase phosphatase-1 is required for cisplatin resistance. 2006 Sep 1 2
106 16984892 c-Jun NH2-terminal kinase promotes apoptosis by down-regulating the transcriptional co-repressor CtBP. 2006 Nov 17 1
107 15841377 Human cells deficient in transcription-coupled repair show prolonged activation of the Jun N-terminal kinase and increased sensitivity following cisplatin treatment. 2005 Aug 4
108 16038800 Conditional expression of MAP kinase phosphatase-2 protects against genotoxic stress-induced apoptosis by binding and selective dephosphorylation of nuclear activated c-jun N-terminal kinase. 2005 Oct 2
109 16082193 Molecular pathways in the chemosensitization of cisplatin by quercetin in human head and neck cancer. 2005 Sep 1
110 16105650 Reversing chemoresistance in cisplatin-resistant human ovarian cancer cells: a role of c-Jun NH2-terminal kinase 1. 2005 Oct 7 13
111 16238095 Role of the phosphatase PP4 in the activation of JNK-1 in prostate carcinoma cell lines PC-3 and LNCaP resulting in increased AP-1 and EGR-1 activity. 2005 1
112 16357177 Bortezomib sensitizes pancreatic cancer cells to endoplasmic reticulum stress-mediated apoptosis. 2005 Dec 15 1
113 14722256 Quantitative effects on c-Jun N-terminal protein kinase signaling determine synergistic interaction of cisplatin and 17-allylamino-17-demethoxygeldanamycin in colon cancer cell lines. 2004 Jan 4
114 15001534 Phosphorylation of FADD is critical for sensitivity to anticancer drug-induced apoptosis. 2004 Jul 1
115 15254743 Mechanisms underlying the synergistic effect of SU5416 and cisplatin on cytotoxicity in human ovarian tumor cells. 2004 Aug 1
116 15386344 Long-term activation of SAPK/JNK, p38 kinase and fas-L expression by cisplatin is attenuated in human carcinoma cells that acquired drug resistance. 2004 Dec 20 9
117 15604295 Caspase inhibitors, but not c-Jun NH2-terminal kinase inhibitor treatment, prevent cisplatin-induced hearing loss. 2004 Dec 15 1
118 12637505 Sustained activation of JNK/p38 MAPK pathways in response to cisplatin leads to Fas ligand induction and cell death in ovarian carcinoma cells. 2003 May 23 12
119 12663670 The activation of c-Jun NH2-terminal kinase (JNK) by DNA-damaging agents serves to promote drug resistance via activating transcription factor 2 (ATF2)-dependent enhanced DNA repair. 2003 Jun 6 1
120 12697749 AKT2 inhibition of cisplatin-induced JNK/p38 and Bax activation by phosphorylation of ASK1: implication of AKT2 in chemoresistance. 2003 Jun 27 4
121 14520687 Inhibition of JNK signaling diminishes early but not late cellular stress-induced apoptosis. 2003 Nov 20 1
122 12018840 Signaling and function of caspase and c-jun N-terminal kinase in cisplatin-induced apoptosis. 2002 Apr 30 5
123 12149148 An anti-GD2 monoclonal antibody enhances apoptotic effects of anti-cancer drugs against small cell lung cancer cells via JNK (c-Jun terminal kinase) activation. 2002 Jul 3
124 12181446 Regulation of platinum-compound cytotoxicity by the c-Jun N-terminal kinase and c-Jun signaling pathway in small-cell lung cancer cells. 2002 Sep 5
125 11340162 Cisplatin induces the proapoptotic conformation of Bak in a deltaMEKK1-dependent manner. 2001 Jun 1
126 11396136 Analysis of cellular sensitization with cisplatin-induced apoptosis by glucose-starved stress in cisplatin-sensitive and -resistant A431 cell line. 2001 Mar-Apr 1
127 11592233 Nicotine affects the signaling of the death pathway, reducing the response of head and neck cancer cell lines to DNA damaging agents. 2001 Oct 1
128 30147474 Activation of the JNK/SAPK and P38 Mitogen-Activated Protein Kinase Signaling Pathways Sensitize Tumor Cells to Cisplatin-Induced Apoptosis. 2001 1
129 10639576 Cisplatin-resistance involves the defective processing of MEKK1 in human ovarian adenocarcinoma 2008/C13 cells. 2000 Feb 1
130 11064451 CL100/MKP-1 modulates JNK activation and apoptosis in response to cisplatin. 2000 Oct 26 4
131 11170260 Cisplatin-induced response of c-jun N-terminal kinase 1 and extracellular signal--regulated protein kinases 1 and 2 in a series of cisplatin-resistant ovarian carcinoma cell lines. 2000 Dec 17
132 9926932 ASK1 mediates apoptotic cell death induced by genotoxic stress. 1999 Jan 7 2
133 10098743 Induction of JNK and c-Abl signalling by cisplatin and oxaliplatin in mismatch repair-proficient and -deficient cells. 1999 Mar 6
134 10353733 Cisplatin-induced activation of mitogen-activated protein kinases in ovarian carcinoma cells: inhibition of extracellular signal-regulated kinase activity increases sensitivity to cisplatin. 1999 May 4
135 10531373 Inhibition of extracellular signal-regulated protein kinase or c-Jun N-terminal protein kinase cascade, differentially activated by cisplatin, sensitizes human ovarian cancer cell line. 1999 Oct 29 6
136 9484843 Cisplatin induces a persistent activation of JNK that is related to cell death. 1998 Jan 29 3
137 10081494 EAT/mcl-1, a member of the bcl-2 related genes, confers resistance to apoptosis induced by cis-diammine dichloroplatinum (II) via a p53-independent pathway. 1998 Dec 2
138 9162025 The Jun kinase/stress-activated protein kinase pathway functions to regulate DNA repair and inhibition of the pathway sensitizes tumor cells to cisplatin. 1997 May 30 4
139 9242457 Differential induction of c-Jun NH2-terminal kinase and c-Abl kinase in DNA mismatch repair-proficient and -deficient cells exposed to cisplatin. 1997 Aug 1 6
140 9252645 The Ras farnesylation inhibitor BZA-5B increases the resistance to cisplatin in a human melanoma cell line. 1997 Jul-Aug 2