Glutathione

mitogen-activated protein kinase 8 ; Homo sapiens







55 Article(s)
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1 32996404 In silico and in vitro investigations on the protein-protein interactions of glutathione S-transferases with mitogen-activated protein kinase 8 and apoptosis signal-regulating kinase 1. 2022 Feb 1
2 29207156 MAPK inhibitors, particularly the JNK inhibitor, increase cell death effects in H2O2-treated lung cancer cells via increased superoxide anion and glutathione depletion. 2018 Feb 4
3 29627323 Apoptosis signal regulating kinase-1 and NADPH oxidase mediate human amylin evoked redox stress and apoptosis in pancreatic beta-cells. 2018 Sep 1
4 28485044 A Specific and Covalent JNK-1 Ligand Selected from an Encoded Self-Assembling Chemical Library. 2017 Jun 16 1
5 28585211 Non-Alcoholic Fatty Liver Disease. 2017 2
6 26716417 Proteome profiling of cadmium-induced apoptosis by antibody array analyses in human bronchial epithelial cells. 2016 Feb 2 1
7 26878775 Directly interact with Keap1 and LPS is involved in the anti-inflammatory mechanisms of (-)-epicatechin-3-gallate in LPS-induced macrophages and endotoxemia. 2016 May 1
8 26235743 New benzimidazole acridine derivative induces human colon cancer cell apoptosis in vitro via the ROS-JNK signaling pathway. 2015 Sep 1
9 24997392 Endoplasmic reticulum stress plays a role in the advanced glycation end product-induced inflammatory response in endothelial cells. 2014 Aug 6 1
10 23660987 MAPK inhibitors augment gallic acid-induced A549 lung cancer cell death through the enhancement of glutathione depletion. 2013 Jul 1
11 24040019 Synergistic apoptosis of CML cells by buthionine sulfoximine and hydroxychavicol correlates with activation of AIF and GSH-ROS-JNK-ERK-iNOS pathway. 2013 2
12 21523454 Assessment of the involvement of oxidative stress and Mitogen-Activated Protein Kinase signaling pathways in the cytotoxic effects of arsenic trioxide and its combination with sulindac or its metabolites: sulindac sulfide and sulindac sulfone on human leukemic cell lines. 2012 Jun 2
13 21937211 Stimulation of GSH synthesis to prevent oxidative stress-induced apoptosis by hydroxytyrosol in human retinal pigment epithelial cells: activation of Nrf2 and JNK-p62/SQSTM1 pathways. 2012 Aug 1
14 22246135 Flavonoid baicalein modulates H2O2-induced mitogen-activated protein kinases activation and cell death in SK-N-MC cells. 2012 May 2
15 22293863 MAPK inhibitors and siRNAs differentially affect cell death and ROS levels in arsenic trioxide-treated human pulmonary fibroblast cells. 2012 May 2
16 22894569 Carnosic acid prevents 6-hydroxydopamine-induced cell death in SH-SY5Y cells via mediation of glutathione synthesis. 2012 Sep 17 1
17 22906494 The effect of menadione on glutathione S-transferase A1 (GSTA1): c-Jun N-terminal kinase (JNK) complex dissociation in human colonic adenocarcinoma Caco-2 cells. 2012 Oct 2 3
18 21166414 The effects of mitogen-activated protein kinase inhibitors or small interfering RNAs on gallic acid-induced HeLa cell death in relation to reactive oxygen species and glutathione. 2011 Jan 26 3
19 21283807 Transient alteration of cellular redox buffering before irradiation triggers apoptosis in head and neck carcinoma stem and non-stem cells. 2011 Jan 19 1
20 21319226 Critical roles of cellular glutathione homeostasis and jnk activation in andrographolide-mediated apoptotic cell death in human hepatoma cells. 2011 Aug 2
21 20060865 Glutathione depletion causes a JNK and p38MAPK-mediated increase in expression of cystathionine-gamma-lyase and upregulation of the transsulfuration pathway in C6 glioma cells. 2010 Mar 3
22 21472273 The MEK inhibitor PD98059 attenuates growth inhibition and death in gallic acid-treated Calu-6 lung cancer cells by preventing glutathione depletion. 2010 May-Jun 1
23 19428345 Enhancement of esculetin on arsenic trioxide-provoked apoptosis in human leukemia U937 cells. 2009 Jun 15 1
24 19846917 The effect of MAPK inhibitors on arsenic trioxide-treated Calu-6 lung cells in relation to cell death, ROS and GSH levels. 2009 Oct 2
25 19956548 Modulation of cell surface protein free thiols: a potential novel mechanism of action of the sesquiterpene lactone parthenolide. 2009 Dec 2 1
26 20501438 Chronic oxidative stress sensitizes hepatocytes to death from 4-hydroxynonenal by JNK/c-Jun overactivation. 2009 Nov 1
27 17989939 Decreased glutathione levels potentiate the apoptotic efficacy of selenium: possible involvement of p38 and JNK MAPKs--in vitro studies. 2008 Feb 1
28 18636161 The association of deamidation of Bcl-xL and translocation of Bax to the mitochondria through activation of JNK in the induction of apoptosis by treatment with GSH-conjugated DXR. 2008 Aug 2
29 17431793 Conformational change in the active center region of GST P1-1, due to binding of a synthetic conjugate of DXR with GSH, enhanced JNK-mediated apoptosis. 2007 Jul 4
30 17481858 Glutathione prevented dopamine-induced apoptosis of melanocytes and its signaling. 2007 Aug 1
31 17920036 Regulation of p21Waf1 expression and TNFalpha biosynthesis by glutathione modulators in PMA induced-THP1 differentiation: involvement of JNK and ERK pathways. 2007 Nov 30 2
32 16337611 Peptide-bond modified glutathione conjugate analogs modulate GSTpi function in GSH-conjugation, drug sensitivity and JNK signaling. 2006 Jan 12 1
33 16543941 Aplidin induces JNK-dependent apoptosis in human breast cancer cells via alteration of glutathione homeostasis, Rac1 GTPase activation, and MKP-1 phosphatase downregulation. 2006 Nov 2
34 16582599 Depletion of intracellular glutathione contributes to JNK-mediated death receptor 5 upregulation and apoptosis induction by the novel synthetic triterpenoid methyl-2-cyano-3, 12-dioxooleana-1, 9-dien-28-oate (CDDO-Me). 2006 May 3
35 16972261 Pharmacologic inhibitors of extracellular signal-regulated kinase (ERKs) and c-Jun NH(2)-terminal kinase (JNK) decrease glutathione content and sensitize human promonocytic leukemia cells to arsenic trioxide-induced apoptosis. 2006 Dec 3
36 17065531 Protection of RPE cells from oxidative injury by 15-deoxy-delta12,14-prostaglandin J2 by augmenting GSH and activating MAPK. 2006 Nov 1
37 14701702 JNK activation is a mediator of arsenic trioxide-induced apoptosis in acute promyelocytic leukemia cells. 2004 May 1 1
38 15212948 K(+) channel activity and redox status are differentially required for JNK activation by UV and reactive oxygen species. 2004 Jul 15 1
39 18432922 Analyzing mitogen-activated protein kinase (MAPK) activities in T cells. 2004 Feb 1
40 12414812 Aplidin induces apoptosis in human cancer cells via glutathione depletion and sustained activation of the epidermal growth factor receptor, Src, JNK, and p38 MAPK. 2003 Jan 3 3
41 12819184 Epigallocatechin-3-gallate-induced stress signals in HT-29 human colon adenocarcinoma cells. 2003 Aug 1
42 12847227 c-Jun N-terminal kinase negatively regulates lipopolysaccharide-induced IL-12 production in human macrophages: role of mitogen-activated protein kinase in glutathione redox regulation of IL-12 production. 2003 Jul 15 6
43 14612554 Effects of glutathione on antioxidant response element-mediated gene expression and apoptosis elicited by sulforaphane. 2003 Nov 1 1
44 12361807 4-hydroxynonenal induces glutamate cysteine ligase through JNK in HBE1 cells. 2002 Oct 1 1
45 11279018 Down-regulation of intrinsic P-glycoprotein expression in multicellular prostate tumor spheroids by reactive oxygen species. 2001 May 18 1
46 11522656 Activation of extracellular signal-regulated kinase and c-Jun-NH(2)-terminal kinase but not p38 mitogen-activated protein kinases is required for RRR-alpha-tocopheryl succinate-induced apoptosis of human breast cancer cells. 2001 Sep 1 1
47 11768769 Induction of xenobiotic enzymes by the MAP kinase pathway and the antioxidant or electrophile response element (ARE/EpRE). 2001 Aug-Nov 1
48 10719239 Dominant-negative Jun N-terminal protein kinase (JNK-1) inhibits metabolic oxidative stress during glucose deprivation in a human breast carcinoma cell line. 2000 Feb 15 3
49 10734112 Activation of p38 and c-Jun N-terminal kinase pathways and induction of apoptosis by chelerythrine do not require inhibition of protein kinase C. 2000 Mar 31 1
50 10873716 Cellular glutathione status modulates polychlorinated biphenyl-induced stress response and apoptosis in vascular endothelial cells. 2000 Jul 1 2