protoporphyrin IX

ferrochelatase ; Mus musculus







38 Article(s)
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1 33620374 Retinal Phenotyping of Ferrochelatase Mutant Mice Reveals Protoporphyrin Accumulation and Reduced Neovascular Response. 2021 Feb 1 1
2 31990410 Mild iron deficiency does not ameliorate the phenotype of a murine erythropoietic protoporphyria model. 2020 May 2
3 33335181 MEK reduces cancer-specific PpIX accumulation through the RSK-ABCB1 and HIF-1α-FECH axes. 2020 Dec 17 9
4 31748741 PGRMC2 is an intracellular haem chaperone critical for adipocyte function. 2019 Dec 1
5 29906468 Liver metabolomics in a mouse model of erythropoietic protoporphyria. 2018 Aug 6
6 28093505 Modeling the ferrochelatase c.315-48C modifier mutation for erythropoietic protoporphyria (EPP) in mice. 2017 Mar 1 3
7 27438535 Chronic Treatment with Isoniazid Causes Protoporphyrin IX Accumulation in Mouse Liver. 2016 Aug 15 2
8 25659899 Heme biosynthesis modulation via δ-aminolevulinic acid administration attenuates chronic hypoxia-induced pulmonary hypertension. 2015 Apr 1 1
9 26343413 A metabolomic perspective of griseofulvin-induced liver injury in mice. 2015 Dec 1 2
10 24284092 The inhibition of ferrochelatase enhances 5-aminolevulinic acid-based photodynamic action for prostate cancer. 2013 Dec 3
11 22349098 In vivo tumor imaging using a novel RNAi-based detection mechanism. 2012 May 5
12 21222436 Nickel(II) chelatase variants directly evolved from murine ferrochelatase: porphyrin distortion and kinetic mechanism. 2011 Mar 8 2
13 20966079 Identification and characterization of an inhibitory metal ion-binding site in ferrochelatase. 2010 Dec 31 1
14 19251765 Post-transcriptional regulation of the expression of ferrochelatase by its variant mRNA. 2009 Jun 2
15 19543923 Molecular dynamics simulations of mouse ferrochelatase variants: what distorts and orientates the porphyrin? 2009 Sep 1
16 18593702 Metal ion substrate inhibition of ferrochelatase. 2008 Aug 29 2
17 19787086 Level of expression of the nonmutant Ferrochelatase allele is a determinant of biochemical phenotype in a mouse model of erythropoietic protoporphyria. 2008 May 29 2
18 17314268 Breast cancer resistance protein (Bcrp1/Abcg2) is expressed in the harderian gland and mediates transport of conjugated protoporphyrin IX. 2007 Jun 1
19 16792525 Modulation of inhibition of ferrochelatase by N-methylprotoporphyrin. 2006 Oct 1 1
20 15496139 Porphyrin-substrate binding to murine ferrochelatase: effect on the thermal stability of the enzyme. 2005 Mar 15 2
21 15654982 Prevention of murine erythropoietic protoporphyria-associated skin photosensitivity and liver disease by dermal and hepatic ferrochelatase. 2005 Jan 2
22 16288996 Mechanisms involved in delta-aminolevulinic acid (ALA)-induced photosensitivity of tumor cells: relation of ferrochelatase and uptake of ALA to the accumulation of protoporphyrin. 2005 Dec 19 4
23 14981080 Probing the active site loop motif of murine ferrochelatase by random mutagenesis. 2004 May 7 1
24 15284838 Hematopoietic stem cell gene therapy of murine protoporphyria by methylguanine-DNA-methyltransferase-mediated in vivo drug selection. 2004 Nov 1
25 11939775 Unraveling the substrate-metal binding site of ferrochelatase: an X-ray absorption spectroscopic study. 2002 Apr 16 1
26 12081474 Binding of protoporphyrin IX and metal derivatives to the active site of wild-type mouse ferrochelatase at low porphyrin-to-protein ratios. 2002 Jul 2 2
27 12149233 An exon 10 deletion in the mouse ferrochelatase gene has a dominant-negative effect and causes mild protoporphyria. 2002 Aug 15 1
28 12359345 Protoporphyrin-IX accumulation and cutaneous tumor regression in mice using a ferrochelatase inhibitor. 2002 Dec 10 1
29 11336654 Substitution of murine ferrochelatase glutamate-287 with glutamine or alanine leads to porphyrin substrate-bound variants. 2001 May 15 1
30 10704201 Porphyrin interactions with wild-type and mutant mouse ferrochelatase. 2000 Mar 14 1
31 10869291 Reversion of hepatobiliary alterations By bone marrow transplantation in a murine model of erythropoietic protoporphyria. 2000 Jul 2
32 10089831 Protoporphyrin IX-sensitized photoinactivation of 5-aminolevulinate-treated leukemia cells: effects of exogenous iron. 1999 Mar 1
33 10464147 Biliary fibrosis associated with altered bile composition in a mouse model of erythropoietic protoporphyria. 1999 Sep 1
34 10523727 Ferrochelatase, a novel target for photodynamic therapy of cancer. 1999 Nov-Dec 1
35 8266338 Effects of 2-[1-(ethoxyimino)propyl]-3-hydroxy-5-(2,4,6-trimethylphenyl) cyclohex-2-enone on hepatic haem biosynthesis: species differences in hepatic porphyria. 1993 Nov 12 1
36 8358292 In situ conversion of coproporphyrinogen to heme by murine mitochondria: terminal steps of the heme biosynthetic pathway. 1993 Jul 1
37 1288876 [Ferrochelatase gene expression in erythroid cells]. 1992 Dec 4 2
38 1704134 Cloning of murine ferrochelatase. 1991 Feb 1 2