| 1 |
34742015 | Structural and PK-guided identification of indole-based non-acidic autotaxin (ATX) inhibitors exhibiting high in vivo anti-fibrosis efficacy in rodent model. | 2022 Jan 5 |
3 |
| 2 |
34847837 | Aberrant ENPP2 expression promotes tumor progression in multiple myeloma. | 2022 Apr |
1 |
| 3 |
35398277 | Autotaxin signaling facilitates β cell dedifferentiation and dysfunction induced by Sirtuin 3 deficiency. | 2022 Jun |
8 |
| 4 |
35456953 | The ATX-LPA Axis Regulates Vascular Permeability during Cerebral Ischemic-Reperfusion. | 2022 Apr 8 |
1 |
| 5 |
33524376 | Suppressing postcollection lysophosphatidic acid metabolism improves the precision of plasma LPA quantification. | 2021 |
7 |
| 6 |
33597645 | Inhibition of autotaxin activity ameliorates neuropathic pain derived from lumbar spinal canal stenosis. | 2021 Feb 17 |
4 |
| 7 |
33778909 | A role for bronchial epithelial autotaxin in ventilator-induced lung injury. | 2021 Mar 29 |
6 |
| 8 |
34319110 | Positron Emission Tomography Imaging of Autotaxin in Thyroid and Breast Cancer Models Using [18F]PRIMATX. | 2021 Sep 6 |
4 |
| 9 |
34445223 | Inhibition of Autotaxin and Lysophosphatidic Acid Receptor 5 Attenuates Neuroinflammation in LPS-Activated BV-2 Microglia and a Mouse Endotoxemia Model. | 2021 Aug 7 |
3 |
| 10 |
34514847 | Disrupted Blood-Brain Barrier and Mitochondrial Impairment by Autotaxin-Lysophosphatidic Acid Axis in Postischemic Stroke. | 2021 Sep 21 |
2 |
| 11 |
34788605 | Autotaxin impedes anti-tumor immunity by suppressing chemotaxis and tumor infiltration of CD8+ T cells. | 2021 Nov 16 |
6 |
| 12 |
34829956 | Enpp2 Expression by Dendritic Cells Is a Key Regulator in Migration. | 2021 Nov 19 |
2 |
| 13 |
31548293 | Inhibition of Autotaxin with GLPG1690 Increases the Efficacy of Radiotherapy and Chemotherapy in a Mouse Model of Breast Cancer. | 2020 Jan |
1 |
| 14 |
31805399 | Ectonucleotide pyrophosphatase 2 (ENPP2) plays a crucial role in myogenic differentiation through the regulation by WNT/β-Catenin signaling. | 2020 Jan |
7 |
| 15 |
32326963 | MAPK signaling determines lysophosphatidic acid (LPA)-induced inflammation in microglia. | 2020 Apr 23 |
4 |
| 16 |
32479084 | Discovery of Novel Indole-Based Allosteric Highly Potent ATX Inhibitors with Great In Vivo Efficacy in a Mouse Lung Fibrosis Model. | 2020 Jul 9 |
4 |
| 17 |
32875703 | Autotaxin loss accelerates intestinal inflammation by suppressing TLR4-mediated immune responses. | 2020 Oct 5 |
2 |
| 18 |
33017574 | Autotaxin inhibition reduces cardiac inflammation and mitigates adverse cardiac remodeling after myocardial infarction. | 2020 Dec |
4 |
| 19 |
33128578 | Autotaxin stimulates LPA2 receptor in macrophages and exacerbates dextran sulfate sodium-induced acute colitis. | 2020 Dec |
4 |
| 20 |
30395215 | Activated platelets promote an osteogenic programme and the progression of calcific aortic valve stenosis. | 2019 May 1 |
2 |
| 21 |
30450805 | Autotaxin/lysophosphatidic acid signaling mediates obesity-related cardiomyopathy in mice and human subjects. | 2019 Feb |
1 |
| 22 |
30481488 | Autotaxin determines colitis severity in mice and is secreted by B cells in the colon. | 2019 Mar |
6 |
| 23 |
30730895 | Adipose-derived autotaxin regulates inflammation and steatosis associated with diet-induced obesity. | 2019 |
4 |
| 24 |
30881959 | Autotaxin and Lipoprotein Metabolism in Calcific Aortic Valve Disease. | 2019 |
2 |
| 25 |
30999934 | Antifibrotic effects of 2-carba cyclic phosphatidic acid (2ccPA) in systemic sclerosis: contribution to the novel treatment. | 2019 Apr 18 |
4 |
| 26 |
31092842 | The involvement of autotaxin in renal interstitial fibrosis through regulation of fibroblast functions and induction of vascular leakage. | 2019 May 15 |
3 |
| 27 |
31429784 | Abrogation of lysophosphatidic acid receptor 1 ameliorates murine vasculitis. | 2019 Aug 20 |
4 |
| 28 |
31794025 | Characterization of glycerophosphodiesterase 4-interacting molecules Gαq/11 and Gβ, which mediate cellular lysophospholipase D activity. | 2019 Dec 19 |
1 |
| 29 |
29620892 | Hydroxamic Acids Constitute a Novel Class of Autotaxin Inhibitors that Exhibit in Vivo Efficacy in a Pulmonary Fibrosis Model. | 2018 Apr 26 |
4 |
| 30 |
30072447 | Autotaxin-LPA signaling contributes to obesity-induced insulin resistance in muscle and impairs mitochondrial metabolism. | 2018 Oct |
4 |
| 31 |
30118349 | Inhibition of autotaxin alleviates inflammation and increases the expression of sodium-dependent glucose cotransporter 1 and Na+/H+ exchanger 3 in SAMP1/Fc mice. | 2018 Nov 1 |
1 |
| 32 |
30237860 | Autotaxin-β interaction with the cell surface via syndecan-4 impacts on cancer cell proliferation and metastasis. | 2018 Sep 4 |
4 |
| 33 |
27754931 | Selective Inhibition of Autotaxin Is Efficacious in Mouse Models of Liver Fibrosis. | 2017 Jan |
5 |
| 34 |
27981605 | Hepatocyte autotaxin expression promotes liver fibrosis and cancer. | 2017 Apr |
1 |
| 35 |
28069607 | Lysophosphatidic acid converts monocytes into macrophages in both mice and humans. | 2017 Mar 2 |
2 |
| 36 |
28073697 | Proliferation of mouse endometrial stromal cells in culture is highly sensitive to lysophosphatidic acid signaling. | 2017 Feb 26 |
2 |
| 37 |
28111010 | Blocking lysophosphatidic acid receptor 1 signaling inhibits diabetic nephropathy in db/db mice. | 2017 Jun |
1 |
| 38 |
28240604 | Autocrine lysophosphatidic acid signaling activates β-catenin and promotes lung allograft fibrosis. | 2017 Apr 3 |
1 |
| 39 |
28324037 | Autotaxin Is Regulated by Glucose and Insulin in Adipocytes. | 2017 Apr 1 |
2 |
| 40 |
28460477 | Inhibition of lysophosphatidic acid receptor ameliorates Sjögren's syndrome in NOD mice. | 2017 Apr 18 |
1 |
| 41 |
28758906 | Activin-A enhances mTOR signaling to promote aberrant chondrogenesis in fibrodysplasia ossificans progressiva. | 2017 Sep 1 |
1 |
| 42 |
28874440 | Blocking gp130 signaling suppresses autotaxin expression in adipocytes and improves insulin sensitivity in diet-induced obesity. | 2017 Nov |
4 |
| 43 |
26714589 | Lysophosphatidic acid receptors LPA4 and LPA6 differentially promote lymphocyte transmigration across high endothelial venules in lymph nodes. | 2016 Jun |
5 |
| 44 |
26808693 | Polyunsaturated lysophosphatidic acid as a potential asthma biomarker. | 2016 |
3 |
| 45 |
27005960 | ATX-LPA1 axis contributes to proliferation of chondrocytes by regulating fibronectin assembly leading to proper cartilage formation. | 2016 Mar 23 |
2 |
| 46 |
27006447 | Autotaxin activity increases locally following lung injury, but is not required for pulmonary lysophosphatidic acid production or fibrosis. | 2016 Jun |
4 |
| 47 |
27019050 | Autotaxin, Pruritus and Primary Biliary Cholangitis (PBC). | 2016 Aug |
1 |
| 48 |
27178323 | The phospholipase A2 activity of peroxiredoxin 6 modulates NADPH oxidase 2 activation via lysophosphatidic acid receptor signaling in the pulmonary endothelium and alveolar macrophages. | 2016 Aug |
3 |
| 49 |
27283020 | Fingolimod promotes peripheral nerve regeneration via modulation of lysophospholipid signaling. | 2016 Jun 10 |
1 |
| 50 |
27390295 | An Autotaxin/Lysophosphatidic Acid/Interleukin-6 Amplification Loop Drives Scleroderma Fibrosis. | 2016 Dec |
1 |