| 1 |
34998040 | Discovery of a tricyclic farnesoid X receptor agonist HEC96719, a clinical candidate for treatment of non-alcoholic steatohepatitis. | 2022 Feb 15 |
2 |
| 2 |
34145381 | Bile acid-induced tissue factor activity in hepatocytes correlates with activation of farnesoid X receptor. | 2021 Oct |
2 |
| 3 |
34256254 | Discovery of novel ketoxime ether derivatives with potent FXR agonistic activity, oral effectiveness and high liver/blood ratio. | 2021 Aug 1 |
2 |
| 4 |
34888230 | Norcholic Acid Promotes Tumor Progression and Immune Escape by Regulating Farnesoid X Receptor in Hepatocellular Carcinoma. | 2021 |
1 |
| 5 |
31911244 | Geniposide reduces cholesterol accumulation and increases its excretion by regulating the FXR-mediated liver-gut crosstalk of bile acids. | 2020 Feb |
1 |
| 6 |
32341465 | Diabetes downregulates peptide transporter 1 in the rat jejunum: possible involvement of cholate-induced FXR activation. | 2020 Nov |
3 |
| 7 |
32565960 | Effects and mechanism of the bile acid (farnesoid X) receptor on the Wnt/β-catenin signaling pathway in colon cancer. | 2020 Jul |
2 |
| 8 |
32846898 | Farnesoid X Receptor Activation Stimulates Organic Cations Transport in Human Renal Proximal Tubular Cells. | 2020 Aug 24 |
1 |
| 9 |
30428773 | Farnesoid X Receptor Agonist GW4064 Inhibits Aromatase and ERβ Expression in Human Endometriotic Stromal Cells. | 2019 Aug |
2 |
| 10 |
30747230 | Bile acids promote gastric intestinal metaplasia by upregulating CDX2 and MUC2 expression via the FXR/NF-κB signalling pathway. | 2019 Mar |
1 |
| 11 |
30902657 | Farnesoid X receptor agonist GW4064 indirectly inhibits HCV entry into cells via down-regulating scavenger receptor class B type I. | 2019 Jun 15 |
3 |
| 12 |
31095863 | Trimethylamine N-Oxide Aggravates Liver Steatosis through Modulation of Bile Acid Metabolism and Inhibition of Farnesoid X Receptor Signaling in Nonalcoholic Fatty Liver Disease. | 2019 Sep |
1 |
| 13 |
31561852 | Farnesoid X receptor induces cell death and sensitizes to TRAIL-induced inhibition of growth in colorectal cancer cells through the up-regulation of death receptor 5. | 2019 Nov 19 |
1 |
| 14 |
31779647 | Upregulation of microRNA-23b-3p induced by farnesoid X receptor regulates the proliferation and apoptosis of osteosarcoma cells. | 2019 Nov 28 |
2 |
| 15 |
29351391 | The bile acids, deoxycholic acid and ursodeoxycholic acid, regulate colonic epithelial wound healing. | 2018 Mar 1 |
1 |
| 16 |
29849798 | Activation of FXR promotes intestinal metaplasia of gastric cells via SHP-dependent upregulation of the expression of CDX2. | 2018 May |
1 |
| 17 |
29958417 | Farnesoid X Receptor Activation Enhances Transforming Growth Factor β-Induced Epithelial-Mesenchymal Transition in Hepatocellular Carcinoma Cells. | 2018 Jun 28 |
1 |
| 18 |
30106441 | Farnesoid X receptor inhibits proliferation of human colorectal cancer cells via the miR‑135A1/CCNG2 signaling pathway. | 2018 Oct |
2 |
| 19 |
30176263 | Activation of Farnesoid X Receptor impairs the tumor-promoting function of breast cancer-associated fibroblasts. | 2018 Nov 28 |
2 |
| 20 |
26646674 | AMPK activation by liquiritigenin inhibited oxidative hepatic injury and mitochondrial dysfunction induced by nutrition deprivation as mediated with induction of farnesoid X receptor. | 2017 Mar |
4 |
| 21 |
28267333 | Transcriptional Regulation of Human UDP-Glucuronosyltransferase 2B10 by Farnesoid X Receptor in Human Hepatoma HepG2 Cells. | 2017 Sep 5 |
1 |
| 22 |
28787755 | A rapid administration of GW4064 inhibits the NLRP3 inflammasome activation independent of farnesoid X receptor agonism. | 2017 Sep |
4 |
| 23 |
29283075 | Evaluation of Farnesoid X Receptor Target Gene Induction in Human Hepatocytes: Amino Acid Conjugation. | 2017 |
1 |
| 24 |
26450152 | Activation of farnesoid X receptor downregulates visfatin and attenuates diabetic nephropathy. | 2016 Jan 5 |
1 |
| 25 |
26545738 | Activation of the Farnesoid X-receptor in breast cancer cell lines results in cytotoxicity but not increased migration potential. | 2016 Jan 28 |
1 |
| 26 |
26899873 | Activated FXR Inhibits Leptin Signaling and Counteracts Tumor-promoting Activities of Cancer-Associated Fibroblasts in Breast Malignancy. | 2016 Feb 22 |
1 |
| 27 |
27127878 | FXR agonists enhance the sensitivity of biliary tract cancer cells to cisplatin via SHP dependent inhibition of Bcl-xL expression. | 2016 Jun 7 |
1 |
| 28 |
27251172 | Reciprocal regulation of farnesoid X receptor α activity and hepatitis B virus replication in differentiated HepaRG cells and primary human hepatocytes. | 2016 Sep |
1 |
| 29 |
27471003 | Activation of farnesoid X receptor promotes triglycerides lowering by suppressing phospholipase A2 G12B expression. | 2016 Nov 15 |
1 |
| 30 |
27758768 | Farnesoid X Receptor and Its Ligands Inhibit the Function of Platelets. | 2016 Dec |
3 |
| 31 |
28066584 | Overexpression of farnesoid X receptor in small airways contributes to epithelial to mesenchymal transition and COX-2 expression in chronic obstructive pulmonary disease. | 2016 Nov |
1 |
| 32 |
25466848 | Glucocorticoids as modulators of expression and activity of Antithrombin (At): potential clinical relevance. | 2015 Jan |
1 |
| 33 |
25496033 | Farnesoid X receptor antagonizes JNK signaling pathway in liver carcinogenesis by activating SOD3. | 2015 Feb |
1 |
| 34 |
25499883 | Novel heterocyclic scaffolds of GW4064 as farnesoid X receptor agonists. | 2015 Jan 15 |
1 |
| 35 |
25934227 | Fragmentation of GW4064 led to a highly potent partial farnesoid X receptor agonist with improved drug-like properties. | 2015 Jul 1 |
3 |
| 36 |
26098428 | Chenodeoxycholic Acid Reduces Hypoxia Inducible Factor-1α Protein and Its Target Genes. | 2015 |
1 |
| 37 |
26324224 | Farnesoid X receptor signal is involved in deoxycholic acid-induced intestinal metaplasia of normal human gastric epithelial cells. | 2015 Nov |
1 |
| 38 |
26583035 | FXR expression is associated with dysregulated glucose and lipid levels in the offspring kidney induced by maternal obesity. | 2015 |
2 |
| 39 |
23916961 | Farnesoid X receptor agonists attenuate colonic epithelial secretory function and prevent experimental diarrhoea in vivo. | 2014 May |
1 |
| 40 |
24321096 | SREBP-2 negatively regulates FXR-dependent transcription of FGF19 in human intestinal cells. | 2014 Jan 10 |
1 |
| 41 |
24463129 | [Effects of farnesoid X receptor agonist on adiponectin and its receptors]. | 2014 Jan |
1 |
| 42 |
24597548 | Synthetic FXR agonist GW4064 is a modulator of multiple G protein-coupled receptors. | 2014 May |
6 |
| 43 |
25010412 | Bile acids reduce endocytosis of high-density lipoprotein (HDL) in HepG2 cells. | 2014 |
2 |
| 44 |
25388536 | Knocking on FXR's door: the "hammerhead"-structure series of FXR agonists - amphiphilic isoxazoles with potent in vitro and in vivo activities. | 2014 |
3 |
| 45 |
23313557 | FXR-dependent and -independent interaction of glucocorticoids with the regulatory pathways involved in the control of bile acid handling by the liver. | 2013 Mar 15 |
3 |
| 46 |
23541942 | Regulation of N-Myc downstream regulated gene 2 by bile acids. | 2013 Apr 26 |
1 |
| 47 |
23680185 | Activation of the nuclear receptor FXR enhances hepatocyte chemoprotection and liver tumor chemoresistance against genotoxic compounds. | 2013 Oct |
4 |
| 48 |
23688559 | Development of time resolved fluorescence resonance energy transfer-based assay for FXR antagonist discovery. | 2013 Jul 15 |
1 |
| 49 |
23767959 | Diacylglycerol kinase θ couples farnesoid X receptor-dependent bile acid signalling to Akt activation and glucose homoeostasis in hepatocytes. | 2013 Sep 1 |
2 |
| 50 |
23772048 | Regulation of human class I alcohol dehydrogenases by bile acids. | 2013 Sep |
1 |