Simvastatin

BCL2 apoptosis regulator ; Homo sapiens







24 Article(s)
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1 32633363 Simvastatin induces apoptosis of nasopharyngeal carcinoma cells through NF-κB signaling pathway. 2020 Jun 1
2 31319483 Simvastatin Induces Apoptosis in Medulloblastoma Brain Tumor Cells via Mevalonate Cascade Prenylation Substrates. 2019 Jul 17 1
3 31663349 Neural stem cells neuroprotection by simvastatin via autophagy induction and apoptosis inhibition. 2019 1
4 29532878 Simvastatin exerts anticancer effects in osteosarcoma cell lines via geranylgeranylation and c-Jun activation. 2018 Apr 1
5 29985281 Simvastatin Treatment Protects Myocardium in Noncoronary Artery Cardiac Surgery by Inhibiting Apoptosis Through miR-15a-5p Targeting. 2018 Oct 3
6 27109251 Activation of endothelial NO synthase by a xanthine derivative ameliorates hypoxia-induced apoptosis in endothelial progenitor cells. 2016 Jun 1
7 25738368 Molecular mechanism underlying the anticancer effect of simvastatin on MDA-MB-231 human breast cancer cells. 2015 Jul 3
8 24233024 Simvastatin sensitizes human gastric cancer xenograft in nude mice to capecitabine by suppressing nuclear factor-kappa B-regulated gene products. 2014 Mar 1
9 25548604 Simvastatin inhibits apoptosis of endothelial cells induced by sepsis through upregulating the expression of Bcl-2 and downregulating Bax. 2014 4
10 23559002 Deciphering the signaling networks underlying simvastatin-induced apoptosis in human cancer cells: evidence for non-canonical activation of RhoA and Rac1 GTPases. 2013 Apr 4 1
11 23769741 Simvastatin enhances human osteoblast proliferation involved in mitochondrial energy generation. 2013 Aug 15 7
12 23924855 Simvastatin inhibits proliferation and induces apoptosis in human lung cancer cells. 2013 1
13 22012179 Simvastatin protects human osteosarcoma cells from oxidative stress-induced apoptosis through mitochondrial-mediated signaling. 2012 Feb 1
14 22052376 The pleiotropic effects of statins in the prevention of atherosclerosis : Editorial to: "Simvastatin suppresses apoptosis in vulnerable atherosclerotic plaques through regulating the expression of p53, Bcl-2 en Bcl-xL" by Weiwei Qin et al. 2012 Feb 1
15 22080086 Simvastatin impairs ADP-stimulated respiration and increases mitochondrial oxidative stress in primary human skeletal myotubes. 2012 Jan 1 1
16 22134829 Simvastatin inhibits cancer cell growth by inducing apoptosis correlated to activation of Bax and down-regulation of BCL-2 gene expression. 2012 Apr 2
17 22974127 Simultaneous modulation of the intrinsic and extrinsic pathways by simvastatin in mediating prostate cancer cell apoptosis. 2012 Sep 14 1
18 21958871 Involvement of Chk1-Cdc25A-cyclin A/CDK2 pathway in simvastatin induced S-phase cell cycle arrest and apoptosis in multiple myeloma cells. 2011 Nov 30 2
19 20369390 Simvastatin stimulates production of the antiapoptotic protein Bcl-2 via endothelin-1 and NFATc3 in SH-SY5Y cells. 2010 Jun 8
20 20499237 Simvastatin and purine analogs have a synergic effect on apoptosis of chronic lymphocytic leukemia cells. 2010 Nov 1
21 17241114 Simvastatin protects neurons from cytotoxicity by up-regulating Bcl-2 mRNA and protein. 2007 Apr 9
22 17901590 Inhibition of Barret's adenocarcinoma cell growth by simvastatin: involvement of COX-2 and apoptosis-related proteins. 2007 Aug 2
23 15163549 Apoptotic injury in cultured human hepatocytes induced by HMG-CoA reductase inhibitors. 2004 Jun 15 1
24 11882313 3-Hydroxy-3-methyl-glutaryl coenzyme A reductase inhibitors, atorvastatin and simvastatin, induce apoptosis of vascular smooth muscle cells by downregulation of Bcl-2 expression and Rho A prenylation. 2002 Mar 2