pyrazolanthrone

BCL2 apoptosis regulator ; Homo sapiens







40 Article(s)
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1 31868268 DJ-1 inhibits autophagy activity of prostate cancer cells by repressing JNK-Bcl2-Beclin1 signaling. 2020 Apr 1
2 32251495 Role of the MAPK pathway in human lung epithelial-like A549 cells apoptosis induced by paraquat. 2020 1
3 30368882 MAPKs and NF-κB-mediated acrylamide-induced neuropathy in rat striatum and human neuroblastoma cells SY5Y. 2019 Mar 2
4 31357761 [Effect and mechanism of liraglutide on the apoptosis of human hepatocellular carcinoma HepG2 cells induced with palmitic acid]. 2019 Jun 20 1
5 31362241 ANXA3 Silencing Ameliorates Intracranial Aneurysm via Inhibition of the JNK Signaling Pathway. 2019 Sep 6 1
6 31906029 Activation of PERK Contributes to Apoptosis and G2/M Arrest by Microtubule Disruptors in Human Colorectal Carcinoma Cells . 2019 Dec 30 2
7 29725459 MAPK/c-Jun signaling pathway contributes to the upregulation of the anti-apoptotic proteins Bcl-2 and Bcl-xL induced by Epstein-Barr virus-encoded BARF1 in gastric carcinoma cells. 2018 May 1
8 30290166 Deoxynivalenol induces toxicity and apoptosis in piglet hippocampal nerve cells via the MAPK signaling pathway. 2018 Dec 1 1
9 28455228 Brusatol inhibits growth and induces apoptosis in pancreatic cancer cells via JNK/p38 MAPK/NF-κb/Stat3/Bcl-2 signaling pathway. 2017 Jun 10 1
10 29250183 Ampelopsin-induced reactive oxygen species enhance the apoptosis of colon cancer cells by activating endoplasmic reticulum stress-mediated AMPK/MAPK/XAF1 signaling. 2017 Dec 2
11 26849940 Dioscin suppresses human laryngeal cancer cells growth via induction of cell-cycle arrest and MAPK-mediated mitochondrial-derived apoptosis and inhibition of tumor invasion. 2016 Mar 5 1
12 27233606 SP600125 enhances the anti-apoptotic capacity and migration of bone marrow mesenchymal stem cells treated with tumor necrosis factor-α. 2016 Jul 8 2
13 27263652 Synergistic chemopreventive effects of curcumin and berberine on human breast cancer cells through induction of apoptosis and autophagic cell death. 2016 Jun 6 1
14 25178491 2-(Pro-1-ynyl)-5-(5,6-dihydroxypenta-1,3-diynyl) thiophene induces apoptosis through reactive oxygen species-mediated JNK activation in human colon cancer SW620 cells. 2015 Feb 1
15 25958204 Buforin IIb induces endoplasmic reticulum stress-mediated apoptosis in HeLa cells. 2015 Jul 1
16 24733045 JNK confers 5-fluorouracil resistance in p53-deficient and mutant p53-expressing colon cancer cells by inducing survival autophagy. 2014 Apr 15 1
17 23423712 Apoptosis induced by trimethyltin chloride in human neuroblastoma cells SY5Y is regulated by a balance and cross-talk between NF-κB and MAPKs signaling pathways. 2013 Jul 1
18 22323130 Resistance to paclitaxel in hepatoma cells is related to static JNK activation and prohibition into entry of mitosis. 2012 May 1 1
19 22870247 Increased JNK1 signaling pathway is responsible for ABCG2-mediated multidrug resistance in human colon cancer. 2012 1
20 23123629 Role of JNK and p38 MAPK in Taiwanin A-induced cell death. 2012 Dec 17 1
21 19747539 Naphtho[1,2-b]furan-4,5-dione induces apoptosis and S-phase arrest of MDA-MB-231 cells through JNK and ERK signaling activation. 2010 Feb 1
22 20144638 Involvement of p38 MAPK- and JNK-modulated expression of Bcl-2 and Bax in Naja nigricollis CMS-9-induced apoptosis of human leukemia K562 cells. 2010 Jun 15 1
23 20346929 Butyrate induces cell apoptosis through activation of JNK MAP kinase pathway in human colon cancer RKO cells. 2010 May 14 1
24 20920558 Pyrrolidine dithiocarbamate (PDTC)/Cu complex induces lung epithelial cell apoptosis through mitochondria and ER-stress pathways. 2010 Dec 15 1
25 18534198 Requirement of the JNK-associated Bcl-2 pathway for human lactoferrin-induced apoptosis in the Jurkat leukemia T cell line. 2009 Jan 1
26 19206150 JNK is constitutively active in mantle cell lymphoma: cell cycle deregulation and polyploidy by JNK inhibitor SP600125. 2009 May 1
27 19478553 JNK inhibitor SP600125 promotes the formation of polymerized tubulin, leading to G2/M phase arrest, endoreduplication, and delayed apoptosis. 2009 Sep 30 1
28 19540902 Arachidonic acid-induced apoptosis of human neuroblastoma SK-N-SH cells is mediated through mitochondrial alteration elicited by ROS and Ca(2+)-evoked activation of p38alpha MAPK and JNK1. 2009 Aug 21 1
29 19616639 Anti-apoptotic action of hydrogen sulfide is associated with early JNK inhibition. 2009 Oct 1
30 19699753 Novel indoloquinoline derivative, IQDMA, induces G(2)/M phase arrest and apoptosis in A549 cells through JNK/p38 MAPK signaling activation. 2009 Sep 23 1
31 19801848 Costunolide-induced apoptosis in human leukemia cells: involvement of c-jun N-terminal kinase activation. 2009 Oct 1
32 18343029 Bcl-2 overexpression attenuates SP600125-induced apoptosis in human leukemia U937 cells. 2008 Jun 18 5
33 18412143 The role of p38 MAPK and JNK in Arsenic trioxide-induced mitochondrial cell death in human cervical cancer cells. 2008 Oct 1
34 18600231 On the role of major vault protein in the resistance of senescent human diploid fibroblasts to apoptosis. 2008 Nov 1
35 18695917 Role of p38 MAPK and JNK in enhanced cervical cancer cell killing by the combination of arsenic trioxide and ionizing radiation. 2008 Sep 1
36 16420771 [Effects of sp600125 on proliferation and protein expression of bcl-2 and c-myc in hepatic stellate cells]. 2006 Jan 1
37 17054427 The c-Jun-N-terminal-Kinase inhibitor SP600125 enhances the butyrate derivative D1-induced apoptosis via caspase 8 activation in Kasumi 1 t(8;21) acute myeloid leukaemia cells. 2006 Dec 1
38 15703383 Cephalostatin 1 inactivates Bcl-2 by hyperphosphorylation independent of M-phase arrest and DNA damage. 2005 May 1
39 16149076 Amplification loop cascade for increasing caspase activity induced by docetaxel. 2005 Nov 1 1
40 15184882 Diallyl trisulfide-induced apoptosis in human prostate cancer cells involves c-Jun N-terminal kinase and extracellular-signal regulated kinase-mediated phosphorylation of Bcl-2. 2004 Jul 22 1