| 1 |
34376056 | Allele-Specific Knockdown of Mutant Huntingtin Protein via Editing at Coding Region Single Nucleotide Polymorphism Heterozygosities. | 2022 Jan |
1 |
| 2 |
34806402 | Efficient and Precise Processing of the Optimized Primary Artificial MicroRNA in a Huntingtin-Lowering Adeno-Associated Viral Gene Therapy In Vitro and in Mice and Nonhuman Primates. | 2022 Jan |
3 |
| 3 |
35108063 | Development of a ligand for in vivo imaging of mutant huntingtin in Huntington's disease. | 2022 Feb 2 |
1 |
| 4 |
35129568 | Spatial proteomic alterations detected via MALDI-MS imaging implicate neuronal loss in a Huntington's disease mouse (YAC128) brain. | 2022 May 11 |
1 |
| 5 |
35143966 | Cerebrospinal fluid mutant huntingtin is a biomarker for huntingtin lowering in the striatum of Huntington disease mice. | 2022 May |
3 |
| 6 |
35262396 | Alterations in the Gut Fungal Community in a Mouse Model of Huntington's Disease. | 2022 Apr 27 |
1 |
| 7 |
35626712 | Identification of the Transcriptional Biomarkers Panel Linked to Pathological Remodelling of the Eye Tissues in Various HD Mouse Models. | 2022 May 18 |
3 |
| 8 |
33310753 | Mutant Huntingtin Is Cleared from the Brain via Active Mechanisms in Huntington Disease. | 2021 Jan 27 |
2 |
| 9 |
33517535 | Developmental malformations in Huntington disease: neuropathologic evidence of focal neuronal migration defects in a subset of adult brains. | 2021 Mar |
1 |
| 10 |
33579860 | Modifiers of Somatic Repeat Instability in Mouse Models of Friedreich Ataxia and the Fragile X-Related Disorders: Implications for the Mechanism of Somatic Expansion in Huntington's Disease. | 2021 |
3 |
| 11 |
33675499 | Small Non-coding RNAs Are Dysregulated in Huntington's Disease Transgenic Mice Independently of the Therapeutic Effects of an Environmental Intervention. | 2021 Jul |
1 |
| 12 |
33710799 | A novel Huntington's disease mouse model to assess the role of neuroinflammation on disease progression and to develop human cell therapies. | 2021 Jul |
2 |
| 13 |
34011527 | Single-Nucleus RNA-Seq Reveals Dysregulation of Striatal Cell Identity Due to Huntington's Disease Mutations. | 2021 Jun 23 |
2 |
| 14 |
34206228 | Cell Reprogramming to Model Huntington's Disease: A Comprehensive Review. | 2021 Jun 22 |
1 |
| 15 |
30194046 | Microbiome profiling reveals gut dysbiosis in a transgenic mouse model of Huntington's disease. | 2020 Feb |
2 |
| 16 |
32448329 | Interleukin-6 deficiency exacerbates Huntington's disease model phenotypes. | 2020 May 24 |
1 |
| 17 |
32702387 | Lentiviral delivery of human erythropoietin attenuates hippocampal atrophy and improves cognition in the R6/2 mouse model of Huntington's disease. | 2020 Oct |
2 |
| 18 |
30626701 | Loss-of-Huntingtin in Medial and Lateral Ganglionic Lineages Differentially Disrupts Regional Interneuron and Projection Neuron Subtypes and Promotes Huntington's Disease-Associated Behavioral, Cellular, and Pathological Hallmarks. | 2019 Mar 6 |
1 |
| 19 |
30881980 | Modulation of Phospho-CREB by Systemically Administered Recombinant BDNF in the Hippocampus of the R6/2 Mouse Model of Huntington's Disease. | 2019 |
2 |
| 20 |
30913220 | Meso scale discovery-based assays for the detection of aggregated huntingtin. | 2019 |
3 |
| 21 |
31040226 | Hdac4 Interactions in Huntington's Disease Viewed Through the Prism of Multiomics. | 2019 Aug 9 |
2 |
| 22 |
31079989 | Focused ultrasound-induced blood brain-barrier opening enhanced vascular permeability for GDNF delivery in Huntington's disease mouse model. | 2019 Sep - Oct |
2 |
| 23 |
31263285 | Allele-selective transcriptional repression of mutant HTT for the treatment of Huntington's disease. | 2019 Jul |
3 |
| 24 |
31465962 | CRISPR-Cas9-Mediated Genome Editing Increases Lifespan and Improves Motor Deficits in a Huntington's Disease Mouse Model. | 2019 Sep 6 |
2 |
| 25 |
31529216 | Cell-Autonomous and Non-cell-Autonomous Pathogenic Mechanisms in Huntington's Disease: Insights from In Vitro and In Vivo Models. | 2019 Oct |
1 |
| 26 |
31695068 | Genetic deletion of S6k1 does not rescue the phenotypic deficits observed in the R6/2 mouse model of Huntington's disease. | 2019 Nov 6 |
1 |
| 27 |
28858902 | Huntington Mice Demonstrate Diminished Pain Response in Inflammatory Pain Model. | 2018 Feb |
3 |
| 28 |
30186318 | Antidepressant Effects of Probucol on Early-Symptomatic YAC128 Transgenic Mice for Huntington's Disease. | 2018 |
1 |
| 29 |
27913616 | Genetic Contributors to Intergenerational CAG Repeat Instability in Huntington's Disease Knock-In Mice. | 2017 Feb |
1 |
| 30 |
27992085 | Muscle atrophy is associated with cervical spinal motoneuron loss in BACHD mouse model for Huntington's disease. | 2017 Mar |
1 |
| 31 |
26642438 | PPAR-δ is repressed in Huntington's disease, is required for normal neuronal function and can be targeted therapeutically. | 2016 Jan |
3 |
| 32 |
26783111 | Increased Olfactory Bulb BDNF Expression Does Not Rescue Deficits in Olfactory Neurogenesis in the Huntington's Disease R6/2 Mouse. | 2016 Mar |
1 |
| 33 |
26859386 | Characterization of Behavioral, Neuropathological, Brain Metabolic and Key Molecular Changes in zQ175 Knock-In Mouse Model of Huntington's Disease. | 2016 |
2 |
| 34 |
27107943 | Atypical ubiquitination by E3 ligase WWP1 inhibits the proteasome-mediated degradation of mutant huntingtin. | 2016 Jul 15 |
3 |
| 35 |
27258586 | A Longitudinal Motor Characterisation of the HdhQ111 Mouse Model of Huntington's Disease. | 2016 May 31 |
1 |
| 36 |
25505248 | Amitriptyline improves motor function via enhanced neurotrophin signaling and mitochondrial functions in the murine N171-82Q Huntington disease model. | 2015 Jan 30 |
3 |
| 37 |
25859666 | Characterization of HTT inclusion size, location, and timing in the zQ175 mouse model of Huntington's disease: an in vivo high-content imaging study. | 2015 |
1 |
| 38 |
25871323 | Dysfunctional Dopaminergic Neurones in Mouse Models of Huntington's Disease: A Role for SK3 Channels. | 2015 |
1 |
| 39 |
26664998 | Thiol-disulfide Oxidoreductases TRX1 and TMX3 Decrease Neuronal Atrophy in a Lentiviral Mouse Model of Huntington's Disease. | 2015 Nov 6 |
4 |
| 40 |
24389360 | Identification of novel alternative splicing events in the huntingtin gene and assessment of the functional consequences using structural protein homology modelling. | 2014 Apr 3 |
2 |
| 41 |
24946181 | AMPK-α1 functions downstream of oxidative stress to mediate neuronal atrophy in Huntington's disease. | 2014 Sep |
2 |
| 42 |
25035419 | Phosphorodiamidate morpholino oligomers suppress mutant huntingtin expression and attenuate neurotoxicity. | 2014 Dec 1 |
2 |
| 43 |
25348412 | Altered Ca(2+) signaling in skeletal muscle fibers of the R6/2 mouse, a model of Huntington's disease. | 2014 Nov |
1 |
| 44 |
22422149 | Significantly differential diffusion of neuropathological aggregates in the brain of transgenic mice carrying N-terminal mutant huntingtin fused with green fluorescent protein. | 2013 Jan |
2 |
| 45 |
22633949 | Dysregulation of synaptic proteins, dendritic spine abnormalities and pathological plasticity of synapses as experience-dependent mediators of cognitive and psychiatric symptoms in Huntington's disease. | 2013 Oct 22 |
1 |
| 46 |
23446639 | Small-molecule TrkB receptor agonists improve motor function and extend survival in a mouse model of Huntington's disease. | 2013 Jun 15 |
1 |
| 47 |
23455440 | Epigenetic regulation of cholinergic receptor M1 (CHRM1) by histone H3K9me3 impairs Ca(2+) signaling in Huntington's disease. | 2013 May |
1 |
| 48 |
23549885 | Targeting sirtuin-1 in Huntington's disease: rationale and current status. | 2013 May |
2 |
| 49 |
24041806 | Oxidative stress causes DNA triplet expansion in Huntington's disease mouse embryonic stem cells. | 2013 Nov |
2 |
| 50 |
21907283 | PPARgamma rescue of the mitochondrial dysfunction in Huntington's disease. | 2012 Jan |
2 |