Simeprevir

KRAS proto-oncogene, GTPase ; Homo sapiens







20 Article(s)
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Pub. Year
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1 34903667 Components of the phosphatidylserine endoplasmic reticulum to plasma membrane transport mechanism as targets for KRAS inhibition in pancreatic cancer. 2021 Dec 21 2
2 30880098 Prevalence of baseline NS3 resistance-associated substitutions (RASs) on treatment with protease inhibitors in patients infected with HCV genotype 1. 2019 Nov 1
3 28228479 Unraveling the structural basis of grazoprevir potency against clinically relevant substitutions in hepatitis C virus NS3/4A protease from genotype 1a. 2017 Apr 14 1
4 28270091 Implications of hepatitis C virus subtype 1a migration patterns for virus genetic sequencing policies in Italy. 2017 Mar 7 2
5 28569206 Virology analysis in HCV genotype 1-infected patients treated with the combination of simeprevir and TMC647055/ritonavir, with and without ribavirin, and JNJ-56914845. 2017 May 31 1
6 28877086 Short article: Retreatment of chronic hepatitis C virus infection after unsuccessful therapy with all-oral direct-acting antiviral regimens: a real-life experience. 2017 Nov 1
7 28011961 Genotypic analysis of HCV 1a by sequencing of the NS3 proteasic region in simeprevir therapy candidates. 2016 Dec 1 4
8 25389307 Global origin and transmission of hepatitis C virus nonstructural protein 3 Q80K polymorphism. 2015 Apr 15 1
9 25529083 How to optimize current therapy in hepatitis C virus genotype 1 patients. Predictors of response to interferon-based therapy with second wave direct acting antivirals. 2015 Jan 1
10 25959702 Diversity of 1,213 hepatitis C virus NS3 protease sequences from a clinical virology laboratory database in Marseille university hospitals, southeastern France. 2015 Nov 1
11 26135875 Development and Validation of Two Screening Assays for the Hepatitis C Virus NS3 Q80K Polymorphism Associated with Reduced Response to Combination Treatment Regimens Containing Simeprevir. 2015 Sep 2
12 26213689 Two Distinct Hepatitis C Virus Genotype 1a Clades Have Different Geographical Distribution and Association With Natural Resistance to NS3 Protease Inhibitors. 2015 Apr 1
13 26232533 Detection of the NS3 Q80K polymorphism by Sanger and deep sequencing in hepatitis C virus genotype 1a strains in the UK. 2015 Nov 1
14 26248125 Resistance to direct-acting antiviral agents: clinical utility and significance. 2015 Sep 1
15 26249823 Predominance of hepatitis C virus Q80K among NS3 baseline-resistance-associated amino acid variants in direct-antiviral-agent-naïve patients with chronic hepatitis: single-centre experience. 2015 Nov 4
16 26392483 In Vitro Activity of Simeprevir against Hepatitis C Virus Genotype 1 Clinical Isolates and Its Correlation with NS3 Sequence and Site-Directed Mutants. 2015 Dec 6
17 25002352 Antiviral treatment of hepatitis C. 2014 Jul 7 1
18 25397486 Appearance of NS3 Q80K mutation in HCV genotype 1a mono- or HIV/HCV co-infected patients in a Berlin laboratory. 2014 1
19 22127068 Molecular modeling study on the resistance mechanism of HCV NS3/4A serine protease mutants R155K, A156V and D168A to TMC435. 2012 Jan 6
20 18678486 Structure-activity relationship study on a novel series of cyclopentane-containing macrocyclic inhibitors of the hepatitis C virus NS3/4A protease leading to the discovery of TMC435350. 2008 Sep 1 1