NVP-BKM120

KRAS proto-oncogene, GTPase ; Homo sapiens







8 Article(s)
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Pub. Year
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1 35251316 Molecular landscape of osimertinib resistance in patients and patient-derived preclinical models. 2022 1
2 34210314 Dual targeting of MEK and PI3K effectively controls the proliferation of human EGFR-TKI resistant non-small cell lung carcinoma cell lines with different genetic backgrounds. 2021 Jul 1 1
3 31506897 A phase Ib study of a PI3Kinase inhibitor BKM120 in combination with panitumumab in patients with KRAS wild-type advanced colorectal cancer. 2020 Aug 1
4 29024814 Anti-tumor effects of NVP-BKM120 alone or in combination with MEK162 in biliary tract cancer. 2017 Dec 28 4
5 26715098 Targeting the PI3K signaling pathway in KRAS mutant colon cancer. 2016 Feb 2
6 27121230 Combined use of PI3K and MEK inhibitors synergistically inhibits lung cancer with EGFR and KRAS mutations. 2016 Jul 3
7 25500057 A phase Ib dose-escalation study of the oral pan-PI3K inhibitor buparlisib (BKM120) in combination with the oral MEK1/2 inhibitor trametinib (GSK1120212) in patients with selected advanced solid tumors. 2015 Feb 15 1
8 22159814 NVP-BKM120, a novel PI3K inhibitor, shows synergism with a STAT3 inhibitor in human gastric cancer cells harboring KRAS mutations. 2012 Apr 2